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On the Origin of Pandemic Influenza Viruses

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 59))

Abstract

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (Beveridge, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve changes in the hemagglutinin and neuraminidase antigens on the surface of the virus.

This work was supported by Research Grant AI-08831 from the National Institute of Allergy and Infectious Diseases, General Research Grant RR-05584 from the National Institute of Health, Childhood Cancer Research Center Grant CA-08480 from the National Cancer Institute, and by ALSAC.

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References

  • Ada, G. L., Perry, B. T.: The nucleic acid content of influenza virus. Aust. J. exp. Biol. med. Sci. 32 , 453–468 (1954).

    PubMed  CAS  Google Scholar 

  • Almeida, J. D., Waterson, A. P.: Two morphological aspects of influenza virus. In: The biology of large RNA viruses, p. 27–51 (R. D.Barry and B. W. J.Mahy, eds.). New York: Academic Press 4970.

    Google Scholar 

  • Apostolov, K., Flewett, T. H.: Internal structure of influenza virus. Virology 26 , 506–508 (1965).

    PubMed  CAS  Google Scholar 

  • Archetti, I., Horsfall, F. L., Jr.: Persistent antigenic variation of influenza A viruses after incomplete neutralization in ovo with heterologous immune serum. J. exp. Med. 92, 441–462 (1950).

    PubMed  CAS  Google Scholar 

  • Bancroft, J. B.: A virus made from parts of the genomes of brome mosaic and cowpea chlorotic mottle viruses. J. gen. Virol. 14, 223–228 (1972).

    Google Scholar 

  • Barry, R. D.: The multiplication of influenza virus. II. Multiplicity reactivation of ultraviolet irradiated virus. Virology 14, 398 – 405 (1961).

    PubMed  CAS  Google Scholar 

  • Becht, H., Hammerling, U.,Rott, R.: Undisturbed release of influenza virus in the presence of univalent antineuraminidase antibodies. Virology 46 , 337–343 (1971).

    CAS  Google Scholar 

  • Beveridge, W. I. B.: Taming the last great plague. Information service of the British High Commission (4th August) 1969.

    Google Scholar 

  • Bishop, D. H. L., Obijeski, J. F., Simpson, R.W.: Transcription of the influenza ribonucleic acid genome by a virion polymerase. 1. Optimal conditions for in vitro activity of the ribonucleic acid-dependent ribonucleic acid polymerase. J. Virol. 8, 66–73 (1971a).

    PubMed  CAS  Google Scholar 

  • Bishop, D. H. L., Obijeski, J. F., Simpson, R. W.: Transcription of the influenza ribonucleic acid genome by a virion polymerase. II. Nature of the in vitro polymerase product. J. Virol. 8, 74–80 (1971b).

    PubMed  CAS  Google Scholar 

  • Blair, C. D., Duesberg, P. H.: Myxovirus ribonucleic acids. Ann. Rev. Microbiol. 24, 539–574 (1970).

    CAS  Google Scholar 

  • Blough, H. A., Tiffany, J. M.: Incorporation of branched-chain fatty acid into myxoviruses. Proc. nat. Acad. Sci. (Wash.) 62, 242–247 (1969).

    CAS  Google Scholar 

  • Burnet, F. M.: Structure of influenza virus. Science 123, 1101–1104 (1956).

    PubMed  CAS  Google Scholar 

  • Burnet, F. M., Lind, P. E.: Recombination of characters between two influenza virus strains. Aust. J. Sci. 12, 109–110 (1949).

    Google Scholar 

  • Burnet, F. M., Lind, P. E.: A genetic approach to variation in influenza viruses. (4) Recombination of characters between the influenza virus A strain NWS and strains of different serological subtypes. J. gen. Microbiol. 5, 67–82 (1951).

    PubMed  CAS  Google Scholar 

  • Choppin, P. W., Pons, M. W.: The RNAs of infective and incomplete influenza virions grown in MDBK and HeLa cells. Virology 42, 603–610 (1970).

