Abstract
Once an animal has been infected in utero or neonatally with LCM virus, that virus can persist in most tissues throughout the animal’s life (11,29,30). This finding along with the inability to find free circulating antibody to LCM virus in such mice led Burnet to postulate in the late 1940’s that mice infected with LCM virus were immunologically tolerant to this agent (3). Doubts about the validity of this concept were first raised in the late 1960’s in our laboratory (16). While observing immunopathological and virological events in chronically infected mice, we found host immunoglobulin G (IgG), complement (C3, 3rd complement component) and LCM viral antigen(s) deposited in the renal glomeruli in a granular pattern (16). This picture of antigen, IgG and C3 deposits had been seen many times before in different diseases and is pathognomonic of immune complex deposits (5,6). This suggested that these mice, in spite of carrying persistent titers of LCM virus, were also mounting an anti-viral antibody response, the antibody complexing with virus in the circulation to form virus-anti-viral antibody (V-Ab) complexes which subsequently became trapped in the renal glomeruli. Later experimental work indeed showed both the presence of circulating V-Ab complexes (17,18) and of specific antibody to LCM virus (16,17,18). Later observations indicated that in some strains, i.e., NZB,(NZB x W)F1, about 15 to 20% of infected mice made detectable free circulating antibody by 6 to 9 months of age.
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Literature
Banks, K.L., J.B. Henson, and T.C. McGuire: Immunologically mediated glomerulitis of horses. I. Pathogenesis in persistent infection by equine infectious anemia virus. Lab. Invest. 26: 701–707 (1972).
Blomgren, H., and E. Svedmyr: Evidence for thymic dependence of PHA-reactive cells in spleen and lymph nodes and independence in bone marrow. J. Immunol. 106: 835–841 (1971).
Burnet, F.M., and F. Fenner: The Production of Antibodies. Second ed. Melbourne: Macmillan Co. 1949.
Chiller, J.M., G.S. Habicht, and W.O. Weigle: Cellular sites of immunologic unresponsiveness. Proc. nat. Acad. Sci. (Wash.) 65: 551–556 (1970).
Dixon, F.J.: The role of antigen-antibody complexes in disease. Harvey Lect. Series 58: 21–52 (1962/63).
Dixon, F.J.: The pathogenesis of glomerulonephritis. Amer. J. Med. 44: 493–498 (1968).
Hanaoka, M., S. Suzuki, and J. Hotchin: Thymus-dependent lymphocytes: destruction by lymphocytic choriomeningitis virus. Science 163: 1216–1219 (1969).
Henson, J.B., J.R. Gorham, G.A. Padgett, and W.C. Davis: Pathogenesis of the glomerular lesions in Aleutian disease of mink. Immunofluorescent studies. Arch. Path. 87: 21–28 (1969).
Hirsch, M.S., A.C. Allison, and J.J. Harvey: Immune complexes in mice infected neonatally with Moloney leukaemogenic and murine sarcoma viruses. Nature (Lond.) 223: 739–740 (1969).
Hoffsten, P., and F.J. Dixon: Personal communications.
Hotchin, J.: The biology of lymphocytic choriomeningitis infection: virus-induced immune disease. Cold Spr. Harbor Symp. Quant. Biol. 27: 479–499 (1962).
Lundstedt, C.: Interaction between antigenically different cells. Virus-induced cytotoxicity by immune lymphoid cells in vitro. Acta path. microbiol. scand. 75: 139–152 (1969).
McGuire, T.C., T.B. Crawford, and J.B. Henson: Manuscript in preparation.
Notkins, A.L., S. Mahar, C. Scheele, and J. Goffman: Infectious virus-antibody complex in the blood of chronically infected mice. J. exp. Med. 124: 81–97 (1966).
Oldstone, M.B.A., T. Aoki, and F.J. Dixon: The antibody response of mice to murine leukemia virus in spontaneous infection: absence of classical immunologic tolerance. Proc. nat. Acad. Sci. (Wash.) 69: 134–138 (1972).
