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Effect of Dexamethasone on Triethyl Tin Induced Brain Edema and the Early Edema in Cerebral Ischemia

  • Barry A. Siegel
  • Rebecca K. Studer
  • E. James Potchen

Summary

The effects of dexamethasone were investigated in experimental brain edema induced by triethyl tin intoxication and cerebral microembolism. Large doses of steroid (1.25 mg/kg/day) significandy reduced brain water and sodium in triethyl tin poisoned rats. However, in experimental microembolism, steroids had no effect on mortality, severity of edema, brain electrolyte changes, or cerebral isotope spaces.

Keywords

Cerebral Infarction Brain Edema Cerebral Edema Ischemic Brain Injury Organotin Compound 
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References

  1. 1.
    Aldridge, W. N., Cremer, J. E.: The biochemistry of organo-tin compounds. Diethyltin dichloride and triethyltin sulphate. Biochem. J. 61, 406–418 (1955).PubMedGoogle Scholar
  2. 2.
    Aleu, F. P., Katzman, R., Terry, R. D.: Fine structure and electrolyte analyses of cerebral edema induced by alkyl tin intoxication. J. Neuropath, exp. Neurol. 22,403–413 (1963).CrossRefGoogle Scholar
  3. 3.
    Ames, A., III, Wright, R. L., Kowada, M. et al.: Cerebral ischemia. II. The no-reflow phenomenon. Amer. J. Path. 52, 437–453 (1968).PubMedGoogle Scholar
  4. 4.
    Bakay, L.: Morphological and chemical studies in cerebral edema: Triethyltin induced edema. J. neurol. Sci. 2, 52–67 (1965).PubMedCrossRefGoogle Scholar
  5. 5.
    Cantu, R. C, Ames, A., III.: Experimental prevention of cerebral vasculature obstruction produced by ischemia. J. Neurosurg. 30, 50–54 (1969).PubMedCrossRefGoogle Scholar
  6. 6.
    Chiang, J., Kowada, M., Ames, A., III, et al.: Cerebral ischemia. III. Vascular changes. Amer. J. Path. 52, 455–476 (1968).PubMedGoogle Scholar
  7. 7.
    Cremer, J. E.: The metabolism in vitro of tissue slices from rats given triethyltin compounds. Biochem. J. 67, 87–96 (1957).PubMedGoogle Scholar
  8. 8.
    Cremer, J. E.: Studies on brain cortex slices. The influence of various inhibitors on the retention of potassium ions and amino acids with glucose or pyrurate as substrate. Biochem. J. 104, 223–228 (1967).PubMedGoogle Scholar
  9. 9.
    Cremer, J. E.: Selective inhibition of glucose oxidation by triethyltin in rat brain in vivo. Biochem. J. 119, 95–102 (1970).PubMedGoogle Scholar
  10. 10.
    Dyken, M., White, P. T.: Evaluation of cortisone in the treatment of cerebral infarction. J. Amer. med. Ass. 162, 1531–1534 (1956).Google Scholar
  11. 11.
    Harnack, E.: Über die Wirkungen des Bleis auf den thierischen Organismus. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 9, 152–225 (1878).CrossRefGoogle Scholar
  12. 12.
    Joo, V. F., Zoltan, O. T., Csillik, B. et al.: Untersuchungen über das durch Triethylzinnsulfat verursachte Hirnoedem bei der Ratte. 5. Mitteilung: Die Wirkung von Triaethylzinnsulfat auf die Permeabilitat der Blut-Hirn-Schranke. Arzneimittel-Forsch. 19, 296–297 (1969).Google Scholar
  13. 13.
    Kahn, K., Pranzarone, G. F., Newman, T.: Dexamethasone treatment of experimental cerebral infarction (Abstract). Neurology 22, 406–407 (1972).Google Scholar
  14. 14.
    Kalsbeck, J. E., Cummings, J. N.: Experimental edema in the rat and cat brain. J. Neuropath, exp. Neurol. 22, 237–247 (1963).CrossRefGoogle Scholar
  15. 15.
    Katzman, R., Aleu, F., Wilson, C.: Further observations on triethyltin edema. Arch. Neurol. (Chic.) 9, 88–97 (1963).Google Scholar
  16. 16.
    Lee, J. C, Bakay, L.: Ultrastructural changes in the edematous central nervous system. 1. Triethyltin edema. Arch. Neurol. (Chic.) 13, 48–57 (1965).Google Scholar
  17. 17.
    Levy, A., Taylor, J. M., Herzog, I. et al.: The effect of hypertonic urea on cerebral edema in the rabbit induced by triethyl tin sulfate. Arch. Neurol. (Chic.) 13, 58–64 (1965).Google Scholar
  18. 18.
