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Some Aspects of the Pharmacology of Adrenal Steroids and the Central Nervous System

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Steroids and Brain Edema

Abstract

The pharmacology and biochemistry of adrenal steroids as they relate to the central nervous system (CNS) have been extensively reviewed by Woodbury [76, 77]. In order to reduce redundancy, the present review has been limited to aspects of steroid pharmacology pertinent to their use in the therapy of brain edema. First, the uptake, distribution, exit and metabolism of glucorticoids have been discussed in detail. Second, the effects of both glucocorticoids and mineralocorticoids on CNS electrolyte metabolism in normal and pathological states have been summarized.

Supported by a United States Public Health Service Program-Project Grant (5-PO1-NS-04553) from the National Institute of Neurological Diseases and Stroke, National Institutes of Health.

Recipient of a USPHS Research Career Program Award (5-K6-NS-13, 838) from the National Institute of Neurological Diseases and Stroke, National Institutes of Health.

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Authors and Affiliations

  1. Department of Pharmacology, College of Medicine, University of Utah, Salt Lake City, UT, 84112, USA

    C. D. Withrow & Dixon M. Woodbury

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  1. C. D. Withrow
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  2. Dixon M. Woodbury
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  1. Neurochirurgische Universitätsklinik Mainz, 6500, Mainz, Langenbeckstr. 1, W. Germany

    H. J. Reulen  & K. Schürmann  & 

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Withrow, C.D., Woodbury, D.M. (1972). Some Aspects of the Pharmacology of Adrenal Steroids and the Central Nervous System. In: Reulen, H.J., Schürmann, K. (eds) Steroids and Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65448-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-65448-0_5

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