Evidence Regarding the Action of Steroids in Injured Spinal Cord
Dexamethasone (0.25 mg/kg/day) prevents the loss of potassium from the injured spinal cord which occurs in untreated animals between the third and sixth day and persists on the ninth day.
The level of potassium in the spinal cord on the sixth day after injury correlates with the functional state of the animal at the same time.
These results indicate that in spinal cord injury, as in cerebral trauma, the benefical effects of dexamethasone do not appear to be mediated through their action on edema. In both instances, functional intergrity appears better preserved in dexamthasone-treated animals while effects on edema are not particulary impressive
KeywordsDexamethasone Neurol Mannitol Lewin
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