Skip to main content
SpringerLink
Log in

Antigenic Competition

  • Conference paper
Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 60))

Abstract

The term antigenic competition dates back as far as 1904 when it was introduced by LEONOR MICHAELIS in connection with the raising of antibodies to serum proteins. In 1902 he had shown that the main result of injection of foreign serum into rabbits was the production of antibodies against globulins, and that in order to obtain anti-albumin it was necessary to inject the relatively purified albumin alone. He concluded that the response to the serum globulin had inhibited the response to serum albumin. MICHAELIS put it thus in the terminology of the time:

“Ein Haptin hindert also in diesem Fall ein zweites, gleichzeitig injiziertes, mit verschiedener haptophorer Gruppe versehenes Haptin an der Entfaltung seiner Antikörper erzeugenden Eigenschaften. Ich möchte dies das Prinzip von der Konkurrenz der Haptine nennen”

(Michaelis, 1904).

Article Note

Part of the work described here was carried out while the author was holder of a long term fellowship of the European Molecular Biology Organisation, in Rehovot.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ada, G. L., Nossal, G. J. V., Austin, C. M.: Antigens in immunity. V. The ability of cells in lymphoid follicles to recognise foreigness. Aust. J. exp. Biol. med. Sci. 42, 331–346 (1964).

    PubMed  CAS  Google Scholar 

  • Adler, F. L.: Competition of antigens. In: H. Shaffer, G. A. Logrippo and M. W. Chase, Eds., Mechanisms of hypersensitivity, p. 539–546. Boston: Little, Brown & Co. 1959.

    Google Scholar 

  • Adler, F. L.: Competition of antigens. Progr. Allergy 8, 41–57 (1964).

    CAS  Google Scholar 

  • Albright, J. F., Makinodan, T.: Dynamics of expression of competence of antibody-producing cells. In: J. Sterzl, ed., Molecular and cellular basis of antibody formation, p. 427–446. New York: Academic Press 1965.

    Google Scholar 

  • Albright, J. F., Omer, T. F., Deitchman, J.W.: Antigenic competition: antigens compete for a cell occurring with limited frequency. Science 167, 196–198 (1970).

    PubMed  CAS  Google Scholar 

  • Ambrose, C. T.: Regulation of the secondary antibody response in vitro. Enhancement by actinomycin D and inhibition by a macromolecular product of stimulated lymph node cultures. J. exp. Med. 130, 1003–1029 (1969).

    PubMed  CAS  Google Scholar 

  • Amkraut, A. A., Garvey, J. S., Campbell, D. H.: Competition of haptens. J. exp. Med. 124, 293–306 (1966).

    PubMed  CAS  Google Scholar 

  • Ashley, H., Ovary, Z.: Effect of bovine gamma globulin on subsequent immunisation with dinitrophenylated bovine gamma globulin. Proc. Soc. exp. Biol. (N.Y.) 119, 311–314 (1965).

    CAS  Google Scholar 

  • Barr, M., Llewellyn-Jones, M.: Some factors influencing the response of animals to immunisation with combined prophylactics. Brit. J. exp. Path. 34, 12–22 (1953a).

    PubMed  CAS  Google Scholar 

  • Barr, M., Llewellyn-Jones, M.: Interference with antitoxic responses in immunisation with combined prophylactics. Brit. J. exp. Path. 34, 233–240 (1953b).

    PubMed  CAS  Google Scholar 

  • Barr, M., Llewellyn-Jones, M.: Some factors influencing the response to immunisation with single and combined prophylactics. Brit. J. exp. Path. 36, 147–154 (1955).

    PubMed  CAS  Google Scholar 

  • Basten, A., Sprent, J., Miller, J. F. A. P.: Receptor for antibody-antigen complexes used to separate T cells from B cells. Nature (Lond.) New Biol. 235, 178–180 (1972).

    CAS  Google Scholar 

  • Bauminger, S., Schechter, I., Sela, M.: Specificity of immunological tolerance to poly-DL-alanyl proteins. Immunochemistry 4, 169–181 (1967).

    PubMed  CAS  Google Scholar 

  • Benacerraf, B., Green, I., Bluestein, H. G., Elman, L.: Specific immune responses of guinea pigs. In: Amos, D. B. (ed.), Progress in immunology, vol. 1, p. 487–494. New York: Academic Press 1971.

