Abstract
In the latest years, the more and more intense quest for new pharmacologically active substances prompted the scientists not only to synthesize thousands of new compounds, but also to study more deeply several classes of natural substances, especially those obtainable from plants.
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References
N. R. Farnsworth, J. Pharm. Sci. 55, 225 (1966)
T. A. Geissman, Annual. Rev. Pharmacol. 4, 305 (1964)
J. L. Hartwell, Adv. Pharm. 7, 117 (1969)
R. Hardman, Phytochemistry 8, 1319 (1969)
G. C. Cotzias, M. H. van Woert, and L. M. Schiffee, New England J. Med. 276, 374 (1967)
see: J. A.M. A. 209, 1358 (1969)
Th. Wieland, Ann. 564, 152 (1949)
Th. Wieland and H. W. Schnabel, Ann. 657, 218 (1962)
Th. Wieland, Pure Appl. Chem. 9, 145 (1964)
Th. Wieland and U. Gebert, Ann. 700, 157 (1966)
J. Drenth, J. N. Jansonius, R. Koekoek, H. M. Swen, and B. G. Wolthers, Nature (London) 218, 929 (1968)
S. S. Husain and G. Lowe, Biochem. J. 108, 855, 961 (1968)
S. S. Husain and G. Lowe, Chem. Comm. 1968, 1387
G. B. Marini-Bettòlo, P. U. Angeletti, M. L. Salvi, L. Tentori, and G. Vivaldi, Gazz. Chim. Ital. 93, 1239 (1963)
G. Porcelli and G. B. Marini-Bettòlo, Ann. Chim. 55, 792 (1965)
L. Panizzi and O. Scarpati, Gazz. Chim. Ital. 84, 792 (1954)
L. Panizzi and O. Scarpati, Gazz. Chim. Ital. 95, 71 (1965)
M. Lefranc, J. Pharm. Chim. 9, 81 (1869)
F. Angelico, Gazz. Chim. Ital. 36, 636 (1906)
H. Wunschendorff and P. Braudel, Bull. Soc. Chim. Biol. 13, 758 (1931)
T. AjeHo, . 63, 99, 289 (1933)
F. Piozzi, A. Quilico, C. Fuganti, T. Ajelio, and V. Sprio, Gazz. Chim. Ital. 97, 935 (1967)
R. Santi, Ricerca Sci. 26, 2536 (1956)
F. Pocchiari and V. Silano, Biochem. J. 107, 305 (1968)
Z. Valenta, S. Papadopoulos, and C. Podesva, Tetrahedron 15, 100 (1961)
Z. Valenta, A. H. Gray, D. E. Orr, S. Papadopoulos, and C. Podesva, Tetrahedron 18, 1433 (1962)
R. M. Carman and A. D. Ward, Australian J. Chem. 15, 807 (1962)
J. Moron and J. Polonsky, Tetrahedron Letters 10, 385 (1968)
C. G. Casinovi, V. Bellavita, G. Grandolini, and P. Ceccherelli, Tetrahedron Letters 7, 2273 (1965)
T. A. Geissman, W. Stocklin, and C. G. Casinovi, Tetrahedron Letters 1970 in press
C. G. Casinovi and G. Grandolini, Atti Accad. Nazi. Lincei Rend. Classe Sci. Fis. Mat. Nat., Ser. VIII, 35, 348 (1963)
C. G. Casinovi, P. Ceccherelli, G. Grandolini, and V. Bellavita, Tetrahedron Letters 6, 3991 (1964)
J. Polonsky and J. L. Fourrey, Tetrahedron Letters 6, 3983 (1964)
I. De Carneri and C. G. Casinovi, Parassitologia 10, 215 (1968)
J. Polonsky, CI. Fouquey, and A. Gandemer, Bull. Soc. Chim. France 1964, 1827
