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The Morphogenesis of Poliovirus

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Book cover Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 58))

Abstract

Poliovirus is one of the simplest and most extensively studied animal viruses. Yet, in spite of the voluminous literature, many basic and important questions concerning its morphogenesis remain unanswered. For example, what mechanisms insure that the progeny virus retain the precise structural features of the infecting particle ? How does the viral RNA combine with the capsid proteins to form the virion and how are host RNA molecules excluded from this process ? Do non-capsid viral proteins influence these events ? Thus, while infectious tobacco mosaic virus particles have been reconstituted in vitro from viral RNA and protein monomers, both obtained by controlled degradation of the virion, it remains to be shown that this is in fact the mechanism of morphogenesis in vivo.

I acknowledge the many helpful criticisms of Drs. J. S. Youngner and H. Thacore during the preparation of this review. This review was aided by Award No. AI-08368 from the National Institutes of Health.

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Authors
  1. Bruce A. Phillips
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Editor information

Editors and Affiliations

  1. Basle, Switzerland

    W. Arber

  2. New Brunswick, USA

    W. Braun

  3. Freiburg, Germany

    R. Haas

  4. Philadelphia, USA

    W. Henle , P. Koldovský  & H. Koprowski ,  & 

  5. Munich, Germany

    P. H. Hofschneider

  6. Basle, Switzerland

    N. K. Jerne

  7. Copenhagen, USA

    O. Maaløe

  8. Gieβen, Germany

    R. Rott

  9. Wilhelmshaven, Germany

    H. G. Schweiger

  10. Rehovot, UK

    M. Sela

  11. Prague, USA

    L. Syruček

  12. Los Angeles, USA

    P. K. Vogt

  13. Würzburg, Germany

    E. Wecker

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© 1972 Springer-Verlag, Berlin · Heidelberg

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Phillips, B.A. (1972). The Morphogenesis of Poliovirus. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 58. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65357-5_5

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  • DOI: https://doi.org/10.1007/978-3-642-65357-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

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