Abstract
Reserpine, when administered to neonatal rats, is able to induce permanent alterations of various endocrine systems, possibly through damage induced in the developing hypothalamus. The drug, when given as a single injection of 50 µg to newborn female rats, induces a delayed puberty followed by prolonged periods of dioestrous; in treated animals, ovulation occurs only occasionally. Animals treated with reserpine (when studied in adult life) exhibit a decrease in the pituitary content of LH, FSH, and TSH (Carraro et al., 1965; Caviezel et al., 1967); the concentrations of the FSH-Releasing Factor (FSH-RF) and of the TSH-Releasing Factor (TRF) in the hypothalamus are reduced significantly; the T/S ratio is also diminished (Martini et al., 1966; Caviezel et al., 1967).
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Caviezel, F., Gavazzi, G., Colombo, L. (1974). Early Effects of Thyroxine and Reserpine on the Hypothalamic-Pituitary-Thyroid Axis of Young Rats. In: Genazzani, E., Herken, H. (eds) Central Nervous System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65714-6_29
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DOI: https://doi.org/10.1007/978-3-642-65714-6_29
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