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Leukämie pp 57–94Cite as

Cytogenetik

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Zusammenfassung

Es kann nicht verwundern, daß in der Leukoseforschung die Analyse des Chromosomensatzes von Zellen der bhitbildenden Systeme eine theoretische, und bei dem technischen Stand der methodischen Zugänglichkeit der Chromosomen eine praktische Bedeutung gewonnen hat. Seit gut 80 Jahren, zuerst von v. Hansemann [24] und später von Boveri [4], wird die Frage des Verlustes des chromosomalen Gleichgewichts als einer moglichen Atiologie oder zumindest als wesentlichem Kriterium der Geschwtilste diskutiert [54 b]. Die moderneren Methoden und die nachhaltig-stimulierende Wirkung, die die spektakulare Entdeckung des PhChromosoms durch NOWELL und HUNGERFORD [52, 53] bei der chronis chen myeloischen Leukamie unter Hamatologen hervorrief, haben diese Diskussion in einen praktisch wichtigeren Bereich geführt und dürften ihr auch eine solidere Grundlage geben.

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Authors and Affiliations

  1. Abteilung für Kinderpathologie am Pathologischen Institut, Universität Bonn, Deutschland

    S. Mende

  2. Medizinischen Universitätsklinik Köln, Deutschland

    K. P. Hellriegel

  3. Abteilung für Hämatologie, Zentrum für Innere Medizin und Kinderheilkunde, Universität Ulm (Donau), Deutschland

    H. Heimpel

  4. Innere Klinik und Poliklinik (Tumorforschung), Klinikum Essen der Ruhr-Universitat Bochum, Buffalo, USA

    A. A. Sandberg

  5. Roswell Park Memorial Institute, Buffalo, USA

    A. A. Sandberg

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  1. A. Gropp
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  2. S. Mende
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  3. W. Lehmann
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  4. K. P. Hellriegel
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  5. J. Bauke
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  9. A. A. Sandberg
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    Rudolf Gross (Direktor) & Jurgen van de Loo (Direktor) & 

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Gropp, A. et al. (1972). Cytogenetik. In: Gross, R., van de Loo, J. (eds) Leukämie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65436-7_3

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