    Magee, P. N., Stoner, H. B., Barnes, J. M.: The experimental production of oedema in the central nervous system of the rat by triethyl tin compounds. J. Path. Bact. 73, 107–124 (1957).CrossRefGoogle Scholar
  19. 19.
    Maha, G. E.: Adrenal corticosteroid therapy of cerebral edema. Perm. Med. 73, 50–55 (1970).Google Scholar
  20. 20.
    Mandell, S., Taylor, J. M., Kotsilimbas, D. G. et al.: The effect of glycerol on cerebral edema induced by tri-ethyltin sulphate in rabbits. J. Neurosurg. 24, 984–986 (1966).PubMedCrossRefGoogle Scholar
  21. 21.
    Moore, K. E., Brody, T. M.: The effect of triethyltin on oxidative phosphorylation and mitochondrial adenosine triphosphatase activation. Biochem. Pharmacol. 6, 125–133 (1961).PubMedCrossRefGoogle Scholar
  22. 22.
    Ng. L. K. Y., Nimmannitya, J.: Massive cerebral infarction with brain swelling. A clinicopathological study. Stroke 1, 158–163 (1970).PubMedCrossRefGoogle Scholar
  23. 23.
    Pappius, H. M., McCann, W. P.: Effects of steroids on cerebral edema in cats. Arch. Neurol. (Chic.) 20, 207–216 (1969).Google Scholar
  24. 24.
    Patten, B. M., Mendell, J., Bruun, B. et al.: Double-blind study of the effects of dexamethasone on acute stroke. Neurology 22, 377–383 (1972).PubMedGoogle Scholar
  25. 25.
    Plum, F.: Brain swelling and edema in cerebral vascular disease. Proc. Ass. Res. nerv. ment. Dis. 41, 318–348 (1964).Google Scholar
  26. 26.
    Plum, F. Alvord, E. C, Jr., Posner, J. B.: Effect of steroids on experimental cerebral infarction. Arch. Neurol. (Chic.) 9, 571–573 (1963).Google Scholar
  27. 27.
    Potchen, E. J., Adatepe, M. H., Studer, R. et al.: Radioisotopic assessment of cerebral edema. Arch. Neurol. (Chic.) 24, 287–290 (1971).Google Scholar
  28. 28.
    Prados, M., Strowger, B., Feindel, W.: Studies on cerebral edema. II. Reaction of the brain to exposure to air: Physiologic changes. Arch. Neurol. Psychiat. (Chic.) 54, 290–300 (1945).Google Scholar
  29. 29.
    Reed, D. J., Woodbury, D. M., Holtzer, R. L.: Brain edema, electrolytes and extracellular space. Arch. Neurol. (Chic.) 10, 604–616 (1964).Google Scholar
  30. 30.
    Roberts, H. J.: Supportive adrenocortical steroid therapy in acute and subacute cerebrovascular accidents with particular reference to brain stem involvement. J. Amer. Geriat. Soc. 6, 686–702 (1952).Google Scholar
  31. 31.
    Rose, M. S., Aldridge, W. N.: The interaction of triethyltin with components of animal tissues. Biochem. J. 106, 821–828 (1968).PubMedGoogle Scholar
  32. 32.
    Rouzaud, M., Lutier, J.: Oedeme subaigu cerebro-meninge du a une intoxication d’actualite. Presse méd 62, 1075 (1954).PubMedGoogle Scholar
  33. 33.
    Rubinstein, M. K.: The influence of adrenocortical steroids on severe cerebrovascular accidents. J. nerv. ment. Dis. 141, 291–299 (1965).PubMedCrossRefGoogle Scholar
  34. 34.
    Russek, H. I., Russek, A. S. Zohman, B. L.: Cortisone in immediate therapy of apoplectic stroke. J. Amer. med. Ass. 159, 102–105 (1955).Google Scholar
  35. 35.
    Russell, R. W. R.: A study of the microcirculation in experimental cerebral embolism. Angiologica 3, 240–258 (1966).PubMedGoogle Scholar
  36. 36.
    Shaw, C. M., Alvord, E. C, Jr., Berry, R. G.: Swelling of the brain following ischemic infarction with arterial occlusion. Arch. Neurol. (Chic.) 1, 161–177 (1959).Google Scholar
  37. 37.
    Siegel, B. A., Meidinger, R., Elliott, A. J. et al.: Experimental cerebral microembolism: Multiple tracer assessment of brain edema. Arch. Neurol. (Chic.) 26, 73–77 (1972).Google Scholar
  38. 38.
    Siegel, B. A., Studer, R. K., Potchen, E. J.: Steroid therapy of brain edema: Ineffectiveness in experimental cerebral microembolism. Arch. Neurol. (Chic.) 27, 209–212 (1972).Google Scholar
  39. 39.
    Steegman, A. T., de la Fuente, J.: Experimental cerebral embolism: II. Microembolism of the rabbit brain with seran polymer resin. J. Neuropath, exp. Neurol. 18, 537–558 (1959).CrossRefGoogle Scholar