    PubMed  CAS  Google Scholar 

  • Chow, N. L., Simpson, R. W.: RNA-dependent RNA polymerase activity associated with virions and subviral particles of myxoviruses. Proc. nat. Acad. Sci. (Wash.) 68, 752–756 (1971).

    CAS  Google Scholar 

  • Coleman, M. T., Dowdle, W. R., Pereira, H. G., Schild, G. C., Chang, W. K.: The Hong Kong/68 influenza A2 variant. Lancet 1968II, 1384–1386.

    Google Scholar 

  • Compans, R. W., Dimmock, N. J.: An electron microscopic study of single-cycle infection of chick embryo fibroblasts by influenza virus. Virology 39, 499–515 (1969).

    PubMed  CAS  Google Scholar 

  • Compans, R. W., Dimmock, N. J., Meier-Ewert, H.: An electron microscopic study of the influenza virus-infected cell. In: The biology of large RNA viruses, p. 87–108 ( R. D. Barry and B. W. J. Mahy, eds.). New York: Academic Press 1970b.

    Google Scholar 

  • Compans, R. W., Klenk, H. D., Caliguiri, L. A., Choppin, P. W.: Influenza virus proteins. 1. Analysis of polypeptides of the virion and identification of spike glycoproteins. Virology 42, 880–889 (1970a).

    PubMed  CAS  Google Scholar 

  • Cooper, P. D.: A genetic map of poliovirus temperature–sensitive mutants. Virology 35, 584–596 (1968).

    PubMed  CAS  Google Scholar 

  • Dasen, C. A., Laver, W. G.: Antibodies to influenza viruses (including the human A2/Asian/57 strain) in sera from Australian shearwaters (Puffinus Pacificus). Bull. Wld Hlth Org. 42, 885–889 (1970).

    CAS  Google Scholar 

  • Davenport, F. M., Hennessy, A. V.: The clinical epidemiology of Asian influenza. Ann. intern. Med. 49, 493–501 (1958).

    PubMed  CAS  Google Scholar 

  • Davenport, F. M., Hennessy, A. V., Francis, T., JR.: Epidemiologic and immunologic significance of age distribution of antibody to antigenic variants of influenza virus. J. exp. Med. 98, 641–656 (1953).

    PubMed  CAS  Google Scholar 

  • Davenport, F. M., Hennessy, A. V., Minuse, E.: Further observations on the significance of A/Equine–2/63 antibodies in man. J. exp. Med. 126, 1049–1061 (1967).

    PubMed  CAS  Google Scholar 

  • Dimmock, N. J.: New virus–specific antigens in cells infected with influenza virus. Virology 39, 224–234 (1969).

    PubMed  CAS  Google Scholar 

  • Dimmock, N. J., Watson, D. H.: Proteins specified by influenza virus in infected cells: Analysis of polyacrylamide gel electrophoresis of antigens not present in the virus particle. J. gen. Virol. 5, 499–509 (1969).

    CAS  Google Scholar 

  • Dowdle, W. R., Coleman, M. T., Hall, E. C., Knez, V.: Properties of the Hong Kong influenza virus. 2. Antigenic relationship of the Hong Kong virus hemagglutinin to that of other human influenza A viruses. Bull. Wld Hlth Org. 41, 419–424 (1969).

    CAS  Google Scholar 

  • Dowdle, W. R., Marine, W. M., Coleman, M. T., Knez, V.: Proceedings 2nd International Congress for Virology (Budapest), ed. J. Melnick. (In press, 1972.)

    Google Scholar 

  • Duesberg, P. H.: The RNAs of influenza virus. Proc. nat. Acad. Sci. (Wash.) 59, 930–937 (1968).

    CAS  Google Scholar 

  • Duesberg, P. H.: Distinct subunits of the ribonucleoprotein of influenza virus. J. molec. Biol. 42, 485–499 (1969).

    PubMed  CAS  Google Scholar 

  • Easterday, B., Laver, W. G., Pereira, H. G., Schild, G. C.: Antigenic composition of recombinant virus strains produced from human and avian influenza A viruses. J. gen. Virol. 5, 83–91 (1969).

