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Current Topics in Microbiology and Immunology pp 167–200Cite as

Genetic Control of Immune Responses

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 59))

Abstract

The observation that inheritance can influence immune reactions was made more than half a century ago. Cooke and van der Veer (1916) found that inheritance plays a significant role in the development of hay fever, bronchial asthma, gastro-enteritis, and other forms of human sensitization. They concluded that this phenomenon is genetically transmitted from parent to offspring as a dominant characteristic, and that it does not involve the transmission of sensitization itself. It was not until several decades later that the genetic controls of antibody responses to diphtheria toxoid (Scheibel, 1943), to pneumococcal polysaccharide (Fink and Quinn, 1953), and to insulin (Arquilla and Finn, 1963, 1965) were discovered. This has been followed in recent years by a deluge of isolated and interrelated reports of genetic control of immune response for many immunogens in at least four species. Nevertheless, the most significant recent progress made in elucidation of this very complex and intriguing genetically-determined phenomenon can be attributed to advance made in three independent scientific areas.

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Author information

Authors and Affiliations

  1. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

    G. M. Shearer

Authors
  1. Edna Mozes
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  2. G. M. Shearer
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Editor information

Editors and Affiliations

  1. Basle, Switzerland

    W. Arber  & N. K. Jerne  & 

  2. New Brunswick, USA

    W. Braun

  3. Freiburg, Germany

    R. Haas

  4. Philadelphia, USA

    W. Henle , P. Koldovský  & H. Koprowski ,  & 

  5. Munich, Germany

    P. H. Hofschneider

  6. Copenhagen, Denmark

    O. Maaløe

  7. Gießen, Germany

    R. Rott

  8. Wilhelmshaven, Germany

    H. G. Schweiger

  9. Rehovot, Israel

    M. Sela

  10. Prague, Czech Republic

    L. Svruček

  11. Los Angeles, USA

    P. K. Vogt

  12. Würzburg, Germany

    E. Wecker

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© 1972 Springer-Verlag, Berlin Heidelberg

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Mozes, E., Shearer, G.M. (1972). Genetic Control of Immune Responses. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65444-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-65444-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65446-6

  • Online ISBN: 978-3-642-65444-2

  • eBook Packages: Springer Book Archive

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