Oldstone, M.B.A., and F.J. Dixon: Lymphocytic choriomeningitis: production of antibody by “tolerant” infected mice. Science 158: 1193–1195 (1967).
Oldstone, M.B.A., and F.J. Dixon: Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice. J. exp. Med. 129: 483–505 (1969).
Oldstone, M.B.A., and F.J. Dixon: Persistent lymphocytic choriomeningitis viral infection. III. Virus-anti-viral antibody complexes and associated chronic disease following transplacental infection. J. Immunol. 105: 829–837 (1970).
Oldstone, M.B.A., and F.J. Dixon: Tissue injury in lymphocytic choriomeningitis viral infection: virus-induced immunologically specific release of a cytotoxic factor from immune lymphoid cells. Virology 42: 805–813 (1970).
Oldstone, M.B.A., and F.J. Dixon: The immune response in lymphocytic choriomeningitis viral infection. In: Immunopathology. 6th Internat. Symp., 1970. Ed.: P.A. Miescher. Basel, Stuttgart: Schwabe und Co. 1971.
Oldstone, M.B.A., and F.J. Dixon: Lactic dehydrogenase virusinduced immune complex type of glomerulonephritis. J. Immunol. 106: 1260–1263 (1971).
Oldstone, M.B.A., K. Habel, and F.J. Dixon: The pathogenesis of cellular injury associated with persistent LCM viral infection. Fed. Proc. 28: 429 (only) (1969).
Parrott, D.M.V., M.A.B. de Sousa, and J. East: Thymus-dependent areas in the lymphoid organs of neonatally thymectomized mice. J. exp. Med. 123: 191–204 (1966).
Porter, D.O., and A.E. Larsen: Aleutian disease of mink: infectious virus-antibody complexes in the serum. Proc. Soc. exp. Biol. (N.Y.) 126: 680–682 (1967).
Porter, D.O., A.E. Larsen, and H.G. Porter: The pathogenesis of Aleutian disease of mink. I. In vivo viral replication and the host antibody response to viral antigen. J. exp. Med. 130: 575–593 (1969).
Porter, D.O., and H.G. Porter: Deposition of immune complexes in the kidneys of mice infected with lactic dehydrogenase virus. J. Immunol. 106: 1264–1266 (1971).
Raff, M.C.: Theta isoantigen as a marker of thymus-derived lymphocytes in mice. Nature (Lond.) 224: 378–379 (1969).
Raff, M.C., and H.H. Wortis: Thymus dependence of a-bearing cells in the peripheral lymphoid tissues of mice. Immunology 18: 931–942 (1970).
Traub, E.: A filterable virus recovered from white mice. Science 81: 298–299 (1935).
Traub, E.: Persistence of lymphocytic choriomeningitis virus in immune animals and its relation to immunity. J. exp. Med. 63: 847–861 (1936).
Tubergen, D.G., and M.B.A. Oldstone: Release of macrophage migration inhibitory factor by virus-infected spleen cells. J. Immunol. 107: 1483–1485 (1971).
Volkert, M.: Studies on immunologic tolerance to LCM virus. In: Perspectives in Virology. IV. Ed.: M. Pollard. New York: Hoeber Medical Division, Harper and Row, Inc. 1965.
Volkert, M., and J. Hannover Larsen: Immunological tolerance to viruses. Progr. med. Virol. 7: 160–207 (1965).
Wahren, B., and D. Metcalf: Cytotoxicity in vitro of preleukaemic lymphoid cells on syngeneic monolayers of embryo or thymus cells. Clin. exp. Immunol. 7: 373–386 (1970).
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Oldstone, M.B.A. (1973). Thymus-Dependent (T) Cell Competence in Chronic LCM Virus Infection. In: Lehmann-Grube, F. (eds) Lymphocytic Choriomeningitis Virus and Other Arenaviruses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65681-1_17
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DOI: https://doi.org/10.1007/978-3-642-65681-1_17
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