    PubMed  CAS  Google Scholar 

  • Easterday, B.C., Tumova, B.: Avian influenza viruses: In avian species and the natural history of influenza. Advanc. vet. Sci. com. Med. 16 (In press, 1972).

    Google Scholar 

  • Fazekas de ST. Groth, S.: New criteria for the selection of influenza vaccine strains. Bull. Wld Hlth Org. 41, 651–657 (1969).

    Google Scholar 

  • Fazekas de St. Groth, S.: Evolution and hierarchy of influenza viruses. Arch, environm. Hlth 21, 293–303 (1970).

    Google Scholar 

  • Francis, T., Jr., Maassab, H. F.: Influenza viruses: In: Viral and rickettsial infections of man, 4th ed., p. 689–740 (Horsfall and Tamm, eds.). Philadelphia: Lippincott 1965.

    Google Scholar 

  • Granoff, A.: Studies on mixed infection with Newcastle disease virus. I. Isolation of Newcastle disease virus mutants and tests for genetic recombination between them. Virology 9, 636–648 (1959).

    PubMed  CAS  Google Scholar 

  • Hamre, D., Loosli, C. G., Gerber, P.: Antigenic variants of influenza A virus (PR 8 strain). III. Serological relationships of a line of variants derived in sequence in mice given homologous vaccine. J. exp. Med. 107, 829–844 (1958).

    PubMed  CAS  Google Scholar 

  • Haslam, E. A., Hampson, A. W., Radiskevics, I., White, D. O.: The polypeptides of influenza virus. III. Identification of the hemagglutinin, neuraminidase and nucleo- capsid proteins. Virology 42, 566–575 (1970).

    PubMed  CAS  Google Scholar 

  • Hilleman, M. R., Flatley, F. J., Anderson, S. A., Luecking, M. L., Levinson, D. J.: Distribution and significance of Asian and other influenza antibodies in the human population. New Engl. J. Med. 258, 969–974 (1958).

    CAS  Google Scholar 

  • Hirst, G. K.: Genetic recombination with Newcastle disease virus, polioviruses, and influenza. Cold Spr. Harb. Symp. quant. Biol. 27, 303–309 (1962).

    CAS  Google Scholar 

  • Hirst, G. K., Gotlieb, T.: The experimental production of combination forms of virus. V. Alterations in the virulence of neurotrophic influenza virus as a result of mixed infection. Virology 1, 221–235 (1955).

    PubMed  CAS  Google Scholar 

  • Isaacs, A., Edney, M.: Variation in laboratory stocks of influenza viruses: Genetic aspects of variations. Brit. J. exp. Path. 31, 209–216 (1950).

    PubMed  CAS  Google Scholar 

  • Johnsen, D. O., Wooding, W. L., Tanticharoenyos, P., Karnjanaprakorn, C.: An epizootic of A2/Hong Kong/68 influenza in gibbons. J. infect. Dis. 123, 365–370 (1971).

    PubMed  CAS  Google Scholar 

  • Kalter, S. S., Heberling, R. L., Vice, T. E., Lief, F. S., Rodriguez, A. R.: Influenza (A2/Hong Kong/68) in the baboon (Papio sp.). Proc. Soc. exp. Biol. (N.Y.) 132, 357–361 (1969).

    CAS  Google Scholar 

  • Kaplan, M. M., Payne, A. M. M.: Serological survey in animals for Type A influenza in relation to the 1957 pandemic. Bull. Wld Hlth Org. 20, 465–488 (1959).

    CAS  Google Scholar 

  • Kasel, J. A., Alford, R. H., Knight, V., Waddell, G. H., Sigel, M. M.: Experimental infection of human volunteers with equine influenza virus. Nature (Lond.) 206, 41–43 (1965).

    CAS  Google Scholar 

  • Kasel, J. A., Couch, R. B.: Experimental infection in man and horses with influenza A viruses. Bull. Wld Hlth Org. 41, 447–452 (1969).

