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Evidence Regarding the Action of Steroids in Injured Spinal Cord

  • Robert R. Hansebout
  • Marcial G. Lewin
  • Hanna M. Pappius

Summary

  1. 1.

    Dexamethasone (0.25 mg/kg/day) prevents the loss of potassium from the injured spinal cord which occurs in untreated animals between the third and sixth day and persists on the ninth day.

     
  2. 2.

    The level of potassium in the spinal cord on the sixth day after injury correlates with the functional state of the animal at the same time.

     
  3. 3.

    These results indicate that in spinal cord injury, as in cerebral trauma, the benefical effects of dexamethasone do not appear to be mediated through their action on edema. In both instances, functional intergrity appears better preserved in dexamthasone-treated animals while effects on edema are not particulary impressive

     

Keywords

Spinal Cord Spinal Cord Injury Brain Edema Potassium Content Untreated Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ducker, T. B., Hamit, H. F.: Experimental treatments of acute spinal cord injury. J. Neurosurg. 30, 693–697 (1969).PubMedCrossRefGoogle Scholar
  2. 2.
    Lewin, M. G., Pappius, H. M., Hansebout, R. R.: Effect of steroids on edema associated with injury of spinal cord. In: Steroids and Brain Edema, pp. 101–112. Berlin-Heidelberg-New York: Springer 1972.Google Scholar
  3. 3.
    Long, D. M., Hartmann, J. F., French, L. A.: The response of experimental cerebral edema to glucosteroid administration. J. Neurosurg. 24, 843–854 (1966).PubMedCrossRefGoogle Scholar
  4. 4.
    Pappius, H. M., McCann, W. P.: Effect of steroids on cerebral edema in cats. Arch. Neurol. 20, 207–216 (1969).PubMedGoogle Scholar
  5. 5.
    Richardson, H. D., Nakamura, S.: An electron microscopic study of spinal cord edema and the effect of treatment with steroids, mannitol and hypothermia. Proceedings of the American Association of Neurological Surgeons, Paper 39, 1971.Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • Robert R. Hansebout
    • 1
  • Marcial G. Lewin
    • 1
  • Hanna M. Pappius
    • 1
  1. 1.Montreal Neurological InstituteMcGill UniversityMontrealCanada

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