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Clinical Utility of Immunosuppressive Agents

  • Chapter
Antineoplastic and Immunosuppressive Agents Part I

Abstract

Immunosuppressive drugs have two principal applications in clinical medicine. They are used in organ transplantation and autoimmune disease. The chemical suppression of the immune response has played an important part in human organ transplantation. Except where identical twins are involved, it is allogeneic grafts that are transplanted. Even with good tissue matching, there is some degree of histocompatibility difference between donor and recipient. In general, the less the histocompatibility difference the longer will be the survival of the grafted organ (van Rood, 1969; Festenstein et al., 1971; Sachs et al., 1971). Survival is further improved by the use of immunosuppressive drugs to abolish or impair the allograft rejection reaction of the recipient (Murray et al., 1963). The rationale for the use of drugs in a transplant situation is clear, and based on sound immunological considerations. In the case of autoimmune disease, however, the argument for the use of immunosuppressive drugs is less cogent. Many diseases are believed to be autoimmune in nature, that is, they are presumed to represent instances of humoral and cell-mediated immune reactivity within the body against antigenic determinants carried by normal tissue. Such an aberrant immune response against self is considered to be both initially responsible for the pathogenesis of the disease and for persisting tissue destruction during the later course of it.

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Authors
  1. Jules E. Harris
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  2. Ramesh C. Bagai
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Istitutes of Health, Bethesda, Maryland, 20014, USA

    David G. Johns M. D.

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© 1974 Springer-Verlag Berlin · Heidelberg

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Harris, J.E., Bagai, R.C. (1974). Clinical Utility of Immunosuppressive Agents. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents Part I. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65678-1_29

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  • DOI: https://doi.org/10.1007/978-3-642-65678-1_29

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