G. Kartha, D.J. Haas, H. M. Schaffer, and K. K. Kaista, Nature (London) 202, 389 (1964)
A. C. Kuckler, S. Kuna, C. W. Mushett, R. H. Silber, R. B. Stebbins, H. C. Stoerk, R. N. Arison, F. Cuchie, and C. M. Malanga, Arch, intern. Pharmacodyn. 114, 307 (1958)
C. G. Casinovi, P. Ceccherelli, and G. Grandolini, Ann. 1st. Super. Sanità 2, 414 (1966)
C. G. Casinovi, G. Grandolini, G. B. Marini-Bettblo, and V. Bellavita, Ann. Chim. 59, 230 (1969)
Le-Van-Thoi and Nguyen-Ngoc-Suong, J. Org. Chem. 35, 1104 (1970)
M. A. Leboeuf, A. Cave, and R. Goutarel, C. R. Acad. Sci. 259, 3401 (1964)
D. H. G. Crout, C. H. Hassail, and T. L. Jones, J. Chem. Soc. 1964, 2187
S. M. Kupcha, R. W. Doskotch, A. T. McPhail, G.A.Sim, and J. A. Saenz Renauld, J. Am. Chem. Soc. 65, 5806 (1965)
S. Corsano, G. Piane at elli, and L. Panizzi, G. zz. Chim. Ital. 99, 915 (1969)
K. Weinges, Angew. Chemie 74, 514 (1962)
D. Nisi and L. Panizzi, Gazz. Chim. Ital. 96, 803 (1966)
F. Delle Monache, I. Leoncio d’Albuquerque, F. Ferrari, and G. B. Marini-Bettòlo, Tetrahedron Letters 9, 4211 (1967)
F. Delle Monache, I. Leoncio d’Albuquerque, F. Ferrari, and Marini-Bettolo, G. B. Ann. Chim. 57, 964 (1967)
F. Delle Monache, I. Leoncio d’Alburquerque, F. Ferrari, and G. B. Marini-Bettblo, Ann. Chim. 57, 1364 (1967)
J. R. Cole and L. Buchalter, J. Pharm. Soc. 54, 1376 (1965)
F. Delle Monache, F. Ferrari, I. Leoncio d’Albuquerque, and G. B. Marini-Bettolo, Farmaco (Ed. Sci.) 25, 96 (1970)
L. Panizzi, M. L. Scarpati, and G. Oriente, Gazz. Chim. Ital. 90, 1444 (1960)
O. Gonçalves de Lima, L. Gonzaga de Prado Filho, Revista Institut. 2, 19 (1959)
I. Leoncio d’Albuquerque, C. Galeffi, C. G. Casinovi, and G. B. Marini-Bettolo, Gazz. Chim. Ital. 94, 287 (1964)
C. Galeffi, C. G. Casinovi, and G.B. Marini-Bettblo, Gazz. Chim. Ital. 95, 95 (1965)
S. M. Kupchan, Trans. New York Acad. Sci. 32, 85 (1970)
J.L. Hartwell, Lloydia 32, 78 247 (1969)
S. M. Kupchan, Y. Aynehchi, J. M. Cassady, A. T. McPhail, G.A.Sim, H. K. Schnoes, and A. L. Burlingame, J. Am. Chem. Soc. 88, 3674 (1966)
S. M. Kupchan, Y. Aynehchi, J.M. Cassady, H. K. Schnoes, and A. L. Burlingame, J. Org. Chem. 34, 3876 (1969)
S. M. Kupchan, R.J. Hemingway, D.Werner, A. Karim, A. J. McPhail, and G.A. Sim, J. Am. Chem. Soc. 90, 3596 (1968)
S. M. Kupchan, R. J. Hemingway, D. Werner, and A. Karim, J. Org. Chem. 34, 3903 (1969)
S. M. Kupchan, J.C. Hemingway, J. M. Cassady, J.R. Knox, A. J. McPhail, and G.A. Sim, J. Am. Chem. Soc. 89, 465 (1967)
S. M. Kupchan, J. M. Cassady, J.Bailey, and J. R. Knox, J. Pharm. Sci. 54, 1703 (1965)
