Summary
The effects of hypertonic urea on the blood-brain barrier (BBB) were studied in rabbits perfused through the internal carotid artery. Hypertonic urea solution produced two groups of barrier damage. In the first group, damage was irreversible and was associated with brain edema and hyperemia. These animals had an increased uptake of glucose which could not be self-inhibited as determined by a double-tracer technique. The second group of animals had reversible or partially reversible BBB damage without edema or hyperemia. Glucose uptake was increased also in those animals but could be self-inhibited. These results suggest that when hypertonic urea produces reversible or partially reversible barrier damage it also stimulates brain uptake of glucose by facilitated diffusion.
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Spatz, M., Rap, Z.M., Rapoport, S.I., Klatzo, I. (1972). The Effects of Hypertonic Urea on the Blood-Brain Barrier and on the Glucose Transport in the Brain. In: Reulen, H.J., Schürmann, K. (eds) Steroids and Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65448-0_3
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DOI: https://doi.org/10.1007/978-3-642-65448-0_3
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