    Google Scholar 

  • Ben-Efraim, S., Liacopoulos, P.: Inhibition, no effect or enhancement of immune response following injections of mixtures of immunogenic and non-immunogenic synthetic polypeptides. Immunology 12, 517–524 (1967a).

    PubMed  CAS  Google Scholar 

  • Ben-Efraim, S., Liacopoulos, P.: Inhibition of delayed hypersensitivity in guinea pigs after competition between synthetic antigens. Nature (Lond.) 213, 711–713 (1967b).

    CAS  Google Scholar 

  • Ben-Efraim, S., Liacopoulos, P.: The competitive effect of DNP-poly-L-lysine in responder and non-responder guinea pigs. Immunology 16, 573–580 (1969).

    PubMed  CAS  Google Scholar 

  • Ben-Efraim, S., Liacopoulos, P., Harel, S., Gille, F.: The immune response to DNP-poly-L-lysine in randomly bred guinea pigs and its relation to antigenic competition. In: H. PEETERS (ed.), Protides of the biological fluids, 17th Colloquium, p. 181–183 (1970).

    Google Scholar 

  • Braun, W., Ishizuka, M., Winchurch, R., Webb, D.: Cells and signals in immuonlogical non-responsiveness. In: Tolerance to microbial antigens, ed. H. Friedman, Ann. N.Y. Acad. Sci. 181, 289–300 (1971).

    Google Scholar 

  • Bretscher, P. A., Cohn, M.: Minimal model for the mechanism of antibody induction and paralysis by antigen. Nature (Lond.) 220, 444–448 (1968).

    CAS  Google Scholar 

  • Bretscher, P., Cohn, M.: A theory of self-nonself discrimination. Science 169, 1042–1049 (1970).

    PubMed  CAS  Google Scholar 

  • Brody, N., Walker, J. G., Siskind, G. W.: Studies on the control of antibody synthesis. Interaction of antigenic competition and suppression of antibody formation by passive antibody on the immune response. J. exp. Med. 126, 81–91 (1967).

    PubMed  CAS  Google Scholar 

  • Brody, N. I., Siskind, G. W.: Studies on antigenic competition. J. exp. Med. 130, 821–832 (1969).

    PubMed  CAS  Google Scholar 

  • Brody, N. I., Siskind, G. W.: Studies on antigenic competition. II. Evidence for effect at level of antigen ‘processing’. Immunology 22, 75–86 (1972).

    PubMed  CAS  Google Scholar 

  • Bussard, A. E.: Difficulties of clonal selection. In: J. Sterzl and I. Riha, eds., Developmental aspects of antibody formation and structure, p. 983–989. New York-London: Academic Press 1971.

    Google Scholar 

  • Celada, F.: The cellular basis of immunologic memory. Progress Allergy 15, 223–267 (1971).

    CAS  Google Scholar 

  • Celada, F., Ellis, J., Bodlund, K., Rotman, B.: Antibody-mediated activation of a defective-D-glactosidase. II. Immunological relationship between the normal and defective enzyme. J. exp. Med. 134, 751–764 (1971).

    PubMed  CAS  Google Scholar 

  • Cockburn, W. C.: World problems in viral vaccines. In: D. G. Evans, ed., Immunisation against infectious diseases. Brit. med. Bull. 25, 121–125 (1969).

    Google Scholar 

  • Coe, J. E., Salvin, S. B.: The immune response in the presence of delayed hypersensitivity or circulating antibody. J. Immunol. 93, 495–510 (1964).

    PubMed  CAS  Google Scholar 

  • Cohn, M., Notani, G., Rice, S. A.: Characterisation of the antibody to the C-carbohydrate produced by a transplantable mouse plasmacytoma. Immunochemistry 6, 111–123 (1969).

    PubMed  CAS  Google Scholar 

  • Cooperband, S. R., Bondevick, H., Schmid, K., Mannick, J. A.: Transformation of human lymphocytes: inhibition by homologous alpha globulin. Science 159, 1243–1244 (1968).

    PubMed  CAS  Google Scholar 

  • Dennert, G., Pohlit, H., Rajewsky, K.: Co-operative antibody: a concentrating device. In: Makela, O., A. Cross and T. U. Kosunen, Eds., Cell interactions and receptor antibodies in immune responses, p. 3–7. London-New York: Academic Press 1971.

    Google Scholar 

  • Dent, P. B., Peterson, R. D. A., Good, R. A.: A defect in cellular immunity during the incubation period of passage A leukaemia in C3H mice. Proc. exp. Biol. (N.Y.) 119, 869–871 (1965).

