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Catecholamines pp 336–362Cite as

Classification of Sympathomimetic Amines

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Abstract

Long before the mechanism of action of the indirectly acting sympathomimetic amines was understood, it was clear that the amines of this group differ pharmacologically. For instance, while cocaine potentiates the effects of adrenaline (FröHlich and Loewi, 1910) it antagonizes the effects of tyramine (Tainter and Chang, 1927). A parallel to this “cocaine paradox” was observed after chronic sympathetic denervation, a procedure which potentiates the effects of adrenaline and antagonizes those of tyramine (Burn and Tainter, 1931; Bülbring and Burn, 1938).

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References

  • Axelrod, J., Gordon, E., Hertting, G., Kopin, I. J., Potter, L. T.: On the mechanism of tachyphylaxis to tyramine in the isolated rat heart. Brit. J. Pharmacol. 19, 56–63 (1962).

    PubMed  CAS  Google Scholar 

  • Barger, G., Dale, H.H.: Chemical structure and sympathomimetic action of amines. J. Physiol. (Lond.) 41, 19–59 (1910).

    CAS  Google Scholar 

  • Barnett, A., Staub, M., Symchowicz, S.: The effect of cocaine and imipramine on tyramine-induced release of noradrenaline–3H from the rat vas deferens in vitro. Brit. J. Pharmacol. 36, 79–84 (1969).

    CAS  Google Scholar 

  • Benfey, B.G., Varma, D.R.: Studies on the cardiovascular actions of antisympathomimetic drugs. Int. J. Neuropharmacol. 1, 9–12 (1962).

    CAS  Google Scholar 

  • Bhagat, B., Shideman, F.E.: Mechanism of the positive inotropic response to bretylium and guanethidine. Brit. J. Pharmacol. 20, 56–62 (1963).

    PubMed  CAS  Google Scholar 

  • Birmingham, A.T., Wilson, A.B.: An analysis of the blocking action of dimethylphenyl-piperazinium iodide on the inhibition of isolated small intestine produced by stimulation of the sympathetic nerves. Brit. J. Pharmacol. 24, 375–386 (1965).

    PubMed  CAS  Google Scholar 

  • Brimijoin, S., Trendelenburg, U.: Reserpine-induced release of norepinephrine from isolated spontaneously beating guinea-pig atria. J. Pharmacol, exp. Ther. 176, 149–159 (1971).

    CAS  Google Scholar 

  • Bulbring, E., Burn, J.H.: The action of tyramine and adrenaline on the denervated nictitating membrane. J. Physiol. (Lond.) 91, 459–473 (1938). BURN, J. H.: The action of tyramine and ephedrine. J. Pharmacol, exp. Ther. 46, 75–95 (1932).

    Google Scholar 

  • Bulbring, E., Burn, J.H., Rand, M.J.: Reserpine and adrenaline in arterial walls. Lancet 273, 1097 (1957).

    Google Scholar 

  • Bulbring, E., Burn, J.H., Rand, M.J.: The action of sympathomimetic amines in animals treated with reserpine. J. Physiol. (Lond.) 144, 314–336 (1958).

    Google Scholar 

  • Bulbring, E., Burn, J.H., Rand, M.J., Tainter, M. L.: An analysis of the effect of cocaine on the action of adrenaline and tyramine. J. Physiol. (Lond.) 71, 169–193 (1931).

    Google Scholar 

  • Carlsson, A., Hillarp, N.-A., Waldeck, B.: Analysis of the Mg++-ATP dependent storage mechanism in the amine granules of the adrenal medulla. Acta physiol, scand. 59, Suppl. 215, 38pp (1963).

    Google Scholar 

  • Carlsson, A., Rosengren, E., Bertler, A., Nilsson, J.: Effect of reserpine on the metabolism of catechol amines. Psychotropic drugs, pp. 363–372. Amsterdam-London-New York-Princeton: Elsevier Publishing Co. 1957.

    Google Scholar 

  • Carlsson, A., Rosengren, E., Bertler, A., Nilsson, J., Waldeck, B.: Structure-activity relationships for release of 14C-octopamine from adrenergic nerves by phenylethylamines. Acta pharmacol. (Kbh.) 24, 255–262 (1966).

    CAS  Google Scholar 

  • Chang, P.: Sympathomimetic actions of phenoxybenzamine on rat heart. Europ. J. Pharmacol. 4, 240–245 (1968).

    CAS  Google Scholar 

  • Commarato, M.A., Brody, T.M., Mcneill, J.H.: The effect of various drugs on the uptake and metabolism of tyramine-H3 in the rat heart. J. Pharmacol, exp. Ther. 167, 151 to 158 (1969).

    Google Scholar 

  • Croft, J. R.: The uptake and release of H+norepinephrine by the guinea-pig heart in vivo. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 248, 85–98 (1964).

    Google Scholar 

  • Croft, J. R., Muskus, A. J., Trendelenburg, U.: Effect of tyramine on isolated guinea-pig atria in relation to their noradrenaline stores. Brit. J. Pharmacol. 18, 600–611 (1962).

    Google Scholar 

  • De La Lande, I. S., Waterson, J. G.: The action of tyramine on the rabbit ear artery. Brit. J. Pharmacol. 34, 8–18 (1968).

    Google Scholar 

  • Drasköczy, P.R., Trendelenburg, U.: The uptake of 1-and d-norepinephrine by the isolated perfused rabbit heart in relation to the stereospecificity of the sensitizing action of cocaine. J. Pharmacol, exp. Ther. 159, 66–73 (1968).

    Google Scholar 

  • Drasköczy, P.R., Trendelenburg, U.: Intraneuronal and extraneuronal accumulation of sympathomimetic amines in the isolated nictitating membrane of the cat. J. Pharmacol, exp. Ther. 174, 290–306 (1970).

    Google Scholar 

  • Eade, N. R.: The release of catechol amines from isolated chromaffin granules. Brit. J. Pharmacol. 12, 61–65 (1957).

    PubMed  CAS  Google Scholar 

  • Eade, N. R.: Mechanism of sympathomimetic action of aldehydes. J. Pharmacol, exp. Ther. 127, 29–34 (1959).

    CAS  Google Scholar 

  • Von Euler, U.S., Lishajko, F.: Uptake of 1-and d-isomers of catecholamines in adrenergic nerve granules. Acta physiol. scand. 60, 217–222 (1964).

    CAS  Google Scholar 

  • Von Euler, U.S., Lishajko, F.: The uptake of isoprenaline in nerve granules. Int. J. Neuropharmacol. 6, 431–434 (1967).

    Google Scholar 

  • Fleckenstein, A.: Uber Neuro-Sympathomimetica. Verhandl. der Deutschen Ges. f. inn. Med., 59. Kongress, 1953, p. 17–22.

    Google Scholar 

  • Fleckenstein, A., Bass, H.: Zum Mechanismus der Wirkungsverstärkung und Wirkungsabschwächung sympathomimetischer Amine durch Cocain und andere Pharmaka. I. Die Sensibilisierung der Katzen-Nickhaut für Sympathomimetica der Brenzkatechin-Reihe. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 220, 143–156 (1953).

    CAS  Google Scholar 

  • Fleckenstein, A., Bass, H., Burn, J.H.: The effect of denervation on the action of sympathomimetic amines on the nictitating membrane. Brit. J. Pharmacol. 8, 69–78 (1953).

    PubMed  CAS  Google Scholar 

  • Fleckenstein, A., Bass, H., Burn, J.H., Stöckle, D.: Zum Mechanismus der Wirkungsverstärkung und Wirkungsabschwächung sympathomimetischer Amine durch Cocain und andere Pharmaka. II. Die Hemmung der Neuro-Sympathomimetica durch Cocain. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 224, 401–415 (1955).

    CAS  Google Scholar 

  • Fleming, W.W., Trendelenburg, U.: Development of supersensitivity to norepinephrine after pretreatment with reserpine. J. Pharmacol, exp. Ther. 133, 41–51 (1961).

    CAS  Google Scholar 

  • Fröhlich, A., Loewi, O.: Untersuchungen zur Physiologie und Pharmakologie des vegetativen Nervensystems. II. Mitteilung: Über eine Steigerung der Adrenalinempfindlichkeit durch Cocain. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 62, 159–169 (1910).

    Google Scholar 

  • Furchgott, R.F., Kirpekar, S.M.: Release of catecholamines in heart by /Mialoalkylamines and by bretylium. Pharmacologist 2, 93 (1960).

    Google Scholar 

  • Furchgott, R.F., Kirpekar, S.M.: Competition between /Mialoalkylamines and norepinephrine for sites in cardiac muscle. Proceedings of the First International Pharmacological Meeting, vol. 7, pp. 339–350. Oxford: Pergamon Press 1963.

    Google Scholar 

  • Giachetti, A., Shore, P.A.: Optical specificity of monoamine oxidase. Life Sci. 5, 1373–1378 (1966).

    CAS  Google Scholar 

  • Grobecker, H., Holtz, P., Jonsson, J.: Über die Wirkung des Tyramins auf den isolierten Darm. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 255, 491–509 (1966).

    CAS  Google Scholar 

  • Gulati, O.S., Kelkar, V.V.: Effect of tyramine on human umbilical artery in vitro. Brit. J. Pharmacol. 42, 155–158 (1971).

    CAS  Google Scholar 

  • Haeusler, G.: Early pre-and postfunctional effects of 6-hydroxydopamine. J. Pharmacol, exp. Ther. 178, 49–62 (1971).

    CAS  Google Scholar 

  • Hamilton, T.C.: Modification of the vascular response to isoprenaline by cholinomimetic drugs. Brit. J. Pharmacol. 42, 254–262 (1971).

    CAS  Google Scholar 

  • Harrison, D.C., Chidsey, C.A., Goldman, R., Braunwald, E.: Relationships between the release and tissue depletion of norepinephrine from the heart by guanethidine and reserpine. Circulat. Res. 12, 256–263 (1963).

    PubMed  CAS  Google Scholar 

  • Hertting, G.: The fate of 3H-isoproterenol in the rat. Biochem. Pharmacol. 13, 1119–1128 (1964).

    PubMed  CAS  Google Scholar 

  • Hertting, G., Axelrod, J., Patrick, R.W.: Actions of bretylium and guanethidine on the uptake and release of (3H)-noradrenaline. Brit. J. Pharmacol. 18, 161–166 (1962).

    PubMed  CAS  Google Scholar 

  • Holtz, P., Osswald, W., Stock, K.: Über die Beeinflussung der Wirkungen sympathicomi-metischer Amine durch Cocain und Reserpin. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 239, 14–28 (1960).

    CAS  Google Scholar 

  • Holtz, P., Osswald, W., Stock, K., Palm, D.: Über den Mechanismus der sympathicomimetischen Wirkungen einiger ali-phatischer Amine. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 251, 144–158 (1965).

    Google Scholar 

  • Horita, A.: A vasopressor response to reserpine in the cocainized dog. J. Pharmacol, exp. Ther. 122, 474–479 (1958).

    CAS  Google Scholar 

  • Hoszowska-Owczarek, A., Langer, S.Z., Djordjevic, N., De Schaepdryver, A.F.: Stimulant action of tolazoline on the nictitating membrane of the pithed cat. Arch. int. Pharmacodyn. 174, 135–143 (1968).

    CAS  Google Scholar 

  • Hoszowska-Owczarek, A., Langer, S.Z., Djordjevic, N., De Schaepdryver, A.F., Nnes, I.R.: An action of 5-hydroxytryptamine on adrenaline receptors. Brit. J. Pharmacol. 19, 427–441 (1962).

    Google Scholar 

  • Hoszowska-Owczarek, A., Langer, S.Z., Djordjevic, N., De Schaepdryver, A.F., Kohli, J.D.: Excitatory action of sympathomimetic amines on 5-hydroxytryptamine receptors of gut. Brit. J. Pharmacol. 35, 383–393 (1969).

    Google Scholar 

  • Iversen, L.L.: The uptake of noradrenaline by the isolated perfused rat heart. Brit. J. Pharmacol. 21, 523–537 (1963).

    PubMed  CAS  Google Scholar 

  • Iversen, L.L.: The uptake and storage of noradrenaline in sympathetic nerves, 253 pages. Cambridge, England: Cambridge University Press 1967.

    Google Scholar 

  • Jacquot, C., Bralet, J., Cohen, Y., Valette, G.: Fixation de la dl-ephedrine–14C par le coeur isole perfuse de rat. Biochem. Pharmacol. 18, 903–914 (1969).

    PubMed  CAS  Google Scholar 

  • Kadzielawa, K.: Mechanism of action of guanethidine. Brit. J. Pharmacol. 19, 74–84 (1962).

    PubMed  CAS  Google Scholar 

  • Kalsner, S.: Effects of tyramine on responses to and inactivation of histamine in aortic strips. J. Pharmacol, exp. Ther. 175, 489–495 (1970).

    CAS  Google Scholar 

  • Kirpekar, S.M., Furchgott, R.F.: The sympathomimetic action of bretylium on isolated atria and aortic smooth muscle. J. Pharmacol, exp. Ther. 143, 64–76 (1964).

    CAS  Google Scholar 

  • Kopin, I. J., Bridgers, W.: Differences in d-and 1-norepinephrine-H3. Life Sci. 2, 356–362 (1963).

    Google Scholar 

  • Kopin, I. J., Bridgers, W., Fischer, J.E., Mttsacchio, J.M., Horst, W.D., Weise, V.K.: “False neurochemical transmitters” and the mechanism of sympathetic blockade by monoamine oxidase inhibitors. J. Pharmacol, exp. Ther. 147, 186–193 (1965).

    CAS  Google Scholar 

  • Krayer, O, Alper, M.H., Paasonen, M.K.: Action of guanethidine and reserpine upon the isolated mammalian heart. J. Pharmacol, exp. Ther. 135, 164–173 (1962).

    CAS  Google Scholar 

  • Krayer, O, Alper, M.H., Paasonen, M.K., Langer, S. Z.: Presence of tone in the denervated and in the decentralized nictitating membrane of the spinal cat and its influence on determinations of supersensitivity. J. Pharmacol, exp. Ther. 154, 14–34 (1966).

    Google Scholar 

  • Krayer, O, Alper, M.H., Paasonen, M.K., Drasköczy, P.R., Trendelenburg, U.: Time course of the development of supersensitivity to various amines in the nictitating membrane of the pithed cat after denervation or decentralization. J. Pharmacol, exp. Ther. 157, 255–273 (1967).

    Google Scholar 

  • Lee, F. L.: The relation between norepinephrine content and response to sympathetic nerve stimulation of various organs of cats pretreated with reserpine. J. Pharmacol, exp. Ther. 156, 137–141 (1967).

    CAS  Google Scholar 

  • Lee, F. L., Weiner, N., Trendelenburg, U.: The uptake of tyramine and formation of octopamine in normal and tachyphylactic rat atria. J. Pharmacol, exp. Ther. 155, 211–222 (1967).

    CAS  Google Scholar 

  • Lee, W.C., Shin, Y.H., Shideman, F.E.: Cardiac activities of several monoamine oxidase inhibitors. J. Pharmacol, exp. Ther. 133, 180–185 (1961).

    CAS  Google Scholar 

  • Liebman, J.: Modification of the chronotropic action of sympathomimetic amines by reserpine in the heart-lung preparation of the dog. J. Pharmacol, exp. Ther. 133, 63–69 (1961).

    CAS  Google Scholar 

  • Liebman, J., Muskus, A. J., Waud, D.R.: The depletion of norepinephrine stores in the heart of the dog by reserpinetype alkaloids. J. Pharmacol, exp. Ther. 136, 76–79 (1962).

    Google Scholar 

  • Lindmar, R.: Die Wirkung von 1, 1-Dimethyl–4-Phenyl-Piperazinium-Jodid am isolierten Vorhof im Vergleich zur Tyramin-und Nicotinwirkung. Naunyn-Schmiedeberg’s Arch, exp. Pathol. Pharmakol. 242, 458–466 (1962).

    CAS  Google Scholar 

  • Lindmar, R., Löffelholz, K., Muscholl, E.: Unterschiede zwischen Tyramin und Dimethylphenyl-piperazin in der Ca++-Abhängigkeit und im zeitlichen Verlauf der Noradrenalin-Freisetzung am isolierten Kaninchenherzen. Experientia (Basel) 23, 933–934 (1967).

    CAS  Google Scholar 

  • Lindmar, R., Löffelholz, K., Muscholl, E., Muscholl, E.: Die Wirkung von Cocain, Guanethidin, Reserpin, Hexamethonium, Tetracain und Psicain auf die Noradrenalin-Freisetzung aus dem Herzen. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 242, 214–227 (1961).

    CAS  Google Scholar 

  • Lindmar, R., Muscholl, E.: Die Wirkung von Pharmaka auf die Elimination von Nor-adrenalin aus der Perfusionsflüssigkeit und die Noradrenalinaufnahme in das isolierte Herz. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 247, 469–492 (1964).

    CAS  Google Scholar 

  • Lindmar, R., Muscholl, E.: Die Verstärkung der Noradrenalin-Wirkung durch Tyramin. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 251, 122–133 (1965).

    Google Scholar 

  • Lindmar, R., Muscholl, E.: Der Einfluß von Pharmaka auf die Aufnahme von Guanethidin in das Herz. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 253, 67 (1966).

    Google Scholar 

  • Lundborg, P.: Uptake of metaraminol by the adrenal medullary granules. Acta physiol. scand. 67, 423–429 (1966).

    PubMed  CAS  Google Scholar 

  • Maengwyn-Davies, G.D., Koppanyi, T.: Cocaine tachyphylaxis and effects on indirectly-acting sympathomimetic drugs in the rabbit aortic strip and in splenic tissue. J. Pharmacol, exp. Ther. 154, 481–492 (1966).

    CAS  Google Scholar 

  • Maickel, R.P., Beaven, M.A., Brodie, B.B.: Implications of uptake and storage of nor-epinephrine by sympathetic nerve endings. Life Sci. 2, 953–958 (1963).

    CAS  Google Scholar 

  • Maj, J., Langwinski, R.: Hypotensive action of tyramine in cats. J. Pharm. Pharmacol. 18, 820–821 (1966).

    PubMed  CAS  Google Scholar 

  • Marley, E.: Action of some sympathomimetic amines on the cat’s iris, in situ or isolated. J. Physiol. (Lond.) 162, 193–211 (1962).

    CAS  Google Scholar 

  • Maxwell, R.A., Plummer, A. J., Povalski, H., Schneider, F., Coombs, H.: A comparison of some of the cardiovascular actions of methylphenidate and cocaine. J. Pharmacol, exp. Ther. 126, 250–257 (1959a).

    CAS  Google Scholar 

  • Maxwell, R.A., Plummer, A. J., Povalski, H., Schneider, F., Coombs, H., Povalski, H., Plummer, A.J.: A differential effect of reserpine on the pressor amine activity and its relationship to other agents producing this effect. J. Pharmacol, exp. Ther. 125, 178–183 (1959b).

    CAS  Google Scholar 

  • Maxwell, R.A., Plummer, A. J., Povalski, H., Schneider, F., Coombs, H., Povalski, H., Plummer, A.J., Wastila, W.B., Eckhardt, S.B.: Some factors determining the response of rabbit aortic strips to dl-norepinephrine–7-H3 hydrochloride and the influence of cocaine, guanethidine and methylphenidate on these factors. J. Pharmacol, exp. Ther. 151, 253–261 (1966).

    CAS  Google Scholar 

  • Murnaghan, M.F.: Potentiation of tyramine responses by nor-sympathomimetic amines in the reserpine-pretreated cat. Arch. int. Pharmacodyn. 155, 332–355 (1965).

    CAS  Google Scholar 

  • Musacchio, J.M., Bhagat, B., Jackson, C. J., Kopin, I. J.: The effect of disulfiram on the restoration of the response to tyramine by dopamine and α-methyl-DOPA in the reserpine-treated cat. J. Pharmacol, exp. Ther. 152, 293–297 (1966).

    CAS  Google Scholar 

  • Musacchio, J.M., Bhagat, B., Jackson, C. J., Kopin, I. J., Kopin, I. J., Weise, V.K.: Subcellular distribution of some sympathomimetic amines and their beta-hydroxylated derivatives in the rat heart. J. Pharmacol, exp. Ther. 148, 22–28 (1965).

    CAS  Google Scholar 

  • Muscholl, E., Sprenger, E.: Vergleichende Untersuchungen der Blutdruckwirkung, Aufnahme und Speicherung von Dihydroxyephedrin (a-Methyladrenalin) und Dihydroxy-pseudoephedrin. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 254, 109–124 (1966).

    CAS  Google Scholar 

  • Muscholl, E., Sprenger, E., Weber, E.: Die Hemmung der Aufnahme von α-methylnoradrenalin in das Herz durch sympathomimetische Amine. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 252, 134–143 (1965).

    CAS  Google Scholar 

  • Muskus, A. J.: Evidence for different sites of action of reserpine and guanethidine. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 248, 498–513 (1964).

    CAS  Google Scholar 

  • Nash, C.W., Wolff, S.A., Ferguson, B.A.: Release of tritiated noradrenaline from perfused rat hearts by sympathomimetic amines. Canad. J. Physiol. Pharmacol. 46, 35–42 (1968).

    CAS  Google Scholar 

  • Paasonen, M.K., Krayer, O: Effect of reserpine upon the mammalian heart. Fed. Proc. 16, 326 (1957).

    Google Scholar 

  • Paasonen, M.K., Krayer, O: The release of norepinephrine from the mammalian heart by reserpine. J. Pharmacol. exp. Ther. 123, 153–160 (1958).

    PubMed  CAS  Google Scholar 

  • Patil, P.N., Jacobowitz, D.: Steric aspects of adrenergic drugs. IX. Pharmacologic and histochemical studies on isomers of cobefrin (a-methylnorepinephrine). J. Pharmacol, exp. Ther. 161, 279–295 (1968).

    CAS  Google Scholar 

  • Patil, P.N., Jacobowitz, D., Lapidus, J.B., Tye, A.: Steric aspects of adrenergic drugs. I. Comparative effects of DL isomers and desoxy derivatives. J. Pharmacol, exp. Ther. 155, 1–12 (1967a).

    CAS  Google Scholar 

  • Patil, P.N., Jacobowitz, D., Lapidus, J.B., Tye, A., Campbell, D., Tye, A.: Steric aspects of adrenergic drugs. II. Effects of DL isomers and desoxy derivatives on the reserpine-pretreated vas deferens. J. Pharmacol, exp. Ther. 155, 13–23 (1967b).

    CAS  Google Scholar 

  • Pluchino, S.: Direct and indirect effects of 5-hydroxytryptamine and tyramine on cat smooth muscle. Naunyn-Schmiedeberg’s Arch. Pharmak. in press (1972).

    Google Scholar 

  • Pluchino, S., Muskus, A. J., Pluchino, R.: The mechanism of action of guanethidine on the isolated mammalian heart. J. Pharmacol, exp. Ther. 170, 44–49 (1969).

    CAS  Google Scholar 

  • Pluchino, S., Muskus, A. J., Pluchino, R., Trendelenburg, U.: The influence of denervation and of decentralization on the alpha and beta effects of isoproterenol on the nictitating membrane of the pithed cat. J. Pharmacol. exp. Ther. 163, 257–265 (1968).

    PubMed  CAS  Google Scholar 

  • Poch, G.R., Kopin, I.J.: The role of octopamine in tachyphylaxis to tyramine. Biochem. Pharmacol. 15, 210–212 (1966).

    PubMed  CAS  Google Scholar 

  • Pratesi, P., Blaschko, H.: Specificity of amine oxidase for optically active substrates and inhibitors. Brit. J. Pharmacol. 14, 256–260 (1959).

    PubMed  CAS  Google Scholar 

  • Ross, S.B., Renyi, A.L.: Uptake of tritiated tyramine and (-F)-amphetamine by mouse heart slices. J. Pharm. Pharmacol. 18, 756–757 (1966a).

    PubMed  CAS  Google Scholar 

  • Ross, S.B., Renyi, A.L.: Uptake of some tritiated sympathomimetic amines by mouse brain cortex slices in vitro. Acta Pharmacol. (Kbh.) 24, 297–309 (1966b).

    CAS  Google Scholar 

  • Ross, S.B., Renyi, A.L., Brunfelter, B.: Cocaine-sensitive uptake of sympathomimetic amines in nerve tissue. J. Pharm. Pharmacol. 20, 283–288 (1968).

    PubMed  CAS  Google Scholar 

  • Salzmann, R., Pacha, W., Taeschler, M., Weidmann, H.: The effect of ergotamine on humoral and neuronal actions in the nictitating membrane and the spleen of the cat. Naunyn-Schmiedeberg’s Arch. exp. Pathol. Pharmakol. 261, 360–378 (1968).

    CAS  Google Scholar 

  • Schmidt, J.L., Fleming, W.W.: The structure of sympathomimetics as related to reserpine induced sensitivity changes in the rabbit ileum. J. Pharmacol, exp. Ther. 139, 230–237 (1963).

    CAS  Google Scholar 

  • Schmitt, H., Schmitt, H.: Modification des effects des amines sympathicomimétiques sur la pression artérielle et la membrane nictitante par la réserpine. Arch. int. Pharmacodyn. 125, 30–47 (1960).

    CAS  Google Scholar 

  • Smith, C. B.: The role of monoaminoxidase in the intraneuronal metabolism of norepinephrine released by indirectly-acting sympathomimetic amines or by adrenergic nerve stimulation. J. Pharmacol, exp. Ther. 151, 207–220 (1966).

    CAS  Google Scholar 

  • Steinberg, M.I., Smith, C.B.: Effects of desmethylimipramine and cocaine on the uptake, retention and metabolism of H3-tyramine in rat brain slices. J. Pharmacol, exp. Ther. 173, 176–192 (1970).

    CAS  Google Scholar 

  • Suarne, L., Von Euler, U.S.: Stereospecificity of amine uptake mechanism in nerve granules. J. Pharmacol, exp. Ther. 150, 335–340 (1966).

    Google Scholar 

  • Stone, C.A., Stavorski, J.M., Ludden, C.T., Wenger, H.C., Torchiana, M.L.: Some direct and indirect sympathomimetic actions of metaraminol. Arch. int. Pharmacodyn. 161, 49–60 (1966).

    CAS  Google Scholar 

  • Stromblad, B.C.R., Nickerson, M.: Accumulation of epinephrine and norepinephrine by some rat tissues. J. Pharmacol, exp. Ther. 134, 154–159 (1961).

    CAS  Google Scholar 

  • Su, C., Bevan, J.A.: Blockade of the nicotine-induced norepinephrine release by cocaine, phenoxybenzamine and desipramine. J. Pharmacol, exp. Ther. 175, 533–540 (1970).

    CAS  Google Scholar 

  • Tainter, M.L., Chang, D.K.: The antagonism of the pressor action of tyramine by cocaine. J. Pharmacol, exp. Ther. 30, 193–207 (1927).

    CAS  Google Scholar 

  • Thoa, N.B., Eccleston, D., Axelrod, J.: The accumulation of C14-serotonin in the guinea-pig vas deferens. J. Pharmacol, exp. Ther. 169, 68–73 (1969).

    CAS  Google Scholar 

  • Thoenen, H., Hurlimann, A., Haefely, W.: Mechanism of amphetamine accumulation in the isolated perfused heart of the rat. J. Pharm. Pharmacol. 20, 1–11 (1968).

    PubMed  CAS  Google Scholar 

  • Thoenen, H., Hurlimann, A., Haefely, W.: Cation dependence of the noradrenaline-releasing action of tyramine. Europ. J. Pharmacol. 6, 29–37 (1969).

    CAS  Google Scholar 

  • Thoenen, H., Hurlimann, A., Haefely, W., Tranzer, J.P.: Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 261, 271–288 (1968).

    CAS  Google Scholar 

  • Trendelenburg, U.: The action of histamine and 5-hydroxytryptamine on isolated mammalian atria. J. Pharmacol, exp. Ther. 130, 450–460 (I960).

    Google Scholar 

  • Trendelenburg, U.: Supersensitivity and subsensitivity to sympathomimetic amines. Pharmacol. Rev. 15, 225–276 (1963).

    PubMed  CAS  Google Scholar 

  • Trendelenburg, U.: The effect of cocaine on the pacemaker of isolated guinea-pig atria. J. Pharmacol, exp. Ther. 161, 222–231 (1968).

    CAS  Google Scholar 

  • Trendelenburg, U., Crout, J. R.: The norepinephrine stores of isolated atria of guinea pigs pretreated with reserpine. J. Pharmacol, exp. Ther. 145, 151–161 (1964).

    CAS  Google Scholar 

  • Trendelenburg, U., Crout, J. R., Draskoczy, P.R., Pluchino, S.: The density of adrenergic innervation of the cat’s nictitating membrane as a factor influencing the sensitivity of the isolated preparation to 1-norepinephrine. J. Pharmacol, exp. Ther. 166, 14–25 (1969).

    CAS  Google Scholar 

  • Trendelenburg, U., Crout, J. R., Draskoczy, P.R., Pluchino, S., Gomez Alonso De La Sierra, B., Muskus, A.: Modification by reserpine of the response of the atrial pacemaker to sympathomimetic amines. J. Pharmacol, exp. Ther. 141, 301 to 309 (1963).

    Google Scholar 

  • Trendelenburg, U., Crout, J. R., Draskoczy, P.R., Pluchino, S., Gomez Alonso De La Sierra, B., Muskus, A., Hohn, D., Graefe, K.H., Pluchino, S.: The influence of block of catechol-O-methyl transferase on the sensitivity of isolated organs to catecholamines. Naunyn-Schmiedeberg’s Arch. Pharmak. 271, 59–92 (1971).

    CAS  Google Scholar 

  • Trendelenburg, U., Crout, J. R., Draskoczy, P.R., Pluchino, S., Gomez Alonso De La Sierra, B., Muskus, A., Hohn, D., Graefe, K.H., Pluchino, S., Maxwell, R.A., Pluchino, S.: The importance of the intraneuronal uptake in the cat’s nictitating membrane as assessed with methoxamine, a sympathomimetic amine which is not taken up by adrenergic nerves. J. Pharmacol, exp. Ther. 172, 91–99 (1970).

    CAS  Google Scholar 

  • Trendelenburg, U., Muskus, A., Fleming, W. W., Gomez Alonso De La Sierra, B.: Modi-fication by reserpine of the action of sympathomimetic amines in spinal cats; a classification of sympathomimetic amines. J. Pharmacol, exp. Ther. 138, 170–180 (1962a).

    CAS  Google Scholar 

  • Trendelenburg, U., Muskus, A., Fleming, W. W., Gomez Alonso De La Sierra, B.: Effect of cocaine, denervation and decentralization on the response of the nictitating membrane to various sympathomimetic amines. J. Pharmacol, exp. Ther. 138, 181–193 (1962b).

    CAS  Google Scholar 

  • Tsai, T.H., Fleming, W.W.: Sympathomimetic actions of monoamine oxidase inhibitors in the isolated nictitating membrane of the cat. Biochem. Pharmacol. 14, 369–371 (1965).

    PubMed  CAS  Google Scholar 

  • Tsai, T.H., Fleming, W.W., Langer, S.Z., Trendelenburg, U.: Effects of dopamine and α-methyl-dopamine on smooth muscle and on the cardiac pacemaker. J. Pharmacol, exp. Ther. 156, 310–324 (1967).

    CAS  Google Scholar 

  • Tsai, T.H., Fleming, W.W., Langer, S.Z., Trendelenburg, U., Wendt, R.L., Mcgrath, W.R.: The negative chronotropic effect of tyramine on isolated guinea-pig atria. J. Pharmacol, exp. Ther. 168, 290–294 (1969).

    CAS  Google Scholar 

  • Tye, A., Baldesberger, R., Lapidus, J.B., Patil, P.N.: Steric aspects of adrenergic drugs. VI. Beta adrenergic effects of ephedrine isomers. J. Pharmacol, exp. Ther. 157, 356–362 (1967a).

    CAS  Google Scholar 

  • Tye, A., Baldesberger, R., Lapidus, J.B., Patil, P.N., Patil, P.N., Lapidus, J.B.: Steric aspects of adrenergic drugs. III. Sensitization by cocaine to isomers of sympathomimetic amines. J. Pharmacol, exp. Ther. 155, 24–30 (1967b).

    CAS  Google Scholar 

  • Urquilla, P.R., Stitzel, R.E., Fleming, W.W.: The antagonism of phentolamine against exogenously administered and endogenously released norepinephrine in rabbit aortic strips. J. Pharmacol, exp. Ther. 172, 310–319 (1970).

    CAS  Google Scholar 

  • Valdecasas, F.G., Salva, J. A., Cuenca, E.: Effect of reserpine on the blood pressure of the spinal cat treated with inhibitors of amino-oxydase. Arzneimittel-Forsch. 8, 655–656 (1958).

    CAS  Google Scholar 

  • Vanderipe, D.R., Kahn, J.B.: The mechanism of the vasodepressor response to tyramine in dogs. J. Pharmacol, exp. Ther. 145, 292–298 (1964).

    CAS  Google Scholar 

  • Van Orden, L.S. III, Bensch, K.G., Langer, S.Z., Trendelenburg, U.: Histochemical and fine structural aspects of the onset of denervation supersensitivity in the nictitating membrane of the spinal cat. J. Pharmacol, exp. Ther. 157, 274–283 (1967).

    Google Scholar 

  • Varma, D.R., Gillis, R.A., Benfey, B.G.: Reserpine as an antagonist of tyramine. J. Pharmacol, exp. Ther. 144, 181–185 (1964).

    CAS  Google Scholar 

  • Wakade, A.R., Cervoni, P., Furchgott, R.F.: Tyramine tachyphylaxis and the interaction of tyramine and bretylium in the guinea-pig isolated left atrium. J. Pharmacol, exp. Ther. (in press).

    Google Scholar 

  • Waldeck, B.: On the interaction of threo–3H-a-methylnoradrenaline with the uptake and storage mechanisms of the adrenergic neuron. Europ. J. Pharmacol. 2, 208–213 (1967).

    CAS  Google Scholar 

  • Walsh, M. J., Hollander, P.B., Truitt, E.B., Jr.: Sympathomimetic effects of acetaldehyde on the electrical and contractile characteristics of isolated left atria of guinea pigs. J. Pharmacol, exp. Ther. 167, 173–186 (1969).

    CAS  Google Scholar 

  • Weiner, N., Draskoczy, P.R., Burack, W.R.: The ability of tyramine to liberate catecholamines in vivo. J. Pharmacol, exp. Ther. 137, 47–55 (1962).

    CAS  Google Scholar 

  • Westfall, D.P., Fleming, W.W.: The sensitivity of the guinea-pig pacemaker to norepinephrine and calcium after pretreatment with reserpine. J. Pharmacol, exp. Ther. 164, 259–269 (1968).

    CAS  Google Scholar 

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  1. U. Trendelenburg
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  1. University Department of Pharmacology, South Parks Road, Oxford, OX1 3QT, Great Britain

    H. Blaschko

  2. Abt. für Neuropharmakologie, Pharmakologisches Institut der Universität, Obere Zahlbacher Str. 67, D-65, Mainz, Germany

    E. Muscholl

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Trendelenburg, U. (1972). Classification of Sympathomimetic Amines. In: Blaschko, H., Muscholl, E. (eds) Catecholamines. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65249-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-65249-3_10

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