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Metabolism of Cancer Chemotherapeutic Agents via Pathways Utilized by Endogenous Substrates

  • Chapter
Antineoplastic and Immunosuppressive Agents Part I

Abstract

Cancer chemotherapeutic agents, like other classes of xenobiotics, undergo a variety of metabolic transformations, both anabolic and catabolic in type. The former group of reactions includes such transformations as conversion of purine and pyrimidine analogs, to their pharmacologically active nucleotide forms and incorporation of the latter into nucleic acids. Because of their immediate relevance to the antitumor activity of these agents, and also to mechanisms of acquired resistance to continued therapy, such anabolic conversions have received great attention from investigators in the field of cancer chemotherapy. The catabolic reactions which these drugs undergo, on the other hand, usually result in a partial or complete loss of antitumor activity; the practical impetus toward the study of the latter group of reactions has been the possibility of developing specific inhibitors of such catabolic inactivation, thus increasing the potency and duration of action of the parent form of the drug.

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Authors
  1. David G. Johns
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Istitutes of Health, Bethesda, Maryland, 20014, USA

    David G. Johns M. D.

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© 1974 Springer-Verlag Berlin · Heidelberg

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Johns, D.G. (1974). Metabolism of Cancer Chemotherapeutic Agents via Pathways Utilized by Endogenous Substrates. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents Part I. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65678-1_14

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  • DOI: https://doi.org/10.1007/978-3-642-65678-1_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65680-4

  • Online ISBN: 978-3-642-65678-1

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