Abstract
An important link between neurogenic and renal factors in the genesis of renal hypertension is probably to be found in the multiple actions of angiotensin on the peripheral autonomic nervous system. It is remarkable that discovery of these actions commenced only after 20 years of study of the well-known direct vasoconstrictor action of angiotensin. There was one exception, and this was the first clear demonstration that angiotensin has a direct action on the peripheral autonomic nervous system. In 1940, Braun-Menéndez et al. provided convincing evidence in cross-transfusion experiments that angiotensin can cause adrenal medullary discharge. Release of adrenal catecholamines by angiotensin receives thorough treatment in Chapter 20. The subject was then to lie dormant until recent years when the action of angiotensin on the autonomic nervous system attracted the interest of many investigators and new information is now accruing rapidly. Unfortunately, it is still too early to assess whether or not these newly discovered actions of angiotensin play an important physiologic role in cardiovascular regulation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
AMES, R. P., BORKOWSKI, A. J., SICINSKI, A. M., LARAGH, J. H.: Prolonged infusions of angiotensin II and norepinephrine and blood pressure, electrolyte balance, and aldosterone and Cortisol secretion in normal man and in cirrhosis with ascites. J. clin. Invest. 44, 1171 (1965).
BENELLI, G., DELLA BELLA, D., GANDINI, A.: Angiotensin and peripheral sympathetic nerve activity. Brit. J. Pharmacol. 22, 211 (1964).
BRAUN-MENéNDEZ, E., FASCIOLO, J. C., LELOIR, L. F., MUñOZ, J. M.: Farmacología de la hipertensina. Rev. Soc. argent. Biol. 16, 398 (1940).
CERVONI, P., REIT, E.: Interactions between angiotensin and bloodborne exogenous norepinephrine on the cat nictitating membrane in vivo. J. Pharmacol, exp. Ther. 177, 633 (1971).
DAY, M. D., OWEN, D. A. A.: The interaction between angiotensin and sympathetic vasoconstriction in the isolated artery of the rabbit ear. Brit. J. Pharmacol. 34, 499 (1968).
DAY, M. D., OWEN, D. A. A.: Potentiation of responses to endogenously released noradrenaline in the pithed rat. Arch. int. Pharmacodyn. 179, 469 (1969).
DICKINSON, C. J., LAWRENCE, J. R.: A slowly developing pressor response to small concentrations of angiotensin. Lancet 1963 I, 1354. DICKINSON, C. J., Yu, R.: Mechanism involved in the progressive pressor response to small concentrations of angiotensin. Circuiat. Res. 21, 157 (1967).
FARR, W. C., GRUPP, G.: Sympathetically mediated effects of angiotensin on dog heart in situ. J. Pharmacol, exp. Ther. 156, 528 (1967).
FARR, W. C., GRUPP, G.: Ganglionic stimulation: mechanism of the positive inotropic and chronotropic effects of angiotensin. J. Pharmacol, exp. Ther. 177, 48 (1971).
FELDBERG, W., LEWIS, G. P.: The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin. J. Physiol. (Lond.) 171, 98 (1964).
FINCH, L., LEACH, G. D. H.: The role of the sympathetic nervous system in the cardiovascular responses to angiotensin in the pithed rat. Brit. J. Pharmacol. 36, 481 (1969).
FORSYTH, R. P., HOFFBRAND, B. I., MELMON, K. L.: Hemodynamic effects of angiotensin in normal and environmentally stressed monkeys. Circulation 54, 119 (1971).
HAEFELY, W. A., HURLIMANN, A., THOENEN, H.: Effect of bradykinin and angiotensin on ganglionic transmission. Biochem. Pharmacol. 14, 1393 (1965).
ILLANES, A., PEREZ-OLEA, J., QUEVEDO, M., ORTIZ, A., LAZO, M.: Influence of angiotensin on the effects of tyramine upon the contractile force of isolated rabbit atria. J. Pharmacol, exp. Ther. 158, 487 (1967).
KANEKO, Y., TAKEDA, T., NAKAJIMA, K., UEDA, H.: Effects of angiotensin on the pressor response to tyramine in normotensive subjects and hypertensive patients. Circuiat. Res. 19, 673 (1966).
KEZDI, P., NOMURA, G.: Potentiation of sympathetic output by chronic angiotensin infusion and the effect of altered carotid sinus mechanism. Hypertension 16, 39 (1968).
KHAIRALLAH, P. A., PAGE, I. H.: Mechanism of action of angiotensin and bradykinin on smooth muscle in situ. Amer. J. Physiol. 200, 51 (1961).
