Abstract
Since the beginning of the atomic age the overriding concern in bioassay programs has been the detection of uranium and plutonium. These nuclides have presented the chief danger of internal contamination of workers in the atomic energy industry. The irradiation of uranium and plutonium produces transplutonium elements amounting to only a few percent of the target material. These elements have, therefore, constituted a relatively small hazard incidental to the far greater danger of contamination from uranium and plutonium. Indeed, concern for the transplutonium elements as potential hazards to workers was first engendered by reports of accidental contamination with americium by Foreman et al. (1958), and by Dobson (1955), and Rowland et al. (1955). The case reported by Foreman received his exposure by inhalation. He was treated with a chelating agent (EDTA) and retention of americium was evaluated by radiochemical analysis of excreta, which was carried on for several years. The case reported by Dobson and the Rowland group received his exposure by puncture wound, and is believed to be the first instance in which both radiochemical analysis of excreta and whole body counting were used to measure retention of the isotope.
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References
Allaway, D.: Personal communication 1971.
Anger, H. O.: Sensitivity, resolution and linearity of the scintillation camera. Trans. Nucl. Sci 13, 380–392 (1966).
Auer-Welsbach, H., Bildstein, H., Mulner, P.: Chromatographische Trennung von Curium-242 und Americium-241 und die spektroskopische Überprüfung ihrer a-Aktivität. Mh. Chem. 98, 61–67 (1967).
Baybarz, D. D.: Separation of transplutonium elements by phosphonate extraction. Oak Ridge National Laboratory Report ORNL-3273 (1962).
Benes, P., Garba, A.: A radiotracer study of manganese adsorption on glass from very dilute aqueous solutions. Radiochem. Acta 5, 99–104 (1966).
Best, G. F., Hesford, E., McKay, H. A. C.: Tri-n-butyl phosphate as an extracting agent for inorganic nitrates, VII. J. Inorg. Anal. Chem. 12, 136–140 (1959).
Bosholm, J., Gosse-Ruyken, H.: J. prakt. Chem. 26, 83–89 (1964).
Brandstetr, J., Wang, T., Gabrilov, K. A., Gwozdz, E., Maly, J., Taube, M.: Extraction properties of fermium and mendelevium. Radiokhimiya 6, 22–30 (1964).
Brown, K. B.: Extraction of lanthanide and transplutonium elements by dialkyl phosphoric acid and amines. Chemical Technology Division, Chemical Development Section C, Progress Report on Separation Chemistry and Separation Research, Jan.-June, 1963, ORNL-3496.
Butler, F. E.: Determination of uranium and americium-curium in urine by liquid ion exchange. Analyt. Chem. 37, 340–342 (1965).
Butler, F. E., Hall, R. M.: Determination of actinides in biological samples with bidentate organophosphorus compounds. Analyt. Chem. 42, 1073–1076 (1970).
Choppin, G. R., May, D., Holm, L. W.: Ion exchange studies of alpha-hydroxy carboxylic acid—lanthanide and actinide systems. In: Radioisotopes in the physical sciences and industry, vol. 111, p. 283–299. Vienna: IAEA 1962.
Coleman, J. S., Penneman, R. A., Keenan, T. K., Lamar, L. E., Armstrong, D. E., Asprey, L. B.: An ion exchanger process for gram scale separation of americium from rare earths. J. Inorg. Nucl. Chem. 3, 327–328 (1956).
Crouthamel, E. E.: Applied gamma ray spectrometry, 2nd ed. (Adams and Dam, eds.). New York-Oxford: Pergamon Press 1970.
Deal, R. A., Chanda, R. N.: A rapid source preparation technique for high resolution alpha particle spectroscopy. Nucl. Instr. Meth. 69, 88–92 (1969).
Diamond, R. M., Street, K., Jr., Seaborg, G. T.: An ion exchange study of possible hybridized 5f bonding in the actinides. J. Amer. chem. Soc. 76, 1461–1469 (1954).
Dobson, R. L.: Americium poisoning-therapy of radioelement poisoning. ANL-5584, p. 28-35 (1955).
