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The Influence of H+, Na+ and K+ on the Influx of Glutamate in Ehrlich Ascites-Tumor Cells

  • P. Geck
  • B. Pfeiffer

Summary

The concentration dependence of glutamate uptake is described as the sum of a saturable (mechanism I) and a nonsaturable (mechanism II) component. Lowering the pH does not influence mechanism II, but stimulates mechanism I.

Na+ and K+ activate both mechanisms at neutral pH. No influence of Na+ and K+ on the uptake was observed at low pH.

The transport of glutamate is inhibited by neutral amino acids. As the pH increases the inhibition of mechanism II increases, while for mechanism I the inhibition decreases.

Keywords

Acidic Medium Glutamate Uptake Neutral Amino Acid Neutral Medium Acidic Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    HEINZ, E., LOEWE, U., DESPOPOULOS, A., PFEIFFER, B.: Biochem. Z. 340, 487 (1964).Google Scholar
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    HEINZ, E., PICHLER, A. G., PFEIFFER, B.: Biochem. Z. 342, 542(1965).Google Scholar
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    PICHLER, A. G.: Biochim. Biophys. Acta 104, 104 (1965).Google Scholar
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    GROBECKER, H., KROMPHARDT, H., MARIANI, H., HZ, E.: Biochem. Z. 337, 462 (1963).Google Scholar
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    HEINZ, E.: J. Biol. Chem. 211, 781 (1954).Google Scholar
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    KROMPHARDT, H.: Biochem. Z. 343, 283 (1965).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • P. Geck
    • 1
  • B. Pfeiffer
    • 1
  1. 1.Institut für vegetative Physiologie der Universität Frankfurt/MainGermany

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