Advertisement

Angiotensin pp 500-510 | Cite as

Effects of Angiotensin II on the Permeability of the Vascular Wall

  • A. Lazzarini Robertson
  • P. A. Khairallah
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 37)

Abstract

Endothelial cells have long been considered selective functional barriers for the transport of blood components across the wall of large blood vessels with a “continuous” endothelial lining because of their intimate contact with circulating blood. Two major routes have been described for blood macromolecules escaping from the vascular lumen: one by intracellular incorporation and transport across the endothelial cell cytoplasm, the other through interendothelial spaces or “tight” junctions. The latter is considered to be morphologically, if not functionally, equivalent to the “small pore” system (less than 90 Å in diameter) found in peripheral capillaries (Florey and Sheppard, 1970).

Keywords

Evans Blue Vasoactive Agent Medial Smooth Muscle Cell Arterial Endothelium Endothelial Basement Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bisset, G. W., Lewis, G. P.: A spectrum of pharmacological activity in some biologically active peptides. Brit. J. Pharmacol. 19, 168 (1962).PubMedGoogle Scholar
  2. Casley-Smith, J. R.: The identification of chylomicra and lipoproteins in tissue sections and their passage into jejunal lacteais. J. Cell Biol. 15, 259 (1962).PubMedCrossRefGoogle Scholar
  3. Constantinides, P., Robinson, M.: Ultrastructural injury of arterial endothelium. I. Effects of pH, osmolarity, anoxia, and temperature. II. Effects of vasoactive amines. Arch. Path. 88, 99 (1969).PubMedGoogle Scholar
  4. Florey, H. W.: The transport of materials across the capillary wall. Quart. J. exp. Physiol. 49, 117 (1964).Google Scholar
  5. Florey, L., Sheppard, B. L.: The permeability of arterial endothelium to horseradish peroxidase. Proc. roy. Soc. 174, 435 (1970).CrossRefGoogle Scholar
  6. FRENCH, J. E.: The behavior of chylomicra in the circulation; observations with the electron microscope. In: Proc. VIth Intern. Conf. Biochemical Problems Lipids. Amsterdam: Elsevier 1963.Google Scholar
  7. French, J. E.: Atherosclerosis in relation to the structure and function of arterial intima, with special reference to the endothelium. In: International Review of Experimental Pathology, Vol. 5. New York: Academic Press 1966.Google Scholar
  8. Karnovsky, J.: The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. J. Cell Biol. 35, 213 (1967).PubMedCrossRefGoogle Scholar
  9. Khairallah, P. A., Robertson, A. L., Davila, D.: Effects of angiotensin II on DNA, RNA and protein synthesis. In: Hypertension — 1972, p. 212 (Genest, J., Koiw, E., Eds.). Berlin-Heidelberg-New York: Springer 1972.Google Scholar
  10. Kincaid-Smith, P., Hobbs, J. B., Friedman, A., Mathews, D. C.: Structural and ultra-structural alterations in mesenteric and renal arterioles following infusion of vaso-active agents. In: Hypertension — 1972, p. 97 (Genest, J., Koiw, E., Eds.). Berlin-Heidelberg-New York: Springer 1972.Google Scholar
  11. Majno, G., Shea, S. M., Leventhal, M.: Endothelial contraction induced by histamine-type mediators. An electron microscopic study. J. Cell Biol. 42, 647 (1969).PubMedCrossRefGoogle Scholar
  12. MAJNO, G.: Endothelial contraction, collagenase digestion of the basement membrane. In: Vascular Factors and Thrombosis. Stuttgart: F. K. Schattauer 1970.Google Scholar
  13. Mustard, J. F., Jorgensen, L., Packham, M. A.: Formed elements as a source of vascular injury. In: Vascular Factors and Thrombosis (Brinkhous, K. M., Ed.). Stuttgart: F. K. Schattauer 1970.Google Scholar
  14. Packham, M. A., Rowsell, H. C., Jorgensen, L., Mustard, J. G.: Localized protein accumulation in the wall of the aorta. Exp. molec. Path. 7, 214 (1967).PubMedCrossRefGoogle Scholar
  15. Robertson, A. L., Khairallah, P. A.: Angiotensin II: Rapid localization in nuclei of smooth and cardiac muscle. Science 172, 1138 (1971).PubMedCrossRefGoogle Scholar
  16. ROBERTSON, A. L., KHAIRALLAH, P. A., KYNCL, J.: Role of endothelial contraction and platelets in atherogenesis. Circulation 6566 (abstract), II—252 (1972).Google Scholar
  17. Robertson, A. L., Khairallah, P. A.: Effects of angiotensin II and some analogs on vascular permeability in the rabbit. Circ. Res. 31, 923 (1972).PubMedGoogle Scholar
  18. Robertson, A. L., Khairallah, P. A.: Arterial endothelial permeability and vascular disease. The “trap door” effect. Exp. molec. Path. 18, 241 (1973).PubMedCrossRefGoogle Scholar
  19. Schwartz, S. M., Benditt, E. P.: Studies on aortic intima. I. Structure and permeability of rat thoracic aortic intima. Amer. J. Path. 66, 241 (1972).PubMedGoogle Scholar
  20. Somer, J. B., Schwartz, C. J.: Focal 3H-cholesterol uptake in the pig aorta. Atherosclerosis 13, 293 (1971).PubMedCrossRefGoogle Scholar
  21. Vane, J. R.: Release and fate of vasoactive hormones in tke circulation. Br. J. Pharmacol. 35, 209 (1969).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • A. Lazzarini Robertson
  • P. A. Khairallah

There are no affiliations available

Personalised recommendations