Angiotensin pp 500-510 | Cite as

Effects of Angiotensin II on the Permeability of the Vascular Wall

  • A. Lazzarini Robertson
  • P. A. Khairallah
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 37)


Endothelial cells have long been considered selective functional barriers for the transport of blood components across the wall of large blood vessels with a “continuous” endothelial lining because of their intimate contact with circulating blood. Two major routes have been described for blood macromolecules escaping from the vascular lumen: one by intracellular incorporation and transport across the endothelial cell cytoplasm, the other through interendothelial spaces or “tight” junctions. The latter is considered to be morphologically, if not functionally, equivalent to the “small pore” system (less than 90 Å in diameter) found in peripheral capillaries (Florey and Sheppard, 1970).


Evans Blue Vasoactive Agent Medial Smooth Muscle Cell Arterial Endothelium Endothelial Basement Membrane 
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© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • A. Lazzarini Robertson
  • P. A. Khairallah

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