Summary
It was observed that doses of x-rays which were sublethal to normal mice could induce fatal diseases in mice infected with LCM virus. The enhanced sensitivity to x-irradiation was seen in persistent, tolerant virus carriers and also in acutely infected mice. The findings indicated that both types of LCM virus infection were associated with hemopoietic disorders. By means of the spleen colony methods it was shown that the function of hemopoietic stem cells is strongly inhibited during acute LCM virus infection. In the virus carriers no inhibition of the hemopoietic stem cells was observed, but the numbers of these cells were significantly decreased. It is suggested that the viral influence upon the stem cells may play an important role for the induction of immunological tolerance by the LCM virus.
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Literature
Bro-Jørgensen, K., and M. Volkert: Haemopoietic defects in mice in-fected with lymphocytic choriomeningitis virus. 1. The enhanced X-ray sensitivity of virus infected mice. Acta path. microbiol. scand. B 80: 845–852 (1972).
Curry, J.L., and J.J. Trentin: Hemopoietic spleen colony studies. I. Growth and differentiation. Develop. Biol. 15: 395–413 (1967).
Hannover Larsen, J.: The effect of immunosuppressive therapy on the murine lymphocytic choriomeningitis virus infection. Acta path. microbiol. scand. 77: 433–446 (1969).
Hotchin, J.E., and M. Cinits: Lymphocytic choriomeningitis infection of mice as a model for the study of latent virus infection. Canad. J. Microbiol. 4: 149–163 (1958).
Hotchin, J., and H. Weigand: The effects of pretreatment with x-rays on the pathogenesis of lymphocytic choriomeningitis in mice. I. Host survival, virus multiplication and leukocytosis. J. Immunol. 87: 675–681 (1961).
Metcalf, D., and M.A.S. Moore: Haemopoietic Cells. Frontiers of Biology 24. Amsterdam, London: North-Holland Publishing Co. 1971.
Rowe, W.P.: Protective effect of pre-irradiation on lymphocytic choriomeningitis infection in mice. Proc. Soc. exp. Biol. (N.Y.) 92: 194–198 (1956).
Till, J.E., and E.A. McCulloch: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Rad. Res. 14: 2l3–222 (1961).
Till, J.E., and E.A. McCulloch: Repair processes in irradiated mouse hemapoietic tissue. Ann. N.Y. Acad. Sci. 114: 115–125 (1964).
Trentin, J., N. Wolf, V. Cheng, W. Fahlberg, D. Weiss, and R. Bonhag: Antibody production by mice repopulated with limited numbers of clones of lymphoid cell precursors. J. Immunol. 98: 1326–l337 (1967).
Volkert, M.: Studies on immunological tolerance to LCM virus. A preliminary report on adoptive immunization of virus carrier mice. Acta path. microbiol. scand. 56: 305–310 (1962).
Wu, A.M., J.E. Till, L. Siminovitch, and E.A. McCulloch: Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system. J. exp. Med. 127: 455–464 (1968).
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Bro-Jørgensen, K., Volkert, M. (1973). LCM Virus-Induced Hemopoietic Disorder in Mice and its Role in the Induction of Tolerance. In: Lehmann-Grube, F. (eds) Lymphocytic Choriomeningitis Virus and Other Arenaviruses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65681-1_12
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DOI: https://doi.org/10.1007/978-3-642-65681-1_12
Publisher Name: Springer, Berlin, Heidelberg
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