    CAS  Google Scholar 

  • Dresser, D. W., Mitchison, N. A.: The mechanism of immunological paralysis. Advanc. Immunol. 8, 129–181 (1968).

    CAS  Google Scholar 

  • Dubert, J.-M.: Sur la nature de la reponse secondaire. C. R. Acad. Sci. (Paris) 243, 1939–1941 (1956).

    CAS  Google Scholar 

  • Dukor, P., Bianco, C., Nussenzweig, Y.: Tissue localisation of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. Proc. nat. Acad. Sci. (Wash.) 67, 991–997 (1970).

    CAS  Google Scholar 

  • Dukor, P., Dietrich, F. M.: The immune response to heterologous red cells in mice. V. The effect of cyclophosphamide and cortisone on antigenic competition. J. Immunol. 105, 118–125 (1970).

    PubMed  CAS  Google Scholar 

  • Dutton, R. W.: In: J. Uhr and M. Landy, eds., Immunologic intervention, p. 66–70. New York: Academic Press 1971.

    Google Scholar 

  • Eidinger, D., Khan, S. A., Millar, K. G.: The effect of antigenic competition on various manifestations of humoral antibody formation and cellular immunity. J. exp. Med. 128, 1183–1200 (1968).

    PubMed  CAS  Google Scholar 

  • Eisen, H. N., Little, J. R., Steiner, L. A., Simms, E. S., Gray, W.: Degeneracy in the secondary immune response: stimulation of antibody formation by cross-reacting antigens. Israel J. med. Sci. 5, 338–351 (1969).

    PubMed  CAS  Google Scholar 

  • Fauci, A. S., Johnson, J. S.: Suppression of antibody synthesis. I. Evidence for a circulating inhibitor of antibody synthesis demonstrable at the cellular level. J. Immunol. 107, 1052–1056 (1971a).

    PubMed  CAS  Google Scholar 

  • Fauci, A. S., Johnson, J. S.: Suppression of antibody synthesis. II. The effect of carrier- specific cells upon haptenic competition. J. Immunol. 107, 1057–1062 (1971b).

    PubMed  CAS  Google Scholar 

  • Fazekas De St. Groth, S.: Cross-recognition and cross-reactivity. Cold Spr. Harb. Symp. quant. Biol. 32, 525–536 (1967).

    Google Scholar 

  • Fazekas De St. Groth, S., Webster, R. G.: Disquisitions on original antigenic sin. I. Evidence in man. J. exp. Med. 124, 331–345 (1966a).

    Google Scholar 

  • Fazekas De St. Groth, S., Webster, R.G.: Disquisitions on original antigenic sin. II. Proof in lower creatures. J. exp. Med. 124, 347–361 (1966b).

    Google Scholar 

  • Frei, P. C., Benacerraf, B., Thorbecke, G. J.: Phagocytosis of antigen, a crucial step in the induction of the primary response. Proc. nat. Acad. Sci. (Wash.) 53, 20–23 (1965).

    CAS  Google Scholar 

  • Friedberger, E.: Über die Intensität der Choleramboceptorenbildung beim Kaninchen unter dem Einflüsse der Alkoholisierung und der Mischung. Berl. klin. Wschr. 41, 242 (1904).

    Google Scholar 

  • Friedman, H., Ceglowski, W. S.: Cellular basis for the immunosuppressive properties of a leukemogenic virus. Nature (Lond.) 218, 1232–1234 (1968).

    CAS  Google Scholar 

  • Fuchs, S., Sela, M.: Antigenicity of some new synthetic polypeptides and polypeptidyl gelatins. Biochem. J. 93, 566–572 (1964).

    PubMed  CAS  Google Scholar 

  • Gershon, R. K., Kondo, K.: Antigenic competition between heterologous erythrocytes. Thymic dependency. J. Immunol. 106, 1524–1531 (1971a).

    PubMed  CAS  Google Scholar 

  • Gershon, R. K., Kondo, K.: Antigenic competition between heterologous erythrocytes. Effect of passive antibody administration. J. Immunol. 106, 1532–1539 (1971b).

    PubMed  CAS  Google Scholar 

  • Greaves, M. F., Moller, E., Moller, G.: Studies on antigen-binding cells. II. Relationship to antigen-sensitive cells. Cell Immunol. 1, 386–403 (1970).