    CAS  Google Scholar 

  • Kasel, J. A., Fulk, R. V., Couch, R. B.: Communications. Antigenic relationship between the equine and the Hong Kong human variant of influenza Type A2 virus. J. Immunol. 102, 530–532 (1969).

    Google Scholar 

  • Kates, M., Allison, A. C., Tyrrell, D. A. J., James, A. T.: Lipids of influenza virus and their relation to those of the host cell. Biochim. biophys. Acta (Amst.) 52, 455–466 (1961).

    CAS  Google Scholar 

  • Kates, M., Allison, A. C., Tyrrell, D. A. J., James, A. T.: Origin of lipid in influenza virus. Cold Spr. Harb. Symp. quant. Biol. 27, 293–301 (1962).

    CAS  Google Scholar 

  • Kilbourne, E. D.: Recombination of influenza A viruses of human and animal origin. Science 160, 74–76 (1968).

    Google Scholar 

  • Kilbourne, E. D.: Influenza 1970: Unquestioned answers and unanswered questions. Arch, environm. Hlth 21, 286–292 (1970).

    CAS  Google Scholar 

  • Kilbourne, E. D.: Proc. 2nd International Congress for Virology (Budapest) ed. J. Melnick (In press, 1972 ).

    Google Scholar 

  • Kilbourne, E. D., Choppin, P. W., Schulze, I. T., Scholtissek, C., Bucher, D. L.: Influenza virus polypeptides and antigens—summary of influenza workshop I. J. infect. Dis. (In press, 1972).

    Google Scholar 

  • Kilbourne, E. D., Lief, F. S., Schulman, J. L., Jahiel, R. I., Laver, W. G.: Antigenic hybrids of influenza viruses and their implications, Perspect. Virol. 5, 87–106 (1967).

    Google Scholar 

  • Kilbourne, E. D., Schulman, J. L.: The induction of broadened (multitypic) immunity with doubly antigenic influenza virus recombinants. Trans. Ass. Amer. Phycns 78, 323–333 (1965).

    CAS  Google Scholar 

  • Kilbourne, E. D., Schulman, J. L., Schild, G. C., Schloer, G., Swanson, J., Bucher, D.: Correlated studies of a recombinant influenza-virus vaccine. 1. Derivation and characterization of virus and vaccine. J. infect. Dis. 124, 449–462 (1971).

    PubMed  CAS  Google Scholar 

  • Kingsbury, D. W.: Replication and functions of myxovirus ribonucleic acids. Progr. med. Virol. 12, 49–77 (1970).

    CAS  Google Scholar 

  • Kingsbury, D. W., Webster, R. G.: Some properties of influenza virus nucleocapsids. J. Virol. 4, 219–225 (1969).

    PubMed  CAS  Google Scholar 

  • Klenk, H.-D., Choppin, P. W.: Lipids of plasma membranes of monkey and hamster kidney cells and of parainfluenza virions grown in these cells. Virology 38, 255–268 (1969).

    PubMed  CAS  Google Scholar 

  • Klenk, H.-D., Choppin, P. W.: Plasma membrane lipids and parainfluenza virus assembly. Virology 40, 939–947 (1970).

    PubMed  CAS  Google Scholar 

  • Klenk, H.-D., Compans, R. W., Choppin, P. W.: An electron microscopic study of the presence or absence of neuraminic acid in enveloped viruses. Virology 42, 1158–1162 (1970).

    PubMed  CAS  Google Scholar 

  • Kundin, W. D.: Hong Kong A2 influenza virus infection among swine during a human epidemic in Taiwan. Nature (Lond.) 228, 857 (1970).

    CAS  Google Scholar 

  • Kundin, W. D., Easterday, B.C.: Hong Kong influenza infection in swine: experimental and field observations. Bull. Wld Hlth Org. (In press, 1971).

    Google Scholar 

  • Laidlaw, P. P.: Epidemic influenza: A virus disease. Lancet 19351, 1118–1128.

    Google Scholar 

  • Laver, W. G.: Peptide mapping of viral proteins. In: Fundamental techniques in virology, p. 371–378 ( K. Habel and N. P. Salzman, eds.). New York: Academic Press 1969.

