Renal Anomalies

  • D. Innes Williams
Part of the Handbuch der Urologie / Encyclopedia of Urology book series (HDBUROL, volume 15 / 1)

Abstract

The renal parenchymal anomalies, hypoplasia, dysplasia and cystic disease, present in a bewildering variety of forms either alone or as part of multiple congenital anomaly syndromes. Clearly these changes can occur in response to a number of factors, either genetic or environmental. Many of the conditions are well recognised to be inherited, but it has been shown experimentally that ureteric obstruction can produce cystic dysplasia (Bernstein, 1968). Cystic disease has been induced in new born rabbits by diphenylamine derivatives (Crocker et al., 1972), by nordihydroguaiaretic acid, an antioxidant used in edible oils (Goodman et al., 1970) and by Prednisolone (Percy et al., 1967). Multicystic kidney has been found in association with congenital cytomegalovirus infection (Plotkin and Pasquariello, 1969). As might be expected with so many possible influences involved, the pathological distinction between one form of cystic disease and another, or between cystic disease and dysplasia, is often blurred. The classical contributions of Osathanondh and Potter (1964) are the most important recent attempt to establish a reliable pathological classification and are indispensible to a serious study of the pathogenesis, but the clinico-pathological disease patterns are more important to the urologist and it is with these that this chapter is concerned.

Keywords

Adenoma Proteinuria Prednisolone Pyramid Hydrocephalus 

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© Springer-Verlag Berlin Heidelberg 1974

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  • D. Innes Williams

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