Donnan, M. Y., Dukes, E. K.: Carrier technique for quantitative electrodeposition of actinides. Analyt. Chem. 36, 392–394 (1964).
Drexler, G., Perzl, F.: Spectrometry of low-energy y and x-rays with Ge(Li) detectors. Nucl. Instr. Meth. 48, 332–334 (1967).
Eakins, J. D., Gomm, P. J.: The determination of gross alpha activity in urine by adsorption on glass filter paper. Hlth Phys. 14, 461–472 (1968).
Fine, S., Hendee, C. F.: X-ray critical-absorption and emission energies in keV. In: Radiological health handbook, Rev. ed., p. 162. U.S. Department of Health, Education and Welfare, Public Health Service, 1970.
Foreman, H., Moss, W., Ensetter, B. C.: Clinical experiences with radioactive materials. Amer. J. Roentgenol. 79, 1071–1079 (1958).
Fuger, J.: Ion exchange behavior and dissociation constants of Am, Cm, and Cf complexes with EDTA. J. Inorg. Nucl. Chem. 5, 332–338 (1958).
Fuger, J.: Preparation of thin electrodeposits of actinides from aqueous solutions of EDTA. Bull. Soc. chim. Belg. 71, 134–141 (1962).
Gatti, R. C., Phillips, L., Sikkeland, T., Muga, M. L., Thompson, S. G.: Ion exchange behavior of mendelavium. J. Inorg. Nucl. Chem. 11, 251–253 (1959).
Gray, P. R., Thompson, S. G.: Lawrence Radiation Laboratory, Berkeley, Chemistry Division Quarterly Report, Sept.-Nov., 1952, UCRL-2069.
Gureev, E. S., Dedov, V. B., Karpachava, S. M., Lebedev, I. A., Shvetsov, I. D., Yako-Lev, M., Rhyzov, N., Trukchlayev, P. S.: Proc. Third Int. Conf. Peaceful Uses of Atomic Energy, p. 553–560. Geneva: IAEA, 1964.
Harley, J. H.: Sampling and analysis for assessment of body burdens. In: Assessment of radioactivity in man, vol. 1, p. 155–167. Vienna: IAEA 1964.
Harris, D. H., Tompkins, E. R.: Separations of several rare earths of the curium group. J. Amer. chem. Soc. 69, 3792–3800 (1947).
Henley, L. C.: Urinalysis by ion exchange. Proc. 11th Annual Bioassay and Analytical Chemistry Meeting, Albuquerque, N. M., 1965, Conf.-651008, Biology and Medicine, USAEC TID-4500, p. 1–19.
Hesford, E., Jackson, E. E., McKay, H. A. C.: Tri-n-butyl phosphateas an extracting agent for inorganic nitrates—VI. J. Inorg. Nucl. Chem. 9, 279–289 (1959).
Hill, O. F., Cooper, V. R.: Scale-up problems in the Pu separations program. Ind. Eng. Chem. 50, 599–602 (1958).
Horowitz, E. P., Bloomquist, C. A. A., Henderson, J. D.: The extraction chromatography of californium, einsteinium and fermium with di(2-ethylhexyl)-orthophosphoric acid. J. Inorg. Nucl. Chem. 31, 1149–1166 (1969).
Hulet, E. K.: An investigation of the extraction chromatography of Am (VI) and Bk (IV). J. Inorg. Nucl. Chem. 26, 1721–1726 (1964).
Hyde, E. K.: Radiochemical separations of the actinide elements. In: The actinide elements. National Nuclear Energy Series Div. IV., vol. 14A, p. 542–595 (Seaborg and Katz, eds.). New York: McGraw-Hill 1954.
Isaac, N. M., Wilkins, J. W., Field, P. R.: Separation of transcurium elements from large quanities of Cm by liquid-liquid extraction. J. Inorg. Nucl. Chem. 15, 151–157 (1960).
Ketelle, B. H., Boyd, G. E.: Exchange adsorption of ions from aqueous solutions by organic zeolites. IV. Separation of the Y group rare earths. J. Amer. chem. Soc. 69, 2800–2812 (1947).
