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Effects of Chloroquine and Some Related Compounds on Aminoacylation of Transfer Ribonucleic Acids

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Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 2))

Abstract

Transfer RNA presents certain theoretical advantages over DNA for studies of selective effects of ligand binding. The number of unique ligand-binding sites in DNA is limited by the rarity of unusual bases and by the regular secondary structure. More-over, many intercalating drugs, such as chloroquine (O’Brien, Allison, and Hahn, 1966; Sutherland and Sutherland, 1969) bind rather nonspecifically to both purine and pyrimidine residues in DNA [Cohen and Yielding, 1965 (1); Blodgett and Yielding, 1968]. Finally, the enzymes most used in studies of ligand-treated DNA, for example DNA and RNA polymerases [Cohen and Yielding, 1965 (2); O’Brien, Olenick and Hahn, 1966), in order to act must move along DNA for hundreds of base pairs with consequently increased chance for collision with ligands and thus inhibition.

Markle Scholar in Academic Medicine. Supported by Grant NIH-AM-09001-06 from the National Institutes of Health, U.S. Public Health Service and Grant PRA-21 from the American Cancer Society.

Fellow of the Life Insurance Medical Research Fund.

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Authors
  1. Karl H. Muench
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  2. Michael Deldin
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  3. Julio C. Pita Jr.
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Editors and Affiliations

  1. Department of Molecular Biology, Walter Reed Army Institute of Research, Washington, D.C., 20012, USA

    Fred E. Hahn

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Muench, K.H., Deldin, M., Pita, J.C. (1971). Effects of Chloroquine and Some Related Compounds on Aminoacylation of Transfer Ribonucleic Acids. In: Hahn, F.E. (eds) Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action. Progress in Molecular and Subcellular Biology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65141-0_10

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  • DOI: https://doi.org/10.1007/978-3-642-65141-0_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65143-4

  • Online ISBN: 978-3-642-65141-0

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