    PubMed  CAS  Google Scholar 

  • Hanna, M. G., Peters, L. C.: The effect of antigenic competition on both the primary and secondary immune capacity in mice. J. Immunol. 104, 166–177 (1970).

    PubMed  CAS  Google Scholar 

  • Henney, C. S.: The specificity of the early immune response. I. A comparison of the specificity of delayed hypersensitivity and humoral responses following immunisation with human globulin. J. Immunol. 103, 519–527 (1969).

    PubMed  CAS  Google Scholar 

  • Henry, C., Jerne, N. K.: Competition of 19S and 7S antigen receptors in the regulation of the primary immune response. J. exp. Med. 128, 133–152 (1968).

    PubMed  CAS  Google Scholar 

  • Howard, J. G., Woodruff, M. F. A.: Effect of the graft-versus-host reaction on the immunological responsiveness of the mouse. Proc. roy. Soc. B 154, 532–539 (1961).

    Google Scholar 

  • Humphrey, J. H., Frank, M. M.: The localisation of non-microbial antigens in the draining lymph nodes of tolerant, normal and primed rabbits. Immunology 13, 87–100 (1967).

    PubMed  CAS  Google Scholar 

  • International symposium on combined vaccines. Symp. series immunobiol. standard. Basel-New York: Karger 1967.

    Google Scholar 

  • Iverson, G. M.: Ability of CBA mice to produce anti-idiotypic sera to 5563 myeloma protein. Nature (Lond.) 227, 273–274 (1970).

    CAS  Google Scholar 

  • Jaton, J.-C., Sela, M.: Role of optical configuration in the immunogenicity and specificity of synthetic antigens derived from multichain polyproline. J. biol. Chem. 243, 5616–5626 (1968).

    PubMed  CAS  Google Scholar 

  • Jerne, N. K.: The problem of antigen competition. In: International symposium on combined vaccines, p. 1–6. Basel-New York: Karger 1967.

    Google Scholar 

  • Jerne, N. K.: The somatic generation of immune recognition. Europ. J. Immunol. 1, 1–9 (1971).

    CAS  Google Scholar 

  • Kappler, J. W., Hoffmann, M., Dutton, R. W.: Regulation of the immune response. I. Differential effect of passively administered antibody on the thymus-derived and bone marrow-derived lymphocytes. J. exp. Med. 134, 577–587 (1971).

    PubMed  CAS  Google Scholar 

  • Katz, D. H., Paul, W. E., Goidl, E. A., Benacerraf, B.: Carrier function in antihapten immune responses. I. Enhancement of primary and secondary anti-hapten antibody response by carrier preimmunisation. J. exp. Med. 132, 261–282 (1970).

    PubMed  CAS  Google Scholar 

  • Kerbel, R. S., Eidinger, D.: Further studies of antigenic competition. III. A model to account for the phenomenon based on a deficiency of cell-to-cell interaction in immune lymphoid cell populations. J. exp. Med. 133, 1043–1060 (1971).

    PubMed  CAS  Google Scholar 

  • Kreth, H. W., Williamson, A. R.: Cell surveillance model for lymphocyte cooperation. Nature (Lond.) 234, 454–456 (1971).

    CAS  Google Scholar 

  • Lapp, W. S., Möller, G.: Prolonged survival of H-2 incompatible skin allografts on Ft animals treated with parental lymphoid cells. Immunology 17, 339–344 (1969).

    PubMed  CAS  Google Scholar 

  • Lawrence, W., Simonsen, M.: The property of ‘strength’ of histocompatibility antigens and their ability to produce antigenic competition. Transplantation 5, 1304–1322 (1967).

    PubMed  Google Scholar 

  • Liacopoulos, P., Couderc, J., Gille, M. F.: Competition of antigens during induction of low zone tolerance. Europ. J. Immunol. 1, 359–363 (1971).

    CAS  Google Scholar 

  • Liacopoulos, P., Halpern, N. B., Perament, F.: Unresponsiveness to unrelated antigens induced by paralysing doses of bovine serum albumin. Nature (Lond.) 195, 1112–1113 (1962).

    CAS  Google Scholar 

  • Liacopoulos, P., Neveu, T.: Non-specific inhibition of the immediate and delayed types of hypersensitivity during immune paralysis of adult guinea pigs. Immunology 7, 26–39 (1964).