S. M. Kupchan, J. M. Cassady, J.E. Kelsey, H. K. Schnoes, D.H. Smith, and A. L. Burlingame, J. Am. Chem. Soc. 88, 5292 (1966)
S. M. Kupchan, D. C. Fessler, M. A. Eakin, and T. J. Giacobbe, Science 168, 376 (1970)
C. J. Cavallito and T. A. Haskell, J. Am. Chem. Soc. 67, 1991 (1945)
G. B. Marini-Bettblo and E. Del Pianto, Comm. Pont. Acad. Sci. 11, 33 (1947)
G. Di Modica and S. Tira, Gazz. Chim. Ital. 86, 234 (1956)
O. Isler, H.Mayer, R. Riiegg, and J. Würsch, in: International Symposium on Recent Advances in Research on Vitamins K and related Quinones; Vitamins and Hormones 24, 331 (1966)
G. Doyle Daves, P. Friis, R. K. Olsen, and K. Folkers, in: International Symposium on Recent Advances in Research on Vitamins K and related Quinones; Vitamins and Hormones 24, 427 (1966)
E. R. Redfearn, in: International Symposium on Recent Advances in Research on Vitamins K and related Quinones; Vitamins and Hormones 24, 465 (1966)
F. L. Crane and M. D. Henninger, in: International Symposium on Recent Advances in Research on Vitamins K and related Quinones; Vitamins and Hormones 24, 489 (1966)
G. B. Marini-Bettòlo, C. G. Casinovi, C. Galeffi, and F. Delle Monache, Ann. Ist. Super. Sanità 2 327 (1966)
S. M. Kupchan, A. Karim, and C. Mareks, J. Am. Chem. Soc. 90, 5923 (1968)
C. G. Casinovi, J. A. Garbarino, and G. B. Marini-Bettblo, Rend. 1st. Super. Sanità. 23, 1073 (1960)
C. G. Casinovi, F.Delle Monache, G. B. Marini-Bettblo, J. A. Garbarino, and E. Bianchi, Gazz. Chim. Ital. 92, 479 (1962)
G. B. Marini-Bettòlo, Biogènesi di Sostanze Naturali; Acc. Nazi. Lincei 1964, 239; Conferenze, VII Corso Estivo di Chimica, Milano 1962
G. B. Marini-Bettòlo, Ann. 1st. Super. Sanità 4, 489 (1968)
C. Djerassi, J. P. Kutney, M. Shamma, J. N. Shoolery, and L. F. Johnson, Chem. & Ind. 1961, 210
T. Sakan, A. Fujino, F. Murai, Y. Butsugan, and A. Suzui, Bull. Chem. Soc. Japan 32, 315 (1958)
G. B. Marini- Bettòlo, C. G. Casinovi, and F. Delle Monache, Sci. Repts. Ist. Super. Sanità 2, 195 (1962)
C. G. Casinovi, J. A. Garbarino, and G. B. Marini-Bettblo, Chem. & Ind. 1961, 253
G. Adolphen, H.H. Appel, K.N. Overton, and D. C. Warnock, Tetrahedron 23, 3147 (1967)
G. Jones, H. H. Fales, and W. G. Wildman, Tetrahedron Letters 6, 397 (1963)
Y. Hammouda, M. Plat, and J. Le Men, Bull. Soc. Chim. France 1963, 2802
G. L. Gatti and M. Marotta, Ann. 1st. Super. Sanità 2, 29 (1962)
K. Torsell and K. Wahlberg, Tetrahedron Letters 8, 445 (1966)
F. N. Lahey and W. C. Thomas, Austral. J. Sci. Res. 2A, 423 (1949)
P. L. MacDonald and A. V. Robertson, Austral. J. Chem. 19, 275 (1966)
G. H. Svoboda, G. A. Poore, P.J. Simpson, and G. B. Boder, J. Pharm. Sci. 55, 758 (1966)
