An Example of “Quasi-Irreversible” Protein-Protein Interaction: The Trypsin-Pancreatic Trypsin Inhibitor Complex

  • M. Lazdunski
  • J. P. Vincent
Part of the Colloquium der Gesellschaft für Biologische Chemie 13.–15. April 1972 in Mosbach/Baden book series (MOSBACH, volume 23)

Abstract

Each of the partners in the trypsin-PTI1 complex is well characterized. Both their covalent and their three-dimensional structures in the crystalline state are available (Walsh and Neurath, 1964; Stroud et al., 1971; Kassell and Laskowski, Sen., 1965; Chauvet et al., 1964; Anderer and Hörnle, 1966; Huber et al., 1970) and a considerable amount of work has been devoted to the analysis of the components of their active sites. Therefore, the trypsin-PTI complex appears to be an excellent model of heterologous protein-protein associations.

Keywords

Lipase Carboxylate Serine Lysine Polypeptide 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • M. Lazdunski
    • 1
  • J. P. Vincent
    • 1
  1. 1.Centre de Biologie Moléculaire du Centre National de la Recherche ScientifiqueMarseilleFrance

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