    Google Scholar 

  • Laver, W. G.: Separation of two polypetptide chains from the hemagglutinin subunit of influenza virus. Virology 45, 275–288 (1971).

    PubMed  CAS  Google Scholar 

  • Laver, W. G., Valentine, R. C.: Morphology of the isolated hemagglutinin and neuraminidase subunits of influenza virus. Virology 38, 105–119 (1969).

    PubMed  CAS  Google Scholar 

  • Laver, W. G., Webster, R. G.: The structure of influenza viruses. IV. Chemical studies of the host antigen. Virology 30, 104–115 (1966).

    PubMed  CAS  Google Scholar 

  • Laver, W. G., Webster, R. G.: Selection of antigenic mutants of influenza viruses. Isolation and peptide mapping of their hemagglutinating proteins. Virology 34, 193–202 (1968).

    PubMed  CAS  Google Scholar 

  • Laver, W. G., Webster, R. G.: Studies on the origin of pandemic influenza. II. Peptide maps of the light and heavy polypeptide chains from the hemagglutinin subunits of A2 influenza viruses isolated before and after the appearance of Hong Kong influenza. Virology 48, 445–455 (1972).

    PubMed  CAS  Google Scholar 

  • Lazarowitz, S. G., Compans, R. W., Choppin, P. W.: Influenza virus structural and nonstructural proteins in infected cells and their plasma membranes. Virology 46, 830–843 (1971).

    PubMed  CAS  Google Scholar 

  • Lewandowski, L. J., Content, J., Leppla, S. H.: Characterization of the subunit structure of the ribonucleic acid genome of influenza virus. J. Virol. 8, 701–707 (1971).

    PubMed  CAS  Google Scholar 

  • Li, K. K., Seto, J. T.: Electron microscope study of ribonucleic acid of myxoviruses. J. Virol. 7, 524–530 (1971).

    PubMed  CAS  Google Scholar 

  • Loosli, C. G., Hamre, D., Gerber, P.: Antigenic variants of influenza A virus (PR 8 strain). V. Virulence, antigenic potency, and cross–protection tests in mice of the original and second series. J. exp. Med. 107, 857–868 (1958).

    CAS  Google Scholar 

  • Mackenzie, J. S.: Isolation of temperature–sensitive mutants and the construction of a preliminary genetic map for influenza virus. J. gen. Virol. 6, 63–75 (1970).

    PubMed  CAS  Google Scholar 

  • Marine, W. M., Workman, W. M.: Hong Kong influenza immunologic recapitulation. Amer. J. Epidem. 90, 406–415 (1969).

    CAS  Google Scholar 

  • Marine, W. M., Workman, W. M., Webster, R. G.: Immunological interrelationships of Hong Kong, Asian, and Equine–2 influenza viruses in man. Bull. Hlth Org. 41, 475–482 (1969).

    CAS  Google Scholar 

  • Masurel, N.: Antibody response obtained by vaccination with the influenza A/Equi 2 virus in man. Nature (Lond.) 218, 100–101 (1968).

    CAS  Google Scholar 

  • Masurel, N.: Relation between Hong Kong virus and former human A2 isolates and the A/Equi 2 virus in human sera collected before 1957– Lancet 19691, 907–910.

    Google Scholar 

  • Masurel, N., Mulder, J.: Studies on the content of antibodies for equine influenza viruses in human sera. Bull. Wld Hlth Org. 34, 885–893 (1966).

    CAS  Google Scholar 

  • McCahon, D., Schild, G. C.: An investigation of some factors affecting cross–reactivation between influenza A viruses. J. gen. Virol. 12, 207–219 (1971).

    PubMed  CAS  Google Scholar 

  • McQueen, J. L., Steele, J. H., Robinson, R. Q.: Influenza in animals. Advanc. vet. Sci. 12, 285–336 (1968).

    CAS  Google Scholar 

  • Meier-Ewert, H., Gibbs, A. J., Dimmock, N. J.: Studies on antigenic variations of the haemagglutinin and neuraminidase of swine influenza virus isolates. J. gen. Virol. 6, 409–419 (1970).

