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Rational Design of Pyrimidine Nucleoside Analogs

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Antineoplastic and Immunosuppressive Agents Part I

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Abstract

The uncontrolled growth of cells is characteristic of a group of diseases known as cancer. The major difficulty in coping with this problem is that there is, as yet, little information of particular significance on the biochemical differences between normal and malignant tissues. Out of necessity, the chemotherapeutic approach to oncology has been rather empirical with the major successes being noted with drugs which are generally more toxic to rapidly proliferating cells. Most of these cytotoxic anticancer agents act primarily as inhibitors of nucleic acid synthesis at various sites and by different mechanisms.

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Authors
  1. Leroy B. Townsend
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  2. C. C. Cheng
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Istitutes of Health, Bethesda, Maryland, 20014, USA

    David G. Johns M. D.

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Townsend, L.B., Cheng, C.C. (1974). Rational Design of Pyrimidine Nucleoside Analogs. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents Part I. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65678-1_6

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