“Spherocytes” is an historical term. The cells it describes are actually not spheres. They include a variety of cells which are etiologically and morphologically dissimilar. They have only one thing in common: an increase in their thickness. At present, we can distinguish: I. macro-spherocytes produced by osmotic sweIIing of normal erythrocytes; 2. echino-spherocytes (the extreme form of the disco-echinocyte transformation) and stomato-spherocytes (the extreme form of the disco-stomatocyte transformation): in these two types of spherocytes the cell volume is normal; 3. micro-spherocytes resulting from fragmentation; 4. the spherocytes seen in hereditary spherocytosis.
KeywordsCell Volume Cell Permeability Cell Physiology Central Depression Extreme Form
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