Abstract
Tobacco mosaic virus (TMV) is a rod-shaped virus consisting of a single-stranded RNA molecule embedded in a helical groove between adjacent turns of the helically aggregated protein [for detailed reviews see Caspar, 1963 and Lauffer and Stevens, 1968]. The isolated RNA has been shown to be infective [Gierer and Schramm, 1956; Fraenkel-Conrat, 1956], but it is very susceptible to attack by nucleases and so is unstable on its own. However, the protein and the RNA have been shown to reassemble to give an infective particle which is indistinguishable from the virus, and in which the RNA is protected and very stable [Fraenkel-Conrat and Williams, 1955]. It is thus of interest to understand the nature and control of the protein association in view of the knowledge this may give of the self-assembly into the intact virus.
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Butler, P.J.G. (1972). TMV Protein Association and its Role in the Self-Assembly of the Virus. In: Jaenicke, R., Helmreich, E. (eds) Protein-Protein Interactions. Colloquium der Gesellschaft für Biologische Chemie 13.–15. April 1972 in Mosbach/Baden, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65456-5_20
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DOI: https://doi.org/10.1007/978-3-642-65456-5_20
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