Summary
The concentration dependence of glutamate uptake is described as the sum of a saturable (mechanism I) and a nonsaturable (mechanism II) component. Lowering the pH does not influence mechanism II, but stimulates mechanism I.
Na+ and K+ activate both mechanisms at neutral pH. No influence of Na+ and K+ on the uptake was observed at low pH.
The transport of glutamate is inhibited by neutral amino acids. As the pH increases the inhibition of mechanism II increases, while for mechanism I the inhibition decreases.
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References
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© 1972 Springer-Verlag Berlin · Heidelberg
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Geck, P., Pfeiffer, B. (1972). The Influence of H+, Na+ and K+ on the Influx of Glutamate in Ehrlich Ascites-Tumor Cells. In: Heinz, E. (eds) Na-linked Transport of Organic Solutes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65404-6_10
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DOI: https://doi.org/10.1007/978-3-642-65404-6_10
Publisher Name: Springer, Berlin, Heidelberg
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