    PubMed  CAS  Google Scholar 

  • Minuse, E., McQueen, J. L., Davenport, F. M., Francis, T., Jr.: Studies of antibodies to 1956 and 1963 equine influenza viruses in horses and man. J. Immunol. 94, 563–566 (1965).

    PubMed  CAS  Google Scholar 

  • Mulder, J., Masurel, N.: Pre–epidemic antibody against 1957 strain of Asiatic influenza in serum of older people living in the Netherlands. Lancet 19581, 810–814.

    Google Scholar 

  • Paniker, C. K., Nair, C. M.: Infection with A2 Hong Kong influenza virus in domestic cats. Bull. Wld Hlth Org. 43, 859–862 (1970).

    CAS  Google Scholar 

  • Pereira, H. G.: Influenza. Antigenic spectrum. Progr. med. Virol. 11, 46–79 (1969).

    CAS  Google Scholar 

  • Pereira, H. G., Tumova, B., Webster, R. G.: Antigenic relationship between influenza A viruses of human and avian origins. Nature (Lond.) 215, 982–983 (1967).

    CAS  Google Scholar 

  • Pons, M. W.: On the nature of the influenza virus genome. Curr. Top. Microbiol. Im¬munol. 52, 142–157 (1970).

    CAS  Google Scholar 

  • Pons, M. W.: Isolation of influenza virus ribonucleoprotein from infected cells. Demon¬stration of the presence of negative–stranded RNA in viral RNP. Virology 46, 149–160 (1971).

    PubMed  CAS  Google Scholar 

  • Pons, M. W., Hirst, G. K.: Polyacrylamide gel electrophoresis of influenza virus RNA. Virology 34, 385–388 (1968).

    PubMed  CAS  Google Scholar 

  • Pons, M. W., Hirst, G. K.: The single and double-stranded RNAs and the proteins of incomplete influenza virus. Virology 38, 68–72 (1969).

    PubMed  CAS  Google Scholar 

  • Rasmussen, A. F.: Avian myxoviruses and man. In: Hanson Newcastle disease virus, an evolving pathogen, p. 313–325– Madison and Milwaukee: University of Wisconsin Press 1964.

    Google Scholar 

  • Rose, M. A.: Serological studies with equine influenza viruses. Brit. vet. J. 122, 435–442 (1966).

    Google Scholar 

  • Schafer, W., Wecker, E.: Über die Wirkung von Ribonuclease and 32P–markiertes gebundenes Antigen des Virus der Klassischen Geflügelpest. Arch. exp. Vet.–Med. 12, 418–422 (1958).

    CAS  Google Scholar 

  • Schild, G. C., Harkness, T. W., Lamart, P.: Antibodies to A2/Hong Kong/68 influenza virus in pigs in United Kingdom. Proc. 2nd International Congress for Virology (Budapest) ed. J. Melnick (In press, 1972 ).

    Google Scholar 

  • Schild, G. C., McCahon, D. Kendal, A. P.: Immunological and structural studies on a recombinant influenza A virus. In: The biology of larger RNA viruses, p. 638–654 ( R. D. Barry and B. W. J. Mahy, eds.). New York: Academic Press 1970.

    Google Scholar 

  • Schild, G. C., Newman, R. W.: Immunological relationships between the neuraminidases of human and animal influenza viruses. Bull. Wld Hlth Org. 41, 437–445 (1969).

    CAS  Google Scholar 

  • Schild, G. C., Pereira, H. G., Schettler, C. H.: Neuraminidase in avian influenza A virus antigenically related to that of human A0 and A± subtypes. Nature (Lond.) 222, 1299–1301 (1969).

    CAS  Google Scholar 

  • Schild, G. C., Stuart-Harris, C. H.: Serological epidemiological studies with influenza A viruses. J. Hyg. (Lond.) 63, 479–490 (1965).

