Abstract
The ability of corticosteroids to alleviate symptoms, prolong life, and inhibit growth of tumors under both clinical and experimental conditions is well known [5, 13, 20, 29, 30]. Conversely, a complete lack of response and even enhancement of tumor growth have also been observed [18, 19, 36]. Corticosteroids have assumed a major role in the treatment of brain tumors based upon their effect in reducing related cerebral edema. The possible oncolytic properties of these drugs have received less emphasis, and most clinical reports dealing with prolonged corticosteroid therapy for intracranial tumors concern secondary, rather than primary tumors. The relief afforded is thought to be due to reduction of cerebral edema rather than a direct inhibitory effect upon the tumor. However, in cases of meningeal leukemia, clinical “cures” have been reported following the systemic administration of corticosteroids [31, 33].
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References
Arpels, C, Babcock, V. I., Southram, C. M.: Effect of steroids on human cell cultures; sustaining effect of hydrocortisone. Proc. Soc. exp. Biol. 115, 102–106 (1963).
Baserga, R., Schbik, P.: The action of cortisone on transplanted and induced tumors in mice. Cancer Res. 14, 12–16 (1954).
Baxter, J. P., Tomkins, G. M.: Glucocorticoid Hormone Receptors Advances in the Biosciences. Raspe, G. (Ed.). New York: Pergamon Press 1970.
Baxter, J. P., Tomkins, G. M.: Specific cytoplasmic glucocorticoid hormone receptors in hepatoma tissue culture cells. Proc. nat. Acad. Sci. 68, 932–937 (1971).
Blinderman, E. E., Graff, C. J., Fitzpatrick, T.: Basic studies in cerebral edema: Its control by a corticosteroid (Solu-Medrol). J. Neurosurg. 19, 319–324 (1962).
Bruce, W. R., Meeker, B. E., Valeriote, F. A.: Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo. J.Nat. Cancer Inst. 37, 233 (1966).
Bullough, W. S., Laurence, E. B.: The role of glucocorticoid hormones in the control of epidermal mitosis. Cell Tiss. Kinet. 1, 5 (1968).
Burton, A. F., Storr, J. M., Dunn, W. L.: Cytolytic action of corticosteroids on thymus and lymphoma cells in vitro. Canad. J.Biochem. 45, 289–297 (1967).
Connor, J. D., Marti, A.: Reversal of contact inhibition in primary arnmion cultures by hydrocortisone. Proc. Soc. exp. Biol. 123, 730–735 (1966).
Dell’Orco, R. T., Melnykovych, C.: Lipid composition of heteroploid cells in culture: Effects of prednisolone. J. cell. Physiol. 76, 101–106 (1970).
Foley, G. E., Lazarus, H.: The response in vitro of continuous cultures of human lymphoblasts (CCRF-CEM cells) to chemotherapeutic agents. Biochem. Pharmacol. 16, 659 (1967).
Gabourel, J. E., Arnow, L.: Growth inhibitory effects of hydrocortisone on mouse lymphoma ML-388 in vitro. J. Pharmacol, exp. Ther. 136, 213–221 (1962).
Grenell, R. G., McCawley, E. L.: Central nervous system resistance. II. The effect of adrenal cortical substances on the central nervous system. J. Neurosurg. 4, 508–518 (1947).
Gurcay, O., Wilson, C, Barker, M., Eliason, J.: Corticosteroid effect on transplantable rat glioma. Arch. Neurol. 24, 266 (1971).
Hydes, T. A., Davis, J. G.: The effects of corticortisol and chloranzanil on the mitotic rate in mouse liver and skin. Europ. J. Cancer 2, 227–230 (1966).
Kimberg, D. V., Loud, A. V., Wiener, J.: Cortisone-induced alterations in mitochondrial function and structure. J. Cell Biol. 37, 63–79 (1968).
Kline, I., Leighton, J., Belkin, M., Orr, H. C.: Some observations on the response of four established cell strains to hydrocortisone in tissue culture. Cancer Res. 17, 780–784 (1957).
Kodama, M.: Effect of hydrocortisone on Ehrlich ascites tumor. Cancer Res. 22, 1212–1219 (1962).
Kodama, M., Kodama, T.: Effect of steroid hormones on the in vivo incorporation of glycine-2-14C into solid Ehrlich tumor, kidney and liver. Cancer Res. 30, 228–235 (1970).
