Granulocytic Chalone and Leukaemia
Granulocytic chalone was extracted from granulocytes of men, cattle and rats as well as from subcutaneous chloromas of rats and leukaemic human cells (chronic myeloic leukaemia) and concentrated by ultrafiltration. The chalone inhibits DNS-synthesis in normal and leukaemic granulocytes in a tissue- but not species-specific form. Generalized leukaemia (ehloroleukaemia of the rat) can be completely and permanently cured by repeated injections of chalone. In all animals thus treated it was possible to distinctly extend the survival time; with 9 out of 40 rats the leukaemia was made to disappear permanently. Possibilities of application for the treatment of human leukaemia are discussed.
The substance of the lecture is fully covered by the following two articles