    CAS  Google Scholar 

  • Schulman, J. L., Kilbourne, E. D.: Independent variation in nature of hemagglutinin and neuraminidase antigens of influenza virus: Distinctiveness of hemagglutinin antigen of Hong Kong/68 virus. Proc. nat. Acad. Sei. (Wash.) 63, 326–333 (1969).

    CAS  Google Scholar 

  • Schulze, I. T.: The structure of influenza virus. 1. The polypeptides of the virion. Virology 42, 890–904 (1970).

    PubMed  CAS  Google Scholar 

  • Schulze, I. T.: The structure of influenza virus. 2. A model based on the morphology and composition of subviral particles. Virology 47, 181–196 (1972).

    PubMed  CAS  Google Scholar 

  • Seto, J. T., Rott, R.: Functional significance of sialidase during influenza virus multi¬plication. Virology 30, 731–737 (1966).

    PubMed  CAS  Google Scholar 

  • Shatkin, A. J.: Viruses with segmented ribonucleic acid genomes: Multiplication of influenza versus reovirus. Bact. Rev. 35, 250–266 (1971).

    PubMed  CAS  Google Scholar 

  • Shope, R. E.: The influenzas of swine and man. Harvey Lect. 31, 183–213 (1935/36).

    Google Scholar 

  • Simpson, R. W.: Genetic studies with influenza A virus. Cellular biology of myxo virus infections. Ciba Foundation Symposium, p. 187–206 ( G. E. W. Wolstenholme and J. Knight, eds. ). 1964.

    Google Scholar 

  • Simpson, R. W., Hirst, G. K.: Genetic recombination among influenza viruses. I. Cross reactivation of plaque-forming capacity as a method for selecting recombinants from the progeny of crosses between influenza A strains. Virology 15, 436–451 (1961).

    PubMed  CAS  Google Scholar 

  • Simpson, R. W., Hirst, G. K.: Temperature-sensitive mutants of influenza A virus: Isolation of mutants and preliminary observations on genetic recombination and complementation. Virology 35, 41–49 (1968).

    PubMed  CAS  Google Scholar 

  • Skehel, J. J.: The characterization of subviral particles derived from influenza virus. Virology 44, 409–417 (1971a).

    PubMed  CAS  Google Scholar 

  • Skehel, J. J.: RNA-dependent RNA polymerase activity of the influenza virus. Virology 45, 793–796 (1971b).

    PubMed  CAS  Google Scholar 

  • Skehel, J. J.: Estimation of the molecular weight of the influenza virus genome. J. gen. Virol. 11, 103–109 (1971c).

    PubMed  CAS  Google Scholar 

  • Skehel, J. J., Schild, G. C.: The polypeptide composition of influenza A viruses. Virology 44, 396–408 (1971).

    PubMed  CAS  Google Scholar 

  • Staiger, H. R.: Plaque-type recombination in fowl plague virus. Virology 22, 419–422 (1964).

    PubMed  CAS  Google Scholar 

  • Stanley, P., Haslam, E. A.: The polypeptides of influenza virus. V. Localization of polypeptides in the virion by iodination techniques. Virology 46, 764–773 (1971).

    PubMed  CAS  Google Scholar 

  • Styk, B., Sabo, A., Blaskovic, O.: Antibodies to A2/Hong Kong/68 and A/Swine /Taiwan/7310/70 in pigs in Slovakia. Proc. 2nd International Congress for Virology (Budapest), ed. J. Melnick (In press, 1972 ).

    Google Scholar 

  • Sugiura, A., Kilbourne, E. D.: Genetic studies of influenza viruses. (3) Production of plaque-type recombinants of A0 and Ax strains. Virology 29, 84–91 (1966).

    PubMed  CAS  Google Scholar 

  • Taylor, J. M., Hampson, A. W., Layton, J. E., White, D. O.: The polypeptides of influenza virus. IV. An analysis of nuclear accumulation. Virology 42, 744–752 (1970).

    PubMed  CAS  Google Scholar 

  • Taylor, J. M., Hampson, A. W., White, D. O.: The polyppetides of influenza virus. 1. Cytoplasmic synthesis and nuclear accumulation. Virology 39, 419–425 (1969).

