Abstract
The mammalian brain contains about 3 µmoles per gram of simple adenosine derivatives, mainly the triphosphate (ATP). On excitation, cerebral ATP can undergo reaction at 0.1–1 µmol/g.s. at its phosphate group. The regulatory roles of the major reactions and their products are relatively well-known; they control the cation concentrations and membrane potentials of the individual cellular components of the brain, and also certain synthetic processes.
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References
Burnstock, G., Campbell, G., Satchell, D., Smythe, A.: Brit. J. Pharmacol. 40, 668 (1970).
Douglas, W. W., Poisner, A. M.: J. Physiol. 183, 249 (1966).
Geffen, L. B., Livett, B. G.: Physiol. Rev. 51, 98 (1971).
Greengard, P., Costa, E,: Role of Cyclic AMP in Cell Function. New York: Raven. (1970).
Heller, I., McIlwain, H.: Brain Research 53, 105 (1973).
Holton, F A., Holton, P.: J. Physiol. 126, 124 (1954).
Kakiuchi, S., Rall, T. W.: Mol. Pharmacol. 4, 367, 379 (1968).
Kakiuchi, S., Rall, T. W., McIlwain, H.: J. Neurochem. 16, 485 (1969).
Katz, R. I., Chase, T. N.: Advances in Pharmacol. Chemother. 8, 1 (1970).
Kawai, N.: Neuropharmacology. 9, 395 (1970).
Langan, T. A.: See Greengard and Costa (1970) p. 307 (1970).
McIlwain, H.: In Effects of Drugs on Cellular Control Mechanisms. Edit. Rabin and Freedman. London: Macmillan. (1971).
McIlwain, H.: Biochemical Society Symposia 36, 69 (1972).
McIlwain, H., Bachelard, H. S.: Biochemistry and the Central Nervous System. 4th Ed. London: Churchill Livingstone. (1971).
McIlwain, H., Snyder, S. H.: J. Neurochem. 17, 521 (1970).
Pull, I., McIlwain, H.: Biochem. J. 126, 965 (1972).
Pull, I., McIlwain, H.: Biochem. J. 30, 975 (1973).
Reddington, M., Rodnight, R.: Biochem. J. 126, 14 P (1972).
Robinson, G. A., Butcher, R. W., Sutherland, E. W.: Cyclic AMP. New York: Academic Press (1971).
Rodnight, R., Weller, M.: In Effects of Drugs on Cellular Control Mechanisms. Edit. Rabin and Freedman. London: Macmillan. (1971).
Santos, J. N., Hempstead, K. W., Kopp, L., Miech, R. P.: J. Neurochem 15, 367 (1968).
Sattin, A.: J. Neurochem. 18, 1087 (1971).
Sattin, A., Rall, T. W.: Mol. Pharmacol. 6, 13 (1970).
Shimizu, H., Creveling, C. R., Daly, J.: Proc. Nat. Acad. Sci. US. 65, 1033 (1970).
Thomas, J.: Biochem. J. 66, 655 (1957).
Weller, M., Rodnight, R.: Biochem. J. 124, 393 (1971).
Zubray, G., Schwartz, D., Beckwith, J.: Proc. Nat. Acad. Sci. U. S. 66, 104 (1970).
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© 1974 Springer-Verlag Berlin · Heidelberg
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McIlwain, H. (1974). Adenosine in Neurohumoral and Regulatory Roles in the Brain. In: Genazzani, E., Herken, H. (eds) Central Nervous System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65714-6_1
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DOI: https://doi.org/10.1007/978-3-642-65714-6_1
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