KHAIRALLAH, P. A., PAGE, I. H., TURKER, R. K.: Potentiation of vascular myotropic responses by metanephrine and other noncatecholamines. Circulât. Res. 19, 538 (1966).
KRASNEY, J. A., THOMPSON, J. L., LOWE, R. P.: Cardiac effects of angiotensin injections into perfused right coronary artery. Amer. J. Physiol. 213, 134 (1967).
LAVERTY, R.: A nervously mediated action oi angiotensin in anaesthetised rats. J. Pharm. Pharmacol. 15, 63 (1963).
LEWIS, G. P., REIT, E.: The action of angiotensin and bradykinin on the superior cervical ganglion of the cat. J. Physiol. (Lond.) 179, 538 (1965).
MACHOVá, J., BOSKA, D.: A study of the action of angiotensin on the superior cervical ganglion in comparison with other ganglion stimulating agents. Europ. J. Pharmacol. 1, 233 (1967).
MCCUBBIN, J. W., DOURA, R. S., PAGE, I. H., OLMSTED, F.: Arterial hypertension elicited by subpressor amounts of angiotensin. Science 149, 1394 (1965).
MUBBIN, J. W., PAGE, I. H.: Neurogenic component of chronic renal hypertension. Science 139, 210 (1963).
MCCUBBIN, J. W., PAGE, I. H.: Renal pressor system and neurogenic control of arterial pressure. Circulât. Res. 12, 553 (1963).
MCGIFF, J. C., FASY, T. M.: The relationship of the renal vascular activity of angiotensin II to the autonomic nervous system. J. clin. Invest. 44, 1911 (1965).
MCGREGOR, D. D.: The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric blood vessels of the rat. J. Physiol. (Lond.) 177, 21 (1965).
PAGE, I. H., MUBBIN, J. W.: Mechanisms by which ganglioplegics and atropine enhance cardiovascular responsiveness. Amer. J. Physiol. 205, 1 (1963).
PANISSET, J. C.: Effect of angiotensin on release of acetylcholine from preganglionic and post-ganglionic nerve endings. Canad. J. Physiol, and Pharmacol. 45, 313 (1967).
ROBERTSON, P. A., RUBIN, D.: An indirect action of angiotensin I on smooth muscle. Nature (Lond.) 182, 867 (1958).
ROBERTSON, P. A., RUBIN, D.: Stimulation of intestinal nervous elements by angiotensin. Brit. J. Pharmacol. 19, 5 (1962).
SAKURAI, T., HASHIMOTO, Y.: The vasoconstrictor action of angiotensin in relation to catecholamine. Jap. J. Pharmacol. 15, 223 (1965).
SATO, R., MASUYAMA, Y.: Interaction of angiotensin and noradrenaline in rat’s hindlimb preparation. Jap. Circulât. J. 35, 505 (1971).
SCROOP, G. C., WHELAN, R. F.: A central vasomotor action of angiotensin in man. Clin. Sci. 30, 79 (1966).
THOENEN, H., HURLIMAN, A., HAEFELY, W.: The effect of angiotensin on the response to postganglionic sympathetic stimulation of the cat spleen; lack of facilitation of norepinephrine liberation. Med. et pharmacol. exp. 13, 379 (1965).
THOMPSON, J. L.: Effect of angiotensin on the cardioaccelerator response to sympathetic nerve stimulation in isolated rabbit hearts. Proc. Soc. exp. Biol. (N. Y.) 135, 825 (1970).
TRENDELENBURG, U.: Observations on the ganglion stimulating action of angiotensin and bradykinin. J. Pharmacol, exp. Ther. 154, 418 (1966).
Yu, R., DICKINSON, C. J.: Neurogenic effects of angiotensin. Lancet 1965 II, 1276.
ZIMMERMAN, B. G.: Effect of acute sympathectomy on responses to angiotensin and norepinephrine. Circulât. Res. 11, 780 (1962).
ZIMMERMAN, B. G., GOMEZ, J.: Increased response to sympathetic stimulation in the cutaneous vasculature in presence of angiotensin. Int. J. Neuropharmacol. 4, 185 (1965).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
McCubbin, J.W. (1974). Peripheral Effects of Angiotensin on the Autonomic Nervous System. In: Page, I.H., Bumpus, F.M. (eds) Angiotensin. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65600-2_22
Download citation
DOI: https://doi.org/10.1007/978-3-642-65600-2_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-65602-6
Online ISBN: 978-3-642-65600-2
eBook Packages: Springer Book Archive