    PubMed  CAS  Google Scholar 

  • Tumova, B., Easterday, B. C.: Relationship of envelope antigens of animal influenza viruses to human A2 influenza strains isolated in the years 1957–68. Bull. Wld Hlth Org. 41, 429–435 (1969).

    CAS  Google Scholar 

  • Tumova, B., Pereira, H. G.: Genetic interaction between influenza A viruses of human and animal origin. Virology 27, 253–261 (1965).

    PubMed  CAS  Google Scholar 

  • Vogt, P. K.: Genetically stable reassortment of markers during mixed infection with avian tumor viruses. Virology 46, 947–952 (1971).

    PubMed  CAS  Google Scholar 

  • Webster, R. G.: Antigenic hybrids of influenza A viruses with surface antigens to order. Virology 42, 633–642 (1970).

    PubMed  CAS  Google Scholar 

  • Webster, R. G., Campbell, C. H., Granoff, A.: The “in vivo” production of “new” influenza A viruses. 1. Genetic recombination between avian and mammalian influenza viruses. Virology 44, 317–328 (1971).

    PubMed  CAS  Google Scholar 

  • Webster, R. G., Laver, W. G.: Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus. J. Immunol. 99, 49–55 (1967).

    PubMed  CAS  Google Scholar 

  • Webster, R. G., Laver, W. G.: Antigenic variation in influenza virus. Biology and chemistry. Progr. med. Virol. 13, 271–338 (1971).

    CAS  Google Scholar 

  • Webster, R. G., Laver, W. G.: Studies on the origin of pandemic influenza. I. Antigenic analysis of A2 influenza viruses (isolated before and after the appearance of Hong Kong influenza) using antisera to the isolated hemagglutinin subunits. Virology 48, 433–444 (1972).

    PubMed  CAS  Google Scholar 

  • Webster, R. G., Laver, W. G., Kilbourne, E. D.: Reactions of antibodies with surface antigens of influenza virus. J. gen. Virol. 3, 315–326 (1968).

    PubMed  CAS  Google Scholar 

  • Webster, R. G., Pereira, H. G.: A common surface antigen in influenza viruses from human and avian sources. J. gen. Virol. 3, 201–208 (1968).

    PubMed  CAS  Google Scholar 

  • W.H.O. Report: A revised system of nomenclature for influenza viruses. Bull. Wld Hlth Org. 45, 119–124 (1971).

    Google Scholar 

  • Young, R. J., Content, J.: 5′-Terminus of influenza virus RNA. Nature new Biol. (Lond.) 230, 140–142 (1971).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Virology, St. Jude Children’s Research Hospital, Memphis, Tennessee, 38101, USA

    Robert G. Webster

  2. Laboratory of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, 38101, USA

    Robert G. Webster

  3. The University of Tennessee Medical Units, Memphis, Tennessee, 38101, USA

    Robert G. Webster

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  1. Robert G. Webster
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Editors and Affiliations

  1. Basle, Switzerland

    W. Arber  & N. K. Jerne  & 

  2. New Brunswick, USA

    W. Braun

  3. Freiburg, Germany

    R. Haas

  4. Philadelphia, USA

    W. Henle , P. Koldovský  & H. Koprowski ,  & 

  5. Munich, Germany

    P. H. Hofschneider

  6. Copenhagen, Denmark

    O. Maaløe

  7. Gießen, Germany

    R. Rott

  8. Wilhelmshaven, Germany

    H. G. Schweiger

  9. Rehovot, Israel

    M. Sela

  10. Prague, Czech Republic

    L. Svruček

  11. Los Angeles, USA

    P. K. Vogt

  12. Würzburg, Germany

    E. Wecker

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© 1972 Springer-Verlag, Berlin · Heidelberg

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Webster, R.G. (1972). On the Origin of Pandemic Influenza Viruses. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65444-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-65444-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65446-6

  • Online ISBN: 978-3-642-65444-2

  • eBook Packages: Springer Book Archive

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