M. Kurono, Y. Nakadaira, S. Numa, K. Sasaki, and K. Nakanishi, Tetrahedron Letters, 5, 2153 (1963)
J. W. Harrison, R. M. Scrowston, and B. Lythgoe, J. Chem. Soc. 1966, 1933
T. R. Govindachari, B. R. Pai, and K. Nagarajan, J. Chem. Soc. 1954, 280
E. Geliert, T. R. Govindachari, M. V. Lakshmikantham, I. S. Ragade, R. Rudzats, and N. Viswanathan, J. Chem. Soc. 1962, 1008
J.D. Dutcher, J. Am. Chem. Soc. 68, 419 (1946)
M. Curcumelli-Rodostamo and M. Kulka, in: Manske, R. H. F. “The Alkaloids, chemistry and physiology”, New York and London, Acad. Press, vol. IX, p. 134 (1967)
S. M. Kupchan, T. H. Yang, G. S. Vasilikiotis, and M. H. Barnes, J. Am. Chem. Soc. 89, 3075 (1967)
F. Sandberg, K. Roos, K. J. Ryrberg, and K. Kristiansson, Tetrahedron Letters, 10, 6217 (1968)
G. B. Marini-Bettòlo, C. G. Casinovi, I. Gonzales Huerta, and M. Marotta, Rend. Ist. Super. Sanita 27, 75 (1964)
N. G. Bisset, Thesis submitted to the University of London, 1968
G. B. Marini-Bettòlo, F. Delle Monache, A. Gelabert de Brovetto, and F. Corio, J. Ass. Off. Anal. Chemists 51, 185 (1968)
A. Villar del Fresno, E. Miranda Delle Monache, C. Galeffi, M. A. Ciasca, and G. B. Marini-Bettòlo, Rend. Accad. Nazi. Lincei (8) 48, 46 (1970)
M. Koch, M. Plat, B. C. Das, and J. Le Men, Tetrahedron Letters 9, 3145 (1967)
F. Delle Monache, A. Poce Tucci, G. B. Marini-B ettblo, Tetrahedron Letters 11, 2009 (1969)
K. Bernhauer and W. Hofheinz, Fortschr. Chem. Org. Naturstoffe 26, 245 (1968)
L. J. Haynes, K.L. Stuart, D. H. R. Barton, D. S. Bhakuni, and G. W. Kirby, J. Chem. Soc. C 1966, 1676
B. Gilbert, M. E. A. Gilbert, M. M. De Oliveira, O. Ribeiro, E. Wenkert, B. Wickberg, U. Hollstein, and H. Rapoport, J. Am. Chem. Soc. 86, 694 (1964)
J. Schmutz, F. Hunziker, and R. Hirt, Helv. Chim. Acta 40, 1189 (1957)
G. B. Marini-Bettòlo and J. Schmutz, Helv. Chim. Acta 42, 2146 (1959)
P. Carvalho Ferreira, G. B. Marini-B ettblo, and J. Schmutz, Experientia 15, 179 (1959)
S. Goodwin, A.F. Smith, E. C. Horning, J. Am. Chem. Soc. 81, 1903 (1959)
M.E. Wall, M. C. Wani, C.E. Cook, K.H. Palmer, A. T. McPhail, and G. A. Sim, J. Am. Chem. Soc. 88, 3888 (1966)
J. Trojanek, Z. Kablicova, and K. Blaha, Chem. & Ind. 1965, 1261
G. H. Svoboda, N. Neuss, and M. Gorman, J. Am. Pharm. Assoc. (Sci. Ed.) 48, 659 (1959)
M. M. Janot, F. Laine, and R. Goutarel, Ann. Pharm. France 18, 673 (1960)
M. M. Janot, Q. Khuong-Huu, J. Yassi, and R. Goutarel, Bull. Soc. Chim. France 1964, 787
M. Truong-Ho, Q. Khuong-Huu, and R. Goutarel, Bull. Soc. Chim. France 1963, 594
K. G. Das and P. P. Pillay, J. Sci. Ind. Research (India) 13 B, 602 (1954)
H.R.Mahler, R. Gout ar el, Q. Khuong-Huu, and M. Truong-Ho, Biochemistry 5, 2177 (1966)
