Brain Tissue Pressure

  • W. Pöll
  • M. Brock
  • E. Markakis
  • W. Winkelmüller
  • H. Dietz

Abstract

The changes in regional cerebral blood flow observed in diseased areas of the brain when arterial PCO2 and/or arterial blood pressure are altered have been attributed to variations in local tissue perfusion pressure (TPP) [1] and to pressure gradients within the brain [2, 3, 4]. Conclusions drawn from “cerebral” perfusion pressure (CPP) calculations appear to possess only a restricted value for the analysis of local circulatory phenomena since CPP is an overall value. Local brain tissue perfusion pressure, however, can only be determined if the blood pressure within the small intraparenchymatous brain vessels and the “interstitial” pressure of the brain tissue are known. While recent papers [5, 6] contain quantitative data on blood pressure in small vessels of the brain, no satisfactory method has hitherto permitted the measurement of brain tissue pressure. Implantable capsules [7] and balloons filled with saline [8] are inappropriate for this purpose since they involve excessive damage to the brain tissue.

Keywords

Catheter Ischemia Polyethylene Heparin Respiration 

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References

  1. 1.
    Brock, M., Hadjidimos, A. A., Deruaz, J. P., Fischer, F., Dietz, H., Kohlmeyer, K., Pöll, W., Schürmann, K.: The effects of hyperventilation on regional cerebral blood flow. On the role of changes in intracranial pressure and tissue-perfusion pressure for shifts in rCBF distribution. In: Toole, J. F., Moossy, J., Janeway, R. (Eds.): Cerebral Vascular Diseases, p. 114–123. New York: Grune & Stratton 1971.Google Scholar
  2. 2.
    Brock, M.: Cerebral blood flow and intracranial pressure changes associated with brain hypoxia. In: Brierley, J. B., Meldrum, B. S. (Eds.): Brain Hypoxia, p. 14–18. Philadelphia: J. B. Lippincott Co. 1971.Google Scholar
  3. 3.
    Brock, M., Markakis, E., Beck, J., Dietz, H.: Intracranial pressure gradients associated with cerebrovascular occlusion. Lancet, II, 824 (1971).CrossRefGoogle Scholar
  4. 4.
    Brock, M., Beck, J., Markakis, E., Dietz, H.: Intracranial pressure gradients associated with experimental cerebral embolism. Stroke, 3, 123–130 (1972).PubMedCrossRefGoogle Scholar
  5. 5.
    Kanzow, E., Dieckhoff, D.: On the location of the vascular resistance in the cerebral circulation. In: Brock, M., Fieschi, C., Ingvar, D., Lassen, N., Schürmann, K. (Eds.): Cerebral Blood Flow, p. 96–97. Berlin-Heidelberg-New York: Springer 1969.Google Scholar
  6. 6.
    Shapiro, H. M., Stromberg, D. D., Lee, D. R., Wiederhielm, C. A.: Dynamic pressures in the pial arterial microcirculation. Amer. J. Physiol. 221, 279–283 (1971).Google Scholar
  7. 7.
    Guyton, A. C.: A concept of negative interstitial pressure based on pressures in implanted perforated capsules. Circulat. Res. 12, 399–414 (1963).Google Scholar
  8. 8.
    Weinstein, J. D., Langfitt, T. W., Bruno, L., Zaren, H. A., Jackson, J. L. F.: Experimental study of patterns of brain distortion and ischemia produced by an intracranial mass. J. Neurosurg. 28, 513–521 (1968).PubMedCrossRefGoogle Scholar
  9. 9.
    Scholander, P. F., Hargens, A. R., Miller, S. L.: Negative pressure in the interstitial fluid of animals. Science 161, 321–328 (1968).PubMedCrossRefGoogle Scholar
  10. 10.
    Strømme, S. B., Maggert, J. E., Scholander, P. F.: Interstitial fluid pressure in terrestrial and semiterrestrial animals. J. appl. Physiol. 27, 123–126 (1969).PubMedGoogle Scholar
  11. 11.
    Snashal, P. D., Lucas, J., Guz, A., Floyer, M. A.: Measurement of interstitial ‘fluid’ pressure by means of a cotton wick in man and animals: an analysis of the origin of the pressure. Clin. Sci. 41, 35–53 (1971).Google Scholar
  12. 12.
    Ladegaard-Pedersen, H. J.: Measurement of the interstitial pressure in subcutaneous tissue in dogs. Circulat. Res. 26, 765–770 (1970).Google Scholar
  13. 13.
    Brock, M., Winkelmüller, W., Pöll, W., Markakis, E., Dietz, H.: Measurement of brain-tissue pressure. Lancet, II, 595–596 (1972).CrossRefGoogle Scholar
  14. 14.
    Reinoso-Suarez, F.: Topographischer Hirnatlas der Katze. Darmstadt 1961.Google Scholar
  15. 15.
    Guyton, A. C.: Personal communication to M. B. in 1970.Google Scholar
  16. 16.
    Brock, M., Markakis, E., Pöll, W., Dietz, H.: In preparation.Google Scholar

Copyright information

© Springer-Verlag Berlin 1972

Authors and Affiliations

  • W. Pöll
  • M. Brock
  • E. Markakis
  • W. Winkelmüller
  • H. Dietz

There are no affiliations available

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