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Wirkung hoher Sauerstoffdrucke auf das Zentralnervensystem

  • R. Purschke
Part of the Anaesthesiology and Resuscitation Anaesthesiologie und Wiederbelebung Anesthésiologie et Réanimation book series (A+I, volume 64)

Zusammenfassung

Es ist seit langem bekannt, daß Sauerstoff ein Gift darstellt, das bei längerer Applikation in hohen Konzentrationen tödlich wirkt. Klinische und experimentelle Befunde legen die Annahme nahe, daß das Gehirn zu den Organen gehört, die auf hohe Sauerstoffdrucke besonders empfindlich reagieren.

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References

  1. 1.
    Anderson, B., Saltzman, H. A.: Hyperbaria, Hybaroxia, and the Retinal and Cerebral Vessels. Headache 5, 73 (1965).PubMedCrossRefGoogle Scholar
  2. 2.
    Anderson, B., McIntosh, H. D.: Retinal Circulation. Ann. Rev. Med. 18, 15 (1967).PubMedCrossRefGoogle Scholar
  3. 3.
    Balentine, J. D.: Pathologic Effects of Exposure to High Oxygen Tensions. New Engl. J. Med. 275, 1038 (1966).PubMedCrossRefGoogle Scholar
  4. 4.
    Balentine, J. D., Gutsche, B. B.: Central Nervous System Lesions In Rats Exposed To Oxygen At High Pressure. Amer. J. Pathol. 48, 107 (1966).Google Scholar
  5. 5.
    Balentine, J. D., Gutsche, B. B.: Pathogenesis of Central Nervous System Lesions Induced by Exposure to Hyperbaric Oxygen. Amer. J. Path. 53, 1097 (1968).PubMedGoogle Scholar
  6. 6.
    Bean, J. W.: Factors Influencing Clinical Oxygen Toxicity. Ann. N. Y. Acad. Sci. 117, 745 (1965).PubMedGoogle Scholar
  7. 7.
    Bert, P.: La Pression Barometrique. Paris, France 1878 (zit. n. Zirkle et al. [32]).Google Scholar
  8. 8.
    Desai, I. D., Tappel, A. L.: Damage to proteins by peroxidized lipids. J. Lipid Res. 4, 204 (1963).PubMedGoogle Scholar
  9. 9.
    Gillen, H. W.: Oxygen Convulsions in Man. Proc. III. Int. Conf. Hyberbaric Medicine 1, 217 (1966).Google Scholar
  10. 10.
    Gottlieb, S. F., Jagodzinski, R. V.: Role of THAM in protecting mice agains convulsive episodes caused by exposure to oxygen under high pressure. Proc. Soc. exp. Biol. 112, 427 (1963).PubMedGoogle Scholar
  11. 11.
    Goulon, M., Levy-Alcover, M. A., Nouailhat, F., Dordain, G.: The EEG in hyperbaric oxygen therapy. Electroenceph. clin. Neurophysiol. 25, 90 (1968).PubMedGoogle Scholar
  12. 12.
    Gutsche, B. B., Harp, J. R., Stephen, C. R.: Physiologic Responses of the Anesthetized Dog to Oxygen at Five Atmospheres Absolute. Anesthesiology 27, 615 (1966).PubMedCrossRefGoogle Scholar
  13. 13.
    Harel, D., Kerem, D., Lavy, S.: The Influence of high Oxygen Pressure on the Electrical Activity of the Brain. Electroenceph. clin. Neurophysiol. 26, 310 (1969).PubMedCrossRefGoogle Scholar
  14. 14.
    Harp, J. R., Gutsche, B. B., Stephen, C. R.: Effect of Anesthetics on Central Nervous System Toxicity of Hyperbaric Oxygen. Anesthesiology 27, 608 (1966).PubMedCrossRefGoogle Scholar
  15. 15.
    Haugaard, N.: Poisoning of Cellular Reactions by Oxygen. Ann. N. Y. Acad. Sci. 117, 736 (1965).PubMedGoogle Scholar
  16. 16.
    Haugaard, N.: Cellular Mechanism of Oxygen Toxicity. Physiol. Rev. 48, 311 (1968).PubMedGoogle Scholar
  17. 17.
    Hollin, J. S. A., Espinosa, O. E., Sukoff, M. H., Jacobson, J. W.: The Effect of Hyperbaric Oxygenation on Cerebrospinal Fluid Oxygen. J. Neurosurg. 29, 229 (1968).PubMedCrossRefGoogle Scholar
  18. 18.
