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Radiation Research: Survival Kinetics

  • L. J. Tolmach
  • L. E. Hopwood
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 38 / 1)

Abstract

The lethal action of ionizing radiations on mammalian cells has been observed for almost as long as the existence of these radiations has been known, but even today, with a large body of experimental observations at our disposal, understanding of the mechanisms by which the initial deposition of energy and breakage of chemical bonds lead to cell death is far from complete. Nevertheless, significant progress has been made in recent years, largely through the application of kinetic analysis. This discussion will be restricted mainly to kinetic aspects of cell killing by x- and γ-rays; only cursory consideration will be given to the molecular bases of the phenomena and the cellular organelles involved. It will be apparent that many of the concepts and experimental approaches mentioned apply also to the lethal action of cytotoxic drugs.

Keywords

Linear Energy Transfer Relative Biological Effectiveness Bone Marrow Stem Cell Irradiate Cell Chinese Hamster Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • L. J. Tolmach
  • L. E. Hopwood

There are no affiliations available

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