C. G. Casinovi, G. B. Marini-Bettòlo, M. Bonamico, A. Vaciago, Ric. Sci. 33, (II-A) 1028 (1963)
I. E. Schlitter, K. Heusler, and W. Friedrich, Helv. Chim. Acta 32, 2209 (1949)
D.R. Curtis, A. W. Duggan, D. Felix, and G. A. R. Johnston, Nature (London) 226, 1222 (1970)
D. H. Efron, B. Holmstedt, and N. S. Kline, ed. “Ethnopharmacologic Search for Psychoactive Drugs”, U. S. Public Health Serv. Publ. n. 1654, Washington D. C., 1967
C. H. Eugster, Helv. Chim. Acta 41, 886 (1958)
F. Kogl, H. C. Cox, and C. A. Salemink, Experientia 13, 137 (1957)
H. Fritz, A. R. Gagneux, R. Zbinden, C. H. Eugster, Tetrahedron Letters 7, 2075 (1965)
C. H. Eugster, G. F. R. Muller, and R. Good, Tetrahedron Letters 7, 1813 (1965)
M. Onda, H. Fukushima, and M. Akagawa, Chem. Pharm. Bull. (Tokyo) 12, 751 (1965)
P. G. Waser, in: Ethnopharmacologic Search for Psychoactive Drugs, D. H. Efron, B. Holmstedt, and N. S. Kline, ed. U. S. Public Health Serv., Publ. N. 1654, Washington D. C., 1967
R. Mechoulam, Science 168, 1159 (1970)
R. L. Hively, W. A. Mosher, and F. W. Hoffman, J. Am. Chem. Soc. 88, 1832 (1966)
A. Hoffmann, Austral. J. Pharm. 42, 7 (1961)
A. Hoffmann, R. B runner, H. Kobel, and A. Brack, Helv. Chim. Acta 40, 1358 (1957)
F. Arcamone, E. B. Chain, A. Ferretti, A. Minghetti, P. Pennella, A. Tonolo, and L. Vero, Proc. Roy. Soc. B 155, 26 (1961)
L. Bernardi, Chim. & Ind. (Milano) 51, 563 (1969)
F. A. Hochstein and A. M. Paradies, J. Am. Chem. Soc. 79, 5735 (1957)
G. B. Marini-Bettòlo, E. Biocca, C. Galeffi, F. Delle Monache, and E. C. Montalvo, Ann. Ist. Super. Sanità 3, 784 (1965)
E. Biocca, D. Bovet, C. Galeffi, and G. B. Marini-Bettbio, Atti Accad. Nazi. Lincei, Rend. Class. Sci. Fis. Mat. Nat. (8) 38, 34 (1965)
M.S. Fish, N.M.Johnson, and E. C. Horning, J. Am. Chem. Soc. 77, 5892 (1965)
I.I. Brekhman and I. V. Dardymov, Ann. Rev. Pharmacol. 9, 419 (1969)
H.Wagner, L. Hörhammer, and R. Münster, Arzneimittel-Forsch. (Drug Res.) 18, 688 (1968)
G.Hahn. H.D.Lehmann, M. Kürten, H. Uebel, and G. Vogel, Arzneimittel-Forsch. (Drug Res.) 18, 698 (1968)
A. Pelter and R. Hänsel, Tetrahedron Letters, 2911, (1968)
D.J. Abraham, S. Takagi, R. D. Rosenstein, R. Shiono, H.Wagner, L. H. Hammer, O. Seligmann, and N. R. Farnsworth, Tetrahedron Letters, 2675, (1970).
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Marini-Bettòlo, G.B. (1971). New Natural Substances of Pharmacological Interest. In: Wagner, H., Hörhammer, L. (eds) Pharmacognosy and Phytochemistry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65136-6_10
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