Kooi, J., Boden, R., Wikstra, J.: Separation of Am(Cm), Bk, and Cf by extraction chromatography. J. Inorg. Nucl. Chem. 26, 2300–2302 (1964).
Lawroski, S.: Survey of separations process other than solvent recovery. Chem. Eng. Prog. 51, 461–466 (1955).
Lederer, C. M., Hollander, J. M., Perlman, I.: Table of isotopes, 6th ed. New York: John Wiley & Sons, Inc. 1967.
Lieser, K. H.: Kationenaustausch und Adsorption von Radionukliden an Glasoberflachen. Radiochim. Acta 4, 225–227 (1965).
Low-Beer, A. De G., Story, T. L., Jr.: A method for determining low level alpha activity from Am, Cm and Cf in biological materials. Proc. 8th Annual Bioassay and Analytical Chemistry Meeting, DP-831, p. 58–63 (1962).
Magnuson, L. B., Anderson, M. L.: Chelation of the +3 ions of elements 95 through 100 with thenoyltrifluoroacetone. J. Amer. chem. Soc. 76, 6207 (1954).
Marcus, Y., Givon, M.: Anion exchange of metal complexes XIII the actinide (III)—nitrate system. IAR (1962).
May, H. A., Marinelli, L. D.: Sodium iodide systems: Optimum crystal dimensions and origin of background. In: Whole body counting, p. 15–36. Vienna: IAEA 1962.
Mehl, H. G., Rundo, J.: Preliminary results of a world survey of whole body monitors. Hlth Phys. 9, 607–614 (1963).
Mellish, C. E., Hill, M. R., Glanville, D. E.: UKAEA Report AERE-R-5323 (1966).
Miller, C. E., Marinelli, L. D.: ANL-4531 (1950) 77 pages.
Mitchell, R. F.: Electrodeposition of actinide elements at tracer concentrations. Analyt. Chem. 32, 326–328 (1960).
Moore, F. L.: Separation of Am from other elements: Application to the purification and radiochemical determination of Am. Analyt. Chem. 35, 715–719 (1963).
Mueller, W., Fuger, J., Duyckaerts, G.: Complex formation in tertiary amine extraction of trivalent metals. 8th Int. Conf. on Coordination Chemistry, Vienna (1964), Euratom 2169e.
National Council on Radiation Protection and Measurements Reports No 33 (1968) and No 39 (1971 ), Washinton, D.C.
National Research Council, National Academy of Science: The radiochemistry of americium and curium. NAS-NS-3006 (1960).
National Research Council, National Academy of Science: The radiochemistry of the transcurium elements. NAS-NS-3031 (1960).
Parker, H. G., Wright, S. R.: Whole-body counting of 241Am and 262Cf with the Anger camera. Health Phys., 22, 891–898 (1972).
Parker, H. G., Wright, S. R., Low-Beer, A. De G., Yaeger, D. J.: The metabolism of 253Es in mice. Health Phys., 22, 641–652 (1972).
Peppard, D. F., Mason, G. W., Driscoll, W. J., Mccarty, S.: Application of phosphoric acid esters to the isolation of certain transplutonides by liquid-liquid extraction. J. Inorg. Nucl. Chem. 12, 141–149 (1959).
Perlman, I., Street, K., Jr.: The chemistry of the transplutonium elements. In: The actinide elements, National Nuclear Energy Series Div. IV, vol. 14 A, p. 507–541 (Seaborg and Katz, eds.). New York: McGraw-Hill 1954.
Pierce, T. B., Peck, P. F.: Use of di(2-ethylhexyl) orthophosphoric acid for the separation of the rare earths by reverse phase partition chromatography. Nature (Lond.) 195, 597 (1962).
Poskanzer, A.M., Foreman, B. M., Jr.: A summary of TTA extraction coefficients. J. Inorg. Nucl. Chem. 16, 323–336 (1961).
Rowland, R. E., Miller, E. C., Marinelli, L. D.: An americium accident. ANL-5518, p. 46-48 (1956).
Schieferdecker, H.: A method for separation of Am, Cm and Cf. KFK-80 (1968).