  40. 40.
    Stoner, H. B., Barnes, J. M., Duff, J. I.: Studies on the toxicity of alkyl tin compounds. Brit. J. Pharmacol. 10, 16–25 (1955).PubMedGoogle Scholar
  41. 41.
    Streicher, E.: Thethiocyanate space of rat brain in experimental cerebral edema. J. Neuropath, exp. Neurol. 21, 437–441 (1962).CrossRefGoogle Scholar
  42. 42.
    Studer, R., Potchen, E. J.: Effects of dexamethasone on triethyl tin induced brain edema in rats. (Abstract) Clin. Res. 19, 356 (1971).Google Scholar
  43. 43.
    Taylor, J. M., Levy, W. A., Herzog, I. et al.: Prevention of experimental cerebral edema by corticosteroids. Neurology 15, 667–614 (1965).PubMedGoogle Scholar
  44. 44.
    McCoy, G. et al.: Prevention of cerebral edema induced by triethyltin in rabbits by cortico-steroids. Nature 204, 891–892 (1964).PubMedCrossRefGoogle Scholar
  45. 45.
    Timiras, P. S., Woodbury, D. M., Goodman, L. S.: Effect of adrenalectomy, hydrocortisone acetate and desoxycorticosterone acetate on brain excitability and electrolyte distribution in mice. J. Pharmacol, exp. Ther. 112, 80–93 (1954).Google Scholar
  46. 46.
    Torack, R. M.: The relationship between adenosinetriphosphatase activity and triethyltin toxicity in the production of cerebral edema of the rat. Amer. J. Path. 46, 245–261 (1965).PubMedGoogle Scholar
  47. 47.
    Torack, R. M., Gordon, J., Prokop, J.: Pathobiology of acute triethyltin intoxication. Int. Rev. Neurobiol. 12, 45–86 (1970).PubMedCrossRefGoogle Scholar
  48. 48.
    Torack, R. M., Terry, R. D., Zimmerman, H. M.: The fine structure of cerebral fluid accumulation. II. Swelling produced by triethyl tin poisoning and its comparison with that in the human brain. Amer. J. Path. 36, 273–287 (1960).PubMedGoogle Scholar
  49. 49.
    Ungar, E., Bodlander, G.: Über die toxischen Wirkungen des Zinns, mit besonderer Berucksichtigung der durch den Gebrauch verzinnter Conservenbuchsen der Gesundheit drohenden Gefahren. Z. Hyg. Infek.-Kr. 2, 241–296 (1887).CrossRefGoogle Scholar
  50. 50.
    Van der Kerk, G. J. M., Luijten, J. G. A.: Organotin compounds. III. Biocidal properties of organotin compounds. J. appl. Chem. 4, 314–319 (1954).CrossRefGoogle Scholar
  51. 51.
    Varkonyi, V. T., Csillik, B., Zoltan, O. T. et al.: Untersuchungen uber das durch Triaethylzinnsulfat verursachte Hirnodem bei der Ratte. 4. Mitteilung: Elektronenoptische Untersuchungen. Arzneimittel-Forsch. 19, 293–295 (1969).Google Scholar
  52. 52.
    Varkonyi, V. T., Maurer, M., Zoltan, O. T. et al.: Untersuchungen über das durch Triaethylzinnsulfat verursachte Hirnodem bei der Ratte. 9. Mitteilung: Die Wirkung von Mannit auf das elektronenoptische Bild der experimentell durch Triaethylzinnsulfat hervorgerufenen Vergiftung bei der Ratte. Arzneimittel-Forsch. 21, 147–148 (1971).Google Scholar
  53. 54.
    Varkonyi, V. T., Maurer, M., Zoltan, O. T. et al.: Untersuchungen über das durch Triaethylzinnsulfat (TZS) verursachte Hirnodem bei der Ratte. 10. Mitteilung: Die Wirkung von Silymarin auf das elektronenoptische Bild der experimentell durch Triaethylzinnsulfat hervorgerufenen Vergiftung bei der Ratte. Arzneimittel-Forsch. 21, 148–149 (1971).Google Scholar
  54. 54.
    White, T. P.: Über die Wirkungen des Zinns auf den thierischen Organismus. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmakol. 13, 53–69 (1880–1881).CrossRefGoogle Scholar
  55. 55.
    Zulch, K. J.: Neuropathological aspects and histological criteria of brain edema and brain swelling. In: Klatzo, I., Seitelberger, F. (Eds.): Brain Edema, pp. 95–116. Berlin-Heidelberg-New York: Springer 1967.Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • Barry A. Siegel
    • 1
  • Rebecca K. Studer
    • 1
  • E. James Potchen
    • 1
  1. 1.The Edward Mallinckrodt Institute of Radiology, School of MedicineWashington UniversitySt. LouisUSA

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