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Effects of Angiotensin on the Renal Circulation

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Book cover Angiotensin

Abstract

The intravenous injection or infusion of renin or angiotensin produces a marked decrease in renal blood flow, a lesser decrease in glomerular filtration, and, therefore, an increase in filtration fraction (Corcoran and Page, 1939, 1940, 1941; Herrick et al., 1942; Hughes-Jones et al., 1949; Whitney et al., 1954). When the effects of bolus injections of renin and angiotensin were compared, it was found that renin in doses sufficient to cause a pressor response of approximately 60 mmHg decreased renal blood flow within 30 sec to 1 min, with the maximum effect occurring at about 2 min. This period of maximum vasoconstriction was short, and within 3 to 5 min renal blood flow returned to about one-half the control value and was maintained there for several minutes. The effects of angiotensin were more immediate and transient with the renal blood flow immediately decreasing to its minimum in less than 1 min and returning to the control value within 2 to 3 min (Herrick et al., 1941, 1942).

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Authors
  1. Luis G. Navar
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  2. Herbert G. Langford
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Editors and Affiliations

  1. The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    Irvine H. Page M.D. (Emeritus Director of Research) (Emeritus Director of Research)

  2. Division of Research, The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    F. Merlin Bumpus Ph.D. (Chairman) (Chairman)

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© 1974 Springer-Verlag Berlin · Heidelberg

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Navar, L.G., Langford, H.G. (1974). Effects of Angiotensin on the Renal Circulation. In: Page, I.H., Bumpus, F.M. (eds) Angiotensin. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65600-2_25

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  • DOI: https://doi.org/10.1007/978-3-642-65600-2_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65602-6

  • Online ISBN: 978-3-642-65600-2

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