Interpretation of Antimalarial Activity in Terms of Regression Analyses, Molecular Orbital Calculations, and Theory of DNA-Drug Binding

  • George E. Bass
  • Donna R. Hudson
  • Jane E. Parker
  • William P. Purcell
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 2)


In 1965 a model to account for the antimalarial activity of chloroquine and its congeners was proposed by O’Brien and Hahn (O’Brien and Hahn, 1965) (see Fig. 1).


Partition Coefficient Antimalarial Activity Molecular Orbital Calculation Quinoline Ring Substituent Constant 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1971

Authors and Affiliations

  • George E. Bass
  • Donna R. Hudson
  • Jane E. Parker
  • William P. Purcell

There are no affiliations available

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