Kofman, S., Garvin, J. S., Nagamani, D., Taylor, S. G.: Treatment of cerebral metastasis from breast carcinoma with prednisolone. J. Amer. med. Ass. 163; 1473–1476 (1957).
Kollmorgen, G. M., Griffin, M. J.: The effect of hydrocortisone on HeLa cell growth. Cell Tiss. Kinet. 2, 111–112 (1969).
Kotsilimbas, D. G., Meyer, L., Berson, M., Taylor, J. M., Scheinberg, L. C: Corticosteroid effect on intracerebral melanomata and associated edema. Some unexpected findings. Neurology 17, 223–226 (1967).
Kupiecki, F. P.: Cell culture studies with unique cytotoxic steroids. Cancer Res. 25, 417–420 (1965).
Levinson, B. B., Baxter, J. D., Rousseau, G. G.: Cellular site of Glucocorticoid receptor complex formation. Science 175, 189–190 (1972).
Mealey, J., Ehen, T. T., Schanz, G. P.: The effects of dexamethasone and methylprednisolone on cell cultures of human glioblastoma. J. Neurosurg. 34, 324 (1971).
Melnykovych, H. G, Swayze, M. A., Bishop, C. F.: Effects of cultural condition on alkaline phosphatase and cell culture survival in the presence of prednisolone. Exp. Cell Res. 47, 167–176 (1967).
Omura, E. F., Schwartz, M. S., Jahiel, R. I. et al.: Effect of hydrocortisone on growth and detachment of human heteroploid cells in maintenance media. Proc. Soc. exp. Biol. 125, 447–451 (1967).
Pearson, O. H., Li, M. C, Maclean, J. P. et al.: The use of hydrocortisone in cancer. Ann. N. Y. Acad. Sci. 61, 393 (1955).
Prados, M., Stowger, B., Feindel, W. H.: Studies on cerebral edema: I. Reaction of the brain to air exposure; pathologic changes. Arch. Neurol. Psychiat. 54, 163–174 (1945).
Rasmussen, T., Gulati, D. R.: Cortisone in the treatment of postoperative cerebral edema. J. Neurosurg. 19, 535–544 (1962).
Ruderman, N. B., Hall, T. C: Use of glucocorticoids in the palliative treatment of metastatic brain tumors. Cancer 18, 298–306 (1965).
Schafer, I. A., McManus, T. J., Sullivan, J. C. et al.: Inhibition by hydrocortisone of iododeoxyuridine incorporation into the DNA of cultured mammalian cells. Exp. Cell Res. 44, 108–118 (1966).
Shaw, R. K., Moore, E. W., Freireich, E. J., Thomas, L. B.: Meningeal Leukemia. Neurology (Minneap.) 10, 823–833 (1960).
Simpson-Herren, L., Lloyd, H. H.: Kinetic parameters and growth curves for experimental tumors systems. Cancer Chemother. Rep. 54, 143–174 (1970).
Stock, C. C, Karnofsky, D. A., Sugiura, K.: Studies on steroids for inhibition of normal and abnormal growth in experimental animals. In: White, A. (Ed.): Symposium on Steroids in Experimental and Clinical Practice. Philadelphia: Blakiston Co. 1951.
Toolan, H. W.: Growth of human tumors in cortisone-treated laboratory animals: The possibility of obtaining permanently transplantable human tumors. Cancer Res. 13, 389–394 (1953).
Weinger, E., Marmary, Y.: The in vitro effect of hydrocortisone on cultures of peritoneal monocytes. Lab. Invest. 21, 525–511 (1969).
Wellings, S. R., Moon, H. D.: Morphologic and functional effects of hydrocortisone in tissue culture. Lab. Invest. 10, 539–547 (1961).
Wellington, J. S., Moon, H. D.: Effect of hydrocortisone on human cells in tissue culture. Proc Soc. exp. Biol. 107, 556–559 (1961).
Wright, R. L., Shaumba, B., Xeller, J.: The effect of glucocorticosteroids on growth and metabolism of experimental glial tumors. J. Neurosurg. 30,140–145 (1969).
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Wilson, C.B., Barker, M., Hoshino, T., Oliver, A., Downie, R. (1972). Steroid-Induced Inhibition of Growth in Glial Tumors: a Kinetic Analysis. In: Reulen, H.J., Schürmann, K. (eds) Steroids and Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65448-0_10
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