Neuronal Activity and Axonal Flow

  • G. W. Kreutzberg
  • P. Schubert


It has been shown that several transport systems exist in the neuron and its processes. In the axon, material is transported at slow and fast rates, which differ by one or even two orders of magnitude. Material is transported in the dendrites at rates approximating axonal fast flow. A selective gate mechanism is postulated for both axonal and dendritic transport, as some organelles are observed either predominantely in the axons and rarely in the dendrites, or rarely in the axons and predominantely in the dendrites.

Substances important for the function of the neuron, e.g. synaptic proteins, neurotransmitters, and enzymes involved in their metabolism etc., are transported in the axons. It seems that the rate and intensity of axonal transport is related to the functional activity of the neurons.

A technique has been developed in our laboratories, combining the intracellular injection of radioactive substances, with electrophysiological recording followed by autoradiodraphy. Data for the intracellular transport of proteins, RNA, and choline derivatives as elucidated by this method are presented.

Key words

Axonal transport dendritic transport orotic acid choline 


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  1. Ansell, B. G., Spanner, S.: Biochem. J. 110, 201–206 (1968).PubMedGoogle Scholar
  2. Barondes, S. H.: Axoplasmic transport. In: Neurosciences research symposium summaries; Schmitt, Melnechuk, Quarton and Adelman (Eds.). The MIT Press, Cambridge, Mass. pp. 191–299 (1969).Google Scholar
  3. Bondy, S. C: Exp. Brain Res. 13, 135–139 (1971).PubMedGoogle Scholar
  4. Borisy, G. G., Taylor, E. W.: J. Cell Biol. 34, 525–533 (1967).PubMedCrossRefGoogle Scholar
  5. Dahlström, A.: Europ. J. Pharmacol. 5, 111–113 (1968).CrossRefGoogle Scholar
  6. Diamond, I., Milfay, D.: J. Neurochem. 19, 1899–1910 (1972).PubMedCrossRefGoogle Scholar
  7. Edström, A.: J. Neurochem. 11, 309–314 (1964).CrossRefGoogle Scholar
  8. Forman, D. S., McEwen, B. S., Grafstein, B.: Brain Res. 28, 119–130 (1971).PubMedCrossRefGoogle Scholar
  9. Geffen, L. B., Livett, B. G.: Physiol. Rev. 51, 98–157 (1971).PubMedGoogle Scholar
  10. Globus, A., Lux, H. D., Schubert, P.: Brain Res. 11, 440–445 (1968).PubMedCrossRefGoogle Scholar
  11. Grafstein, B.: Advanc. Biochem. Psychopharmacol. 1, 11–25 (1969).Google Scholar
  12. Hebb, C. O., Waites, G. M. H.: J. Physiol. 132, 667–671 (1956).PubMedGoogle Scholar
  13. Kasá, P., Morris, D.: J. Neurochem. 19, 1299–1304 (1972).PubMedCrossRefGoogle Scholar
  14. Kreutzberg, G. W.: Proc. nat. Acad. Sci. 62, 722–728 (1969).PubMedCrossRefGoogle Scholar
  15. Lubinska, L., Niemierko, S., Oderfeld, B., Szwarc, L.: Science 135, 368–370 (1962).PubMedCrossRefGoogle Scholar
  16. Lux, H. D., Schubert, P., Kreutzberg, G. W.: Direct matching of morphological and electrophysiological data in cat spinal motoneurons Pg. 189–198. In: Excitatory synaptic mechanism, P. Anderson and J. Jansen (eds.). Oslo: Universitets Forlaget 1970.Google Scholar
  17. Lux, H. D., Schubert, P., Kreutzberg, G. W., Globus, A.: Exp. Brain Res. 10, 197–204 (1970).PubMedCrossRefGoogle Scholar
  18. Miani, N.: J. Neurochem. 10, 859–874 (1963).PubMedCrossRefGoogle Scholar
  19. Miledi, R., Slater, R.: J. Physiol. 207, 507–528 (1970).PubMedGoogle Scholar
  20. Ochs, S.: Acta neuropath. Suppl. 5, 86–96 (1971).PubMedGoogle Scholar
  21. Ochs, S.: Science 176, 252–260 (1972).PubMedCrossRefGoogle Scholar
  22. Schubert, P., Lux, H. D., Kreutzberg, G. W.: Acta neuropath. (Berl.) Suppl. 5, 179–186 (1971).Google Scholar
  23. Schubert, P., Kreutzberg, G. W., Lux, H. D.: Brain Res. 47, 331–343 (1972).PubMedCrossRefGoogle Scholar
  24. Sjöstrand, J.: Brain Res. 13, 617–619 (1969).PubMedCrossRefGoogle Scholar
  25. Weiss, P.: Anat. Rec. 88, 464 (1944).CrossRefGoogle Scholar
  26. Weiss, P., Hiscoe, H. B.: J. Exp. Zool. 107, 315–343 (1948).PubMedCrossRefGoogle Scholar
  27. Weiss, P.: The concept of perpetual neuronal growth and proximo-distal substance convection. In: Regional Neurochemistry, S. S. Kety and J. J. Elkes (Eds.) pg. 220. New York: Pergamon Press (1961).Google Scholar
  28. Weiss, P.: Proc. nat. Acad. Sci. 57, 1239–1245 (1967).PubMedCrossRefGoogle Scholar
  29. Yamamura, H. I., Snyder, S. H.: Science 178, 626–628 (1972).PubMedCrossRefGoogle Scholar
  30. Zatz, M., Barondes, S. H.: J. Neurochem. 18, 1125–1133 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • G. W. Kreutzberg
    • 1
  • P. Schubert
    • 1
  1. 1.Max-Planck-Institut für PsychiatrieMünchenWestern Germany

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