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Experimental Thyroid Carcinogenesis

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Book cover Current Topics in Pathology / Ergebnisse der Pathologie

Part of the book series: Current Topics in Pathology / Ergebnisse der Pathologie ((CT PATHOLOGY,volume 56))

Abstract

Thyroid carcinomas have recently become one of the main problems in theoretical, experimental and clinical oncology. This is due, on the one hand, to their specific biological properties with regard to growth, metastasis, functional activity, hormonal control, radiobiological changes after treatment with 131I and resistance to antitumour agents, and, on the other hand, to the possibility of studying them by means of radioactive iodine. There is no other type of tumour in the human body presenting a more favourable target for functional investigations than thyroid tumours. The wide use of radioactive iodine in the diagnosis and treatment of thyroid diseases inevitably brought up the problem of its carcinogenic effect. Experimental data and some clinical observations show that radioactive iodine (131I) is able to cause thyroid tumours both in animals and in man. The increased incidence of thyroid cancer among patients irradiated in childhood for thymic enlargement is indicative of the significant participation of X-ray irradiation in thyroid carcinogenesis.

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Authors and Affiliations

  1. Deparment of Pathology and Carcinogenesis, Cancer Research Institute, Sofia, Bulgaria

    Konstantin Christov & Raiko Raichev

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  1. Konstantin Christov
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Editors and Affiliations

  1. Würzburg, Germany

    H.-W. Altmann

  2. La Jolla, USA

    K. Benirschke

  3. Tübingen, Germany

    A. Bohle

  4. Chapel Hill, USA

    K. M. Brinkhous

  5. Hannover, Germany

    P. Cohrs

  6. Bern, Switzerland

    H. Cottier

  7. München, Germany

    M. Eder

  8. Bonn, Germany

    P. Gedigk

  9. Münster, Germany

    W. Giese

  10. Zürich, Switzerland

    Chr. Hedinger

  11. Hiroshima, Japan

    S. Iijima

  12. Chicago, USA

    W. H. Kirsten

  13. Bethesda, USA

    I. Klatzo

  14. Kiel, Germany

    K. Lennert

  15. Düsseldorf, Germany

    H. Meessen

  16. Freiburg, Germany

    W. Sandritter

  17. Hamburg, Germany

    G. Seifert

  18. New York, USA

    H. C. Stoerk

  19. Basel, Switzerland

    H. U. Zollinger

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Christov, K., Raichev, R. (1972). Experimental Thyroid Carcinogenesis. In: Altmann, HW., et al. Current Topics in Pathology / Ergebnisse der Pathologie. Current Topics in Pathology / Ergebnisse der Pathologie, vol 56. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65324-7_3

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