    PubMed  CAS  Google Scholar 

  • Lindenmann, J.: Cross-priming and cross-inhibition by antibody in the influenza virus- host antigen system. Proc. roy. Soc. B 176, 419–423 (1971).

    CAS  Google Scholar 

  • Mäkelä, O., Cross, A., Kosunen, T. U. (eds.): Cell interactions and receptor antibodies in immune responses. London-New York: Academic Press 1971.

    Google Scholar 

  • McBride, R. A., Schierman, L. W.: Hapten-carrier relationships of isoantigens. A model for immunological maturation based on the conversion of haptens to carriers by antibody. J. exp. Med. 131, 377–390 (1970).

    PubMed  CAS  Google Scholar 

  • McDevitt, H. O., Benacerraf, B.: Genetic control of specific immune responses. Advanc. Immunol. 11, 31–74 (1969).

    CAS  Google Scholar 

  • Metcalf, D.: Reticular tumours in mice subjected to prolonged antigenic stimulation. Brit. J. Cancer 15, 769–779 (1961).

    PubMed  CAS  Google Scholar 

  • Michaelis, L.: Untersuchungen über Eiweißpräzipitine. Dtsch. med. Wschr. 28, 733–736 (1902).

    Google Scholar 

  • Michaelis, L.: Weitere Untersuchungen über Eiweißpräzipitine. Dtsch. med. Wschr. 30, 1240–1241 (1904).

    Google Scholar 

  • Mishell, R. I., Dutton, R. W.: Immunisation of dissociated spleen cell cultures from normal mice. J. exp. Med. 126, 423–442 (1967).

    PubMed  CAS  Google Scholar 

  • Mitchison, N. A.: Antigen recognition responsible for the induction in vitro of the secondary response. Cold Spr. Harbor Symp. quant. Biol. 32, 431–439 (1967).

    CAS  Google Scholar 

  • Mitchison, N. A.: The dosage requirements for immunological paralysis by soluble proteins. Immunology 15, 509–530 (1968).

    PubMed  CAS  Google Scholar 

  • Mitchison, N. A.: The immunogenic capacity of antigen taken up by peritoneal exudate cells. Immunology 16, 1–14 (1969a).

    PubMed  CAS  Google Scholar 

  • Mitchison, N. A.: In: S. Lawrence and M. Landy (eds.), Mediators of cellular immunity, p. 97. New York: Academic Press 1969b.

    Google Scholar 

  • Mitchison, N. A.: The carrier effect in the secondary response to haptenprotein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis. Europ. J. Immunol. 1, 10–17 (1971a).

    CAS  Google Scholar 

  • Mitchison, N. A.: The carrier effect in the secondary response to haptenprotein conjugates. II. Cellular cooperation. Europ. J. Immunol. 1, 18–26 (1971b).

    CAS  Google Scholar 

  • Mitchison, N. A., Rajewsky, K., Taylor, R. B.: Cooperation of antigenic determinants and of cells in the induction of antibodies. In: J. Sterzl and M. Riha, eds., Developmental aspects of antibody formation and structure, p. 547–561. New York: Academic Press 1971.

    Google Scholar 

  • Möller, G.: Suppressive effect of graft versus host reactions on the immune response to heterologous red cells. Immunology 20, 597–609 (1971).

    PubMed  Google Scholar 

  • Möller, G., Siöberg, O.: Effect of antigenic competition on antigensensitive cells and on adoptively transferred immunocompetent cells. Cellular Immunology 1, 110–121 (1970).

    PubMed  Google Scholar 

  • Möller, G., Sjöberg, O.: Studies on the mechanism of antigenic competition. In: Mäkelä, O., A. Cross and T. U. Kosunen (eds.), Cell interactions and receptor antibodies in immune responses, p. 419–432. London and New York: Academic Press 1971.

    Google Scholar 

  • Mowbray, J. F.: Ability of large doses of an alpha2 plasma protein fraction to inhibit production. Immunology 6, 217–225 (1963).

    PubMed  CAS  Google Scholar 

  • Mozes, E., Mevitt, H. O., Jaton, J.-C., Sela, M.: The nature of the antigenic determinant in a genetic control of the antibody response. J. exp. Med. 130, 493–504 (1969a).

    PubMed  CAS  Google Scholar 

  • Mozes, E., Mevitt, H. O., Jaton, J.-C., Sela, M.: The genetic control of antibody specificity. J. exp. Med. 130, 1263–1278 (1969b).

