The Influence of H+, Na+ and K+ on the Influx of Glutamate in Ehrlich Ascites-Tumor Cells

  • P. Geck
  • B. Pfeiffer


The concentration dependence of glutamate uptake is described as the sum of a saturable (mechanism I) and a nonsaturable (mechanism II) component. Lowering the pH does not influence mechanism II, but stimulates mechanism I.

Na+ and K+ activate both mechanisms at neutral pH. No influence of Na+ and K+ on the uptake was observed at low pH.

The transport of glutamate is inhibited by neutral amino acids. As the pH increases the inhibition of mechanism II increases, while for mechanism I the inhibition decreases.


Acidic Medium Glutamate Uptake Neutral Amino Acid Neutral Medium Acidic Amino Acid 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • P. Geck
    • 1
  • B. Pfeiffer
    • 1
  1. 1.Institut für vegetative Physiologie der Universität Frankfurt/MainGermany

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