The Abortive Transformation of Monkey Kidney Cells by SV40
In the model systems which are used experimentally to study the development of malignancy, viral oncogenesis has the advantage that a genetic entity induces specific cellular alterations. These induced alterations are called “transformation”. Viral transformation is characterized by the acquisition of growth and morphological changes, a new nuclear tumor antigen (T antigen) and surface antigens which are specific for the transforming virus, and, where it can be measured, an increased resistance to the inducing agent . Current interest has been focused on whether the process is reversible.
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