    PubMed  CAS  Google Scholar 

  • Mozes, E., Shearer, G. M.: Contribution of bone marrow cells and lack of expression of thymocytes in genetic controls of immune responses for two immunopotent regions within poly-(Phe, Glu)-poly-Pro-poly-Lys in inbred mouse strains. J. exp. Med. 134, 141–161 (1971).

    PubMed  CAS  Google Scholar 

  • Mozes, E., Shearer, G. M., Sela, M.: Cellular basis of the genetic control of immune responses to synthetic polypeptides. I. Differences in frequency of splenic precursor cells specific for a synthetic polypeptide derived from multichain polyproline, (T, G)-Pro-L, in high and low responder inbred mouse strains. J. exp. Med. 132, 613–622 (1970).

    PubMed  CAS  Google Scholar 

  • Mozes, E., Shearer, G. M., Sela, M., Braun, W.: Conversion with polynucleotides of a genetically controlled low immune response to a high response in mice immunised with a synthetic polypeptide antigen. In: Beers, R. F. and W. Braun, eds., Biological effects of polynucleotides, p. 197–213. New York: Springer 1971.

    Google Scholar 

  • Nisbet, N. W., Simonsen, M., Zaleski, M.: The frequency of antigensensitive cells in tissue transplantation. J. exp. Med. 129, 459–467 (1969).

    PubMed  CAS  Google Scholar 

  • Nossal, G. J. Y., Ada, G. L.: Antigens, lymphoid cells and the immune response. New York and London: Academic Press 1971.

    Google Scholar 

  • Oakley, C. L.: Prophylaxis of microbial diseases. In: P. G. H. Gell and R. R. A. Coombs (eds.), Clinical aspects of immunology, 2nd ed. Oxford: Blackwells 1968.

    Google Scholar 

  • Ovary, Z., Benacerraf, B.: Immunological specificity of the secondary response with dinitrophenylated proteins. Proc. Soc. exp. Biol. Med. (N.Y.) 114, 72–75 (1963).

    CAS  Google Scholar 

  • Paraskevas, F., Orr, K. B., Anderson, E. D., Lee, S.-T., Israels, L. G.: The biologic significance of Fc receptor on mouse B-lymphocytes. J. Immunol. 108, 1729—1732 (1972).

    PubMed  CAS  Google Scholar 

  • Parish, H. J., Cannon, D. A.: Antisera, toxoids, vaccines and tuberculins in prophylaxis and treatment, 6th ed. Edinburgh: E. and S. Livingstone 1962.

    Google Scholar 

  • Pearlman, D. S.: The influence of antibodies on immunologic responses. I. The effect on the response to particulate antigens in the rabbit. J. exp. Med. 126, 127–148 (1967).

    PubMed  CAS  Google Scholar 

  • Peterson, R. D. A., Hendrickson, R., Good, R. A.: Reduced antibodyforming capacity during the incubation period of passage A leukaemia in C3H mice. Proc. Soc. exp. Biol. (N.Y.) 114, 517–520 (1963).

    CAS  Google Scholar 

  • Pincus, C. S., Lamm, M. E., Nussenzweig, V.: Regulation of the immune response: suppressive and enhancing effects of passively administered antibody. J. exp. Med. 133, 987–1003 (1971).

    PubMed  CAS  Google Scholar 

  • Pincus, C. S., Nussenzweig, V.: Passive antibody may simultaneously suppress and stimulate antibody formation against different portions of a protein molecule. Nature (Lond.) 222, 594–596 (1969).

    CAS  Google Scholar 

  • Radovich, J., Talmage, D. W.: Antigenic competition: cellular or humoral. Science 158, 512–514 (1967).

    PubMed  CAS  Google Scholar 

  • Rajewsky, K., Rottlánder, E.: Tolerance specicity and the immune response to lactic dehydrogenase isoenzymes. Cold Spr. Harb. Symp. quant. Biol. 32, 547–554 (1967).

    CAS  Google Scholar 

  • Rajewsky, K., Rottlánder, E., Petre, G., Müller, B.: The immune response to a hybrid protein molecule: specificity of secondary stimulation and of tolerance induction. J. exp. Med. 126, 581–606 (1967).

    PubMed  CAS  Google Scholar 

  • Rajewsky, K., Schirrmacher, V., Nase, S., Jerne, N. K.: The requirement of more than one antigenic determinant for immunogenicity. J. exp. Med. 129, 1131–1143 (1969).

