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An Example of “Quasi-Irreversible” Protein-Protein Interaction: The Trypsin-Pancreatic Trypsin Inhibitor Complex

  • M. Lazdunski
  • J. P. Vincent
Part of the Colloquium der Gesellschaft für Biologische Chemie 13.–15. April 1972 in Mosbach/Baden book series (MOSBACH, volume 23)

Abstract

Each of the partners in the trypsin-PTI1 complex is well characterized. Both their covalent and their three-dimensional structures in the crystalline state are available (Walsh and Neurath, 1964; Stroud et al., 1971; Kassell and Laskowski, Sen., 1965; Chauvet et al., 1964; Anderer and Hörnle, 1966; Huber et al., 1970) and a considerable amount of work has been devoted to the analysis of the components of their active sites. Therefore, the trypsin-PTI complex appears to be an excellent model of heterologous protein-protein associations.

Keywords

Disulfide Bond Dissociation Constant Trypsin Inhibitor Disulfide Bridge Iodoacetic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • M. Lazdunski
    • 1
  • J. P. Vincent
    • 1
  1. 1.Centre de Biologie Moléculaire du Centre National de la Recherche ScientifiqueMarseilleFrance

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