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Urodynamics pp 102-106 | Cite as

The Effect of Adrenergic Substances on the Ureter Dynamics

  • E. Malatinsky

Abstract

Our knowledge of pharmacological effects on ureteral activity is still at an early stage of development. One exact method for examining the effect of various drugs on the ureter activity is the registration of electric potential changes (p.c.) in the syncytial ureter muscles. Several authors (Baker and Huffer, 1953; Hanley, 1953; Weinberg and Maletta, 1961; Shiratori et al., 1961) report different results. In our opinion the varying and even contradictory records of p.c. are due to different techniques of p.c. take-off and to the neglect of factors exerting a direct effect on ureteral dynamics, such as changes of diuresis, the temperature of tissue, disturbed urinary transport resulting from the obstruction constituted by the electrodes and the state of the animal’s circulation during the experiment. It has already been mentioned in our earlier papers (Malatinsky, 1966; 1967) that the sympathomimetics (epinephrine, norepinephrine, ephedrine) may affect ureteral activity. These dmgs have a positive chronotropic effect and raise the frequency of the p.c. in the ureter muscles. The effect with a duration of only a few minutes is constant and reproducible at any time. Boyarsky et al. (1966) demonstrated the presence of catecholamines in the wall of the ureter. This suggests that the ureteral muscles have a sympathetic innervation.

Keywords

Sympathetic Innervation Peristaltic Wave Positive Chronotropic Effect Drip Rate Ureteral Peristalsis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baker, R., Huffer, J.: Ureteral electromyography. J. Urol. (Baltimore) 70, 874–884 (1953).Google Scholar
  2. Boyarsky, S., Kirschner, N., Labay, P.: Catecholamine content of the normal ureter pelvis. Invest. Urol. 4, 97–102 (1966).PubMedGoogle Scholar
  3. Hanley, H. G.: The electroureterogram. Brit. J. Urol. 25, 358–365 (1953).PubMedCrossRefGoogle Scholar
  4. Lutzeyer, W., Melchior, H.: Uro-Rheographie. Eine neue Methode der Harnflußmessung im Harnleiter mit Wärmeleitelementen. Urologe 8, 208–214 (1969).PubMedGoogle Scholar
  5. Malatinsky, E.: Význam elektroureterografie v expérimente a v klinickej praxi. Rozhl. Chir. 45, 661–666 (1966).PubMedGoogle Scholar
  6. Malatinsky, E.: Farmakodynamický ûčinok na močovod in situ sledovaný EUG metodou. Rozhl. Chir. 46, 796–803 (1967).PubMedGoogle Scholar
  7. Malatinsky, E.: Sledovanie fyziologickej a arteficiálne zmenenej činnosti močovodov pomocou elektroureterografie. Folia fac. med. Univ. Comenianae Bratislava 7, 191–215 (1969).Google Scholar
  8. Melchior, H., Terhorst, B.: Die Wirkung sympathicotroper Substanzen auf die Ureterdynamik. Urologe 8, 348–352 (1969).PubMedGoogle Scholar
  9. Shiratory, T., Katayose, K., Suetake, Y., Kawamata, S., Kinoshita, H., Takakura, K., Enokido, K., Shiga, R., Nomura, T., Usuba, G., Chiba, K.: Electromyographic Studies on Urinary Tract. I. Fundamental Studies on EMG of Animal and Human Ureters. Tohoku J. exp. Med. 69, 103–117 (1961).CrossRefGoogle Scholar
  10. Sleator, W., Jr., Butcher, H. R., Jr.: Action potentials and pressure changes in ureteral peristaltic waves. Amer. J. Physiol. 180, 261–276 (1955).PubMedGoogle Scholar
  11. Weinberg, S. R., Maletta, T. J.: Measurement of peristalsis of the ureter and its relation to drugs. J. Amer. med. Ass. 175, 15–18 (1961).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1973

Authors and Affiliations

  • E. Malatinsky
    • 1
  1. 1.Department of UrologyUniversity of BratislavaCzechoslovakia

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