    PubMed  CAS  Google Scholar 

  • Rhodes, J. M., Lind, I.: Antigen uptake in vivo by peritoneal macrophages from mice exhibiting antigenic competition. Immunology 20, 839–842 (1971).

    PubMed  CAS  Google Scholar 

  • Rittenberg, M. B., Amkraut, A.: Immunogenicity of trinitrophenylhemocyanin: production of primary and secondary anti-hapten precipitins. J. Immunol. 97, 421–430 (1966).

    PubMed  CAS  Google Scholar 

  • Roelants, G. E., Goodman, J. W.: Tolerance induction by an apparently non-immunogenic molecule. Nature (Lond.) 227, 175–176 (1970).

    CAS  Google Scholar 

  • Salaman, M. H., Wedderburn, N.: The immunodepressive effect of Friend virus. Immunology 10, 445–458 (1966).

    Google Scholar 

  • Salvin, S. B., Smith, R. F.: Specificity of allergic reactions. II. Azoproteins in the anamnestic response. Proc. Soc. exp. Biol. (N.Y.) 104, 584–590 (1960).

    CAS  Google Scholar 

  • Schechter, I.: Antigenic competition between polypeptidyl determinants in normal and tolerant rabbits. J. exp. Med. 127, 237–250 (1968).

    PubMed  CAS  Google Scholar 

  • Schechter, I., Sela, M.: Preferential formation of antibodies specific toward D-amino acid residues upon immunisation with poly-DL-peptidyl proteins. Biochemistry 6, 897–905 (1967).

    PubMed  CAS  Google Scholar 

  • Schwartz, H., Leskowitz, S.: Antigenic competition in the development of delayed hypersensitivity to the azobenzenearsonate group. Immunochemistry 6, 503–606 (1969).

    PubMed  CAS  Google Scholar 

  • Schwartz, R. S.: Immunoregulation by antibody. In: Amos, D. B. (ed.), Progr. Immunol. 1, 1082–1092 (1971).

    Google Scholar 

  • M. J. Taussig: Antigenic Competition Sela, M.: Molecular aspects of antigenicity. Science 166, 1365–1374 (1969).

    Google Scholar 

  • Sela, M., Fuchs, S., Arnon, R.: Studies on the chemical basis of the antigenicity of proteins. Y. Synthesis, characterisation and immunogenicity of some multichain and linear polypeptides containing tyrosine. Biochem. J. 85, 223–235 (1962).

    PubMed  CAS  Google Scholar 

  • Shearer, G. M., Mozes, E., Sela, M.: Cellular basis of the genetic control of immune responses to synthetic polypeptides. II. Frequency of immunocompetent precursors specific for two distinct regions within (Phe, G)-Pro-L, a synthetic polypeptide derived from multichain polyproline, in inbred mouse strains. J. exp. Med. 133, 216–230 (1971a).

    PubMed  CAS  Google Scholar 

  • Shearer, G. M., Mozes, E., Sela, M.: Cellular basis of the genetic control of immune responses. In: Amos, D. B. (ed.), Progress in immunology, vol. 1, p. 509–529. New York: Academic Press 1971b.

    Google Scholar 

  • Shearer, G. M., Mozes, E., Sela, M.: Contribution of different cell types to the genetic control of immune responses as a function of the chemical nature of the polymeric side chains (poly-L-prolyl and poly-DL-alanyl) of synthetic immunogens. J. exp. Med. 135 (1972). In Press.

    Google Scholar 

  • Siegel, B. Y., Morton, J. I.: Depressed antibody response in the mouse infected with Rauscher leukaemia virus. Immunology 10, 559–562 (1966).

    PubMed  CAS  Google Scholar 

  • Simonsen, M.: The clonal selection hypothesis evaluated by grafted cells reacting against their hosts. Cold Spr. Harb. Symp. quant. Biol. 32, 517–523 (1967).

    CAS  Google Scholar 

  • Siskind, G. W., Benacerraf, B.: Cell selection by antigen in the immune response. Advanc. Immunol. 10, 1–50 (1969).

    CAS  Google Scholar 

  • Smith, G. P., Hood, L., Fitch, W. M.: Antibody diversity. Ann. Rev. Biochem. 40, 969–1012 (1971).

    CAS  Google Scholar 

  • Smith, R. T., Landy, M. (eds.): Immune surveillance. New York-London: Academic Press 1970.

