Physical Stability of the Microcirculation

  • T. Azuma
  • S. Oka
Conference paper


Since 1951, BURTON and his colleagues have discussed physical equilibrium of vascular walls by utilizing the Law of Laplace and proposed the concept of critical closing pressure (1–4). These results have been quoted in several standard textbooks of physiology. The purpose of the present paper is to discuss critically the validity of applying the Laplacian equation to thick walled blood vessels on the basis of our general equation (5).


Laplacian Equation Small Artery Blood Vessel Wall Active Tension Transmural Pressure 
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    BURTON, A.C.: Am. J. Physiol. 164, 319 (1951).PubMedGoogle Scholar
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    NICHOL, J., GIRLING, F., JERRARD, W., CLAXTON, E.B., BURTON, A.C.: Am. J. Physiol. 164, 330 (1951).PubMedGoogle Scholar
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    BURTON, A.C., STINSON, R.H.: J. Physiol. 153, 290 (1960).PubMedGoogle Scholar
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    BURTON, A.C., STINSON, R.H.: In Section 2: Circulation, vol. I. 85 (1962), Amer. Physiol. Soc., Washington, D.C.Google Scholar
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    OKA, S., AZUMA, T.: Theoretical studies in blood vessel hemorheology, in press.Google Scholar
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    HARDUNG, V.: Helv. physiol. acta 10, 482 (1952).Google Scholar
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    LAWTON, R.W.: Circ. Res. 2, 344 (1954).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1971

Authors and Affiliations

  • T. Azuma
    • 1
  • S. Oka
    • 2
  1. 1.Department of PhysiologyShinshu University Medical SchoolMatsumotoJapan
  2. 2.Department of PhysicsTokyo Metropolitan UniversityTokyoJapan

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