Radiation Research: Survival Kinetics
The lethal action of ionizing radiations on mammalian cells has been observed for almost as long as the existence of these radiations has been known, but even today, with a large body of experimental observations at our disposal, understanding of the mechanisms by which the initial deposition of energy and breakage of chemical bonds lead to cell death is far from complete. Nevertheless, significant progress has been made in recent years, largely through the application of kinetic analysis. This discussion will be restricted mainly to kinetic aspects of cell killing by x- and γ-rays; only cursory consideration will be given to the molecular bases of the phenomena and the cellular organelles involved. It will be apparent that many of the concepts and experimental approaches mentioned apply also to the lethal action of cytotoxic drugs.
KeywordsLinear Energy Transfer Relative Biological Effectiveness Bone Marrow Stem Cell Irradiate Cell Chinese Hamster Cell
Unable to display preview. Download preview PDF.
- Bond, V.R., Fliedner, T.M., Archambeau, J.O.: Mammalian radiation lethality. New York and London: Academic 1965.Google Scholar
- Bond, V.P., Suit, H.D., Marcial, V. (Eds.): Time and dose relationships in radiation biology as applied to radiotherapy. Upton, N. Y.: Brookhaven National Laboratory 1970.Google Scholar
- Elkind, M.M., Whitmore, G.F.: The radiobiology of cultured mammalian cells. New York: Gordon and Breach 1967.Google Scholar
- Hahn, G.M.: Radiobiology of mammalian cells in the plateau phase of growth. In: Time and dose relationships in radiation biology as applied to radiotherapy, pp. 117–125. Upton, N. Y.: Brookhaven National Laboratory 1970.Google Scholar
- Hopwood, L.E.: Ph. D. Thesis, Washington University, St. Louis, Mo. 1971.Google Scholar
- Lea, D.E.: Actions of radiations on living cells, 2nd ed. Cambridge: University Press 1955.Google Scholar
- Levis, A.G.: Effetti dei raggi x sulla mitosi di cellule di mammiferi coltivate in vitro. Caryologia 15, 59–87 (1962).Google Scholar
- Okada, S.: Radiation biochemistry, Vol. 1. New York: Academic 1970.Google Scholar
- Skipper, H.E.: The cell cycle and chemotherapy of cancer. In: Baserga, R. (Ed.): The cell cycle and cancer, pp. 358–387. New York: Dekker 1971.Google Scholar
- Withers, H.R.: Biological basis for high-LET radiotherapy. Radiol. 108, 131–137 (1973).Google Scholar