    Jamieson, D., Van den Brenk, H. A. S.: The Effects of Antioxidants on High Pressure Oxygen Toxicity. Biochem. Pharmacol. 13, 159 (1964).PubMedCrossRefGoogle Scholar
  19. 19.
    Joanny, P., Corriol, J., Brue, F.: Hyperbaric Oxygen: Effects on Metabolism and Ionic Movement in Cerebral Cortex Slices. Science 167, 1510 (1970).CrossRefGoogle Scholar
  20. 20.
    Kann, H. E., Mengel, C. E., Smith, W., Horton, B.: Oxygen toxicity and vitamin E. Aerospace Med. 35, 840 (1964).PubMedGoogle Scholar
  21. 21.
    Kaplan, S. A., Stein, S. N.: Effects of Oxygen at high Pressure on the Transport of Potassium, Sodium and Glutamate in Guinea Pig Brain Cortex. Amer. J. physiol. 190, 157 (1957).PubMedGoogle Scholar
  22. 22.
    Kety, S. S., Schmidt, C. F.: The Effects of altered arterial Tensions of Carbon Dioxide and Oxygen on Cerebral Blood Flow and cerebral Oxygen Consumption of normal young men. J. clin. Invest. 27, 484 (1948).CrossRefGoogle Scholar
  23. 23.
    Lambertsen, C. J., Kough, R. H., Cooper, D. Y., Emmel, G. L., Loeschcke, H. H., Schmidt, C. F.: Oxygen Toxicity. Effects in Man of Oxygen Inhalation at 1 and 3,5 Atmospheres Upon Bloot Gas Transport, Cerebral Circulation and Cerebral Metabolism. J. appl. Physiol. 5, 471 (1953).PubMedGoogle Scholar
  24. 24.
    Lambertsen, C. J., Ewing, J. H., Kough, R. H., Gould, R., Stroud, M. W.: Oxygen Toxicity. Arterial and Internal Jugular Blood Gas Composition in Man During Inhalation of Air, 100 % O2 and 2 % CO2 in O2 at 3,5 Atmospheres Ambient Pressure. J. appl. Physiol. 8, 255 (1955).PubMedGoogle Scholar
  25. 25.
    Ledingham, McA., Mcdowall, D. G., Harper, A.M.: Cerebral Cortical Blood Flow Under Hyperbaric Conditions. Proc. III. Int. Conf. Hyperbaric Medicine, 243 (1966).Google Scholar
  26. 26.
    Sanders, A. P., Hall, I. H., Cavanaugh, P. J., Woodhall, B.: Effects of hyperbaric oxygenation on metabolism. I. ATP-concentration in rat brain, liver and kidney. Proc. Soc. exp. Biol. 121, 32–34 (1966).PubMedGoogle Scholar
  27. 27.
    Shcherbakova, G. V.: Activity of glutamic decarboxylase and the content of γ-aminobutyric acid in rat brain at various levels of functional state caused by increased pressure of oxygen. Dokl. Akad. Nauk. SSSR 146, 1213 (1962) (zit. bei Haugaard [16]).Google Scholar
  28. 28.
    Thomas, J. J., Neptune, E. M., Sudduth, H. C.: Toxic Effects of Oxygen at High Pressure on the Metabolism of D-Glucose by Dispersion of Rat Brain. Biochem. J. 88, 31 (1963).PubMedGoogle Scholar
  29. 29.
    Voronov, I. B.: Brain Structures and Origin of Convulsions Caused by High Oxygen Pressure (HOP). Int. J. Neuropharmacol. 3, 279 (1964).PubMedCrossRefGoogle Scholar
  30. 30.
    van den Brenk, H. A. S., Jamieson, D.: Brain damage and paralysis in animals exposed to high pressure oxygen — Pharmacological and biochemical observations. Biochem. Pharmacol. 13, 165 (1964).CrossRefGoogle Scholar
  31. 31.
    Wood, J. D., Watson, W. J., Murray, G. W.: Correlation between Decreases in Brain γ-Aminobutyric Acid Levels and Susceptibility to Convulsions induced by Hyperbaric Oxygen. J. Neurochem. 16, 281 (1969).PubMedCrossRefGoogle Scholar
  32. 32.
    Zirkle, L. G., Mengel, C. E., Horton, B. D., Duffy, E. J.: Studies of Oxygen Toxicity in the Central Nervous System. Aerospace Med. 36, 1027 (1965).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1972

Authors and Affiliations

  • R. Purschke
    • 1
  1. 1.Institut für AnästhesiologieUniversität DüsseldorfDeutschland

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