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Clinical Applications of Cell Cycle Kinetics

  • Chapter
Antineoplastic and Immunosuppressive Agents Part I

Abstract

Clinicians experienced in treating cancer have long been aware of the great variability in growth rates among different types of cancer and even within the same type, but until recently estimates of growth rates were largely limited to measurements of volume doubling times of solid tumors visible externally or roentgenographically (Collins et al., 1956; Collins, 1962; Garland et al., 1963; Spratt and Spratt, 1964; Charbit et al., 1971). These estimates were necessarily rough and gave little insight into the many factors which can influence the doubling time, such as the tumor cells’ intermitotic time and its variability, the relative proportions of actively proliferating and resting tumor cells, changes in the tumor’s proliferative behavior during different stages of growth, rate of cell loss, influence of vascular supply, contribution of stromal tissues, hemorrhage or necrosis to the tumor mass, and perturbations caused by therapy. Information about the comparative proliferative rates of normal tissues was also largely lacking.

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Authors
  1. Bayard Clarkson
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Istitutes of Health, Bethesda, Maryland, 20014, USA

    David G. Johns M. D.

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Clarkson, B. (1974). Clinical Applications of Cell Cycle Kinetics. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents Part I. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65678-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-65678-1_8

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