Schreck, H.: Complexing and extraction of trivalent actinium, americium, curium and californium with acetyl acetone and several of its derivatives. Kernforschungszentrum, Karlsruhe KFK-672, 83 pages (1967).
Schubert, J., Myers, L. S., Jr., Jackson, J. A.: Analytical procedures of the Bioassay Group at the Argonne National Laboratory. ANL-4509 (1951).
Schubert, J., Myers, L. S., Jr., Jackson, J. A.: Analytical procedures of the Bioassay Group at the Argonne National Laboratory. ANL-4509 (1951).
Seaborg, G. T.: Correlation of properties of actinide transition series. In: The actinide elements. National Nuclear Energy Series Div. IV, vol. 14A, p. 733–768 (Seaborg and Katz, eds.). New York: McGraw-Hill 1954.
Seaborg, G. T., James, R. A., Ghiorso, A.: The new element curium (atomic number 96). In: Transuranium elements. National Nuclear Energy Series Div. IV, vol. 14B, p. 1554–1585 (Seaborg and Katz, eds.). New York: McGraw-Hill 1949.
Sementsova, A. K.: Electrolytic precipitation of Am and Cm from their aqueous solutions onto a Pt cathode. Radiokhimiya 4, 669–671 (1962).
Siekierski, S., Sochacka, R. J.: Reversed phase partition chromatography with HDEHP as the stationary phase. Part I. Separation of rare earths. J. Chromatogr. 16, 376–384 (1964).
Sill, C. W.: Separation and radiochemical determination of uranium and the transuranium elements using barium sulfate. Hlth Phys. 17, 89–107 (1969).
Snyder, W. S.: Mathematical models for internal dose-americium and californium. Presented at Annual Health Physics Society Meeting, July 1971, New York.
Spiers, F. W.: Whole-body counting: An introductory review. In: Whole body counting, p. 3–12. Vienna: IAEA 1962.
Stary, J.: Separation of transplutonium elements. Talanta 13, 421–437 (1966).
Street, K., Jr., Higgins, G. H., Seaborg, G. T.: The separation of americium and curium from the rare earth elements. J. Amer. chem. Soc. 72, 2790–2797 (1950).
Surls, J. P., Choppin, G. R.: Equilibrium absorption of lanthanides, americium and curium on Dowex 50 resin. J. Amer. chem. Soc. 79, 855–859 (1957).
Thompson, S. G., Harvey, B. H., Choppin, G. R., Seaborg, G. T.: Chemical properties of elements 99 and 100. J. Amer. chem. Soc. 76, 6229–6236 (1954).
Thompson, S. G., Morgan, L. O., James, R. A., Perlman, I.: The tracer chemistry of americium and curium in aqueous solutions. In: The transuranium elements. National Nuclear Energy Series Div. IV, vol. 14B, p. 1339–1362 (Seaborg and Katz, eds.). New York: McGraw-Hill 1949.
U. S. Atomic Energy Commission: Californium-252. Proc. of a Symposium American Nuclear Society, New York, 1968. Conf. 681032, p. 41.
Vandilla, M. A., Anderson, E. C.: Human counters using liquid scintillators. In: Whole body counting, p. 41–58. Vienna: IAEA 1962.
Vouech, O., Spicin, V. I.: Dokl. Akad. Nauk. SSSR 136, 339–341 (1961).
Werner, L. B., Perlman, I.: The preparation and isolation of curium. In: Transuranium elements. National Nuclear Energy Series Div. IV, vol. 14B, p. 1586–1654 (Seaborg and Katz, eds.). New York: McGraw-Hill 1949.
Wright, S. R., Parker, H. G.: Unpublished material (1971).
Yakovlev, G. N., Chulkov, P. M., Dedov, V. M., Kosyskov, V. N., Sobelev, Y. P.: The preparation of thin films of Pu, Am, and Cm by an electrolytic method. J. Nucl. Energy 5, No 1, 159–161 (1957).
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Low-Beer, A.D.G. (1973). Bioassay of Transplutonium Elements. In: Hodge, H.C., Hursh, J.B., Stannard, J.N. (eds) Uranium · Plutonium Transplutonic Elements. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65551-7_20
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