    Google Scholar 

  • Talmage, D. W., Radovich, J., Hemmingsen, H.: Cell interaction in antibody synthesis. Advanc. Immunol. 12, 271–282 (1970).

    CAS  Google Scholar 

  • Tarrab, R., Schechter, I., Sela, M.: Antibody response to polyalanyl determinants in tolerant rabbits. Immunochemistry 8, 1107–1116 (1971).

    PubMed  CAS  Google Scholar 

  • Taussig, M. J.: Bacteriophage linked assays for antibodies to protein antigens. Immunology 18, 323–330 (1970).

    PubMed  CAS  Google Scholar 

  • Taussig, M. J.: Studies on antigenic competition. I. Antigenic competition between the Fc and Fab fragments of rabbit I in mice. Immunology 21, 51–60 (1971).

    PubMed  CAS  Google Scholar 

  • Taussig, M. J.: Studies on antigenic competition. III. Is there a competitive step in tolerance induction? Europ. J. Immunol. 2, 118–123 (1972).

    CAS  Google Scholar 

  • Taussig, M. J., Lachmann, P. J.: Studies on antigenic competition. II. Abolition of antigenic competition by antibody against or tolerance to the dominant antigen: a model for antigenic competition. Immunology 22, 185–197 (1972).

    PubMed  CAS  Google Scholar 

  • Taussig, M. J., Mozes, E., Shearer, G. M., Sela, M.: Studies on the mechanism of antigenic competition. Analysis of competition between synthetic polypeptide antigens in mice. Europ. J. Immunol. (1972a) (in press).

    Google Scholar 

  • Taussig, M. J., Mozes, E., Shearer, G. M., Sela, M.: Genetic control of the immune response and antigenic competition. Cell. Immunol. (1972b) (in Press).

    Google Scholar 

  • Taussig, M. J., Mozes, E., Shearer, G. M., Sela, M.: Cooperation of antigenic determinants in vivo: interference by antigenic competition. Europ. J. Immunol. (1972c) (in Press).

    Google Scholar 

  • Taylor, R. B., Iverson, G. M.: Hapten competition and the nature of cell-cooperation in the antibody response. Proc. roy. Soc. B 176, 393–418 (1971).

    CAS  Google Scholar 

  • Uhr, J. W., Baumann, J. B.: Antibody formation. I. The suppression of antibody formation by passively administered antibody. J. exp. Med. 113, 935–958 (1961).

    PubMed  CAS  Google Scholar 

  • Veit, B. C., Michael, J. G.: Immune response suppression by an inhibitor in normal and immune mouse serum. Nature (Lond.) New Biol. 235, 238–240 (1972).

    CAS  Google Scholar 

  • Waterston, R. H.: Antigen competition: a paradox. Science 170, 1108–1109 (1970).

    PubMed  CAS  Google Scholar 

  • Weigle, W. O., High, G. J.: The effect of antigenic competition on antibody production to heterologous proteins, termination of immunologic unresponsiveness and induction of autoimmunity. J. Immunol. 99, 392–398 (1967).

    PubMed  CAS  Google Scholar 

  • Zlatogoroff, S. J., Glusman, M. P., Kandyba, L. L.: Experimentelle Untersuchungen iiber gleichzeitige Immunisierung gegen verschiedene Infektionen. Z. Hyg. Infekt.-Kr. 110, 706 (1929).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

    Michael J. Taussig

Authors
  1. Michael J. Taussig
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Basle, Switzerland

    W. Arber  & N. K. Jerne  & 

  2. New Brunswick, Canada

    W. Braun

  3. Freiburg, Germany

    R. Haas

  4. Philadelphia, USA

    W. Henle , P. Koldovský  & H. Koprowski ,  & 

  5. Munich, Germany

    P. H. Hofschneider

  6. Copenhagen, Denmark

    O. Maaløe

  7. Gießen, Germany

    R. Rott

  8. Wilhelmshaven, Germany

    H. G. Schweiger

  9. Rehovot, Israel

    M. Sela

  10. Prague, Czech Republic

    L. Syruček

  11. Seattle, USA

    P. K. Vogt

  12. Würzburg, Germany

    E. Wecker

Rights and permissions

Reprints and permissions

Copyright information

© 1973 Springer-Verlag, Berlin • Heidelberg

About this paper

Cite this paper

Taussig, M.J. (1973). Antigenic Competition. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 60. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65502-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-65502-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65504-3

  • Online ISBN: 978-3-642-65502-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation