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The Metabolism of Analogs of Endogenous Substrates: Wider Application of a Limited Concept

  • H. George Mandel
Part of the Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie book series (HEP, volume 28 / 2)

Abstract

Substrate analogs may be defined as compounds which bear a close chemical and/or physical resemblance to a constituent of normal tissue and which may replace the latter in one or more of its normal reactions, usually leading to a metabolic block. The substrate analogs, or antimetabolites, usually compete with the natural substrate at the same site on an enzyme. Actually, only a portion of the antimetabolite molecule must be analogous for competition.

Keywords

Xanthine Oxidase Endogenous Substrate Cytosine Arabinoside Substrate Analog Thymidylate Synthetase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin · Heidelberg 1971

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  • H. George Mandel

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