The Effect of Adrenergic Substances on the Ureter Dynamics
Our knowledge of pharmacological effects on ureteral activity is still at an early stage of development. One exact method for examining the effect of various drugs on the ureter activity is the registration of electric potential changes (p.c.) in the syncytial ureter muscles. Several authors (Baker and Huffer, 1953; Hanley, 1953; Weinberg and Maletta, 1961; Shiratori et al., 1961) report different results. In our opinion the varying and even contradictory records of p.c. are due to different techniques of p.c. take-off and to the neglect of factors exerting a direct effect on ureteral dynamics, such as changes of diuresis, the temperature of tissue, disturbed urinary transport resulting from the obstruction constituted by the electrodes and the state of the animal’s circulation during the experiment. It has already been mentioned in our earlier papers (Malatinsky, 1966; 1967) that the sympathomimetics (epinephrine, norepinephrine, ephedrine) may affect ureteral activity. These dmgs have a positive chronotropic effect and raise the frequency of the p.c. in the ureter muscles. The effect with a duration of only a few minutes is constant and reproducible at any time. Boyarsky et al. (1966) demonstrated the presence of catecholamines in the wall of the ureter. This suggests that the ureteral muscles have a sympathetic innervation.
KeywordsCatheter Platinum Norepinephrine Peri Epinephrine
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