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Enzymatic N-, O-, and S-Dealkylation of Foreign Compounds by Hepatic Microsomes

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Concepts in Biochemical Pharmacology

Abstract

A wide variety of drugs and other foreign compounds are dealkylated by enzyme systems localized in the microsomal fraction of liver and to lesser degrees, in kidney, lung, and other organs including placenta. During an investigation of the metabolism of a series of chemical carcinogens, Miller et al. (1952) observed that after the intraperitoneal administration of 3′-methyl-4-dimethyl-14C-amino-azobenzene to rats, a significant amount of 14CO2 was recoverable from the expired air. Subsequent work (Mueller and Miller, 1953) revealed the presence of an enzyme system in rat liver which catalyzed the demethylation of a number of secondary amines with the liberation of formaldehyde and primary amine.

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Gram, T.E. (1971). Enzymatic N-, O-, and S-Dealkylation of Foreign Compounds by Hepatic Microsomes. In: Brodie, B.B., Gillette, J.R., Ackerman, H.S. (eds) Concepts in Biochemical Pharmacology. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 28 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65177-9_20

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