Abstract
In the last few years there have been many reports on the metabolic stimulation of lymphocytes by phytohaemagglutinin (PHA), an extract from Phaseolus vulgaris. PHA causes an increase of DNA, RNA, and protein synthesis in lymphocytes, stimulates their transformation to lymphoblasts, and induces them to undergo mitosis [1, 2, 8, 9, 12, 14]. The transformation of lymphocytes may be regarded as an example of gene activation in mammalian cells [10, 15].
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References
Bach, F., Hirschhorn, K.: Exp. Cell Res. 32, 592 (1963).
Bender, M. A., Prescott, D. M.: Exp. Cell Res. 27, 221 (1962).
Dische, Z.: Mikrochemie 8, 4 (1930).
Engelhardt, A.: Klin. Wschr. 42, 1141 (1964).
Frenster, J. H.,Allfrey, V. G.,Mirsky, A. E.: Proc. nat. Acad. Sci. (Wash.) 50, 1026 (1963).
Garvin, J. E.: J. exp. Med. 114, 51 (1961).
Harbers, E.,Lederer, B.,Sandritter, W., Spaar, U.: Virchows Arch. Abt. B Zellpath. 1, 98 (1968).
Hastings, J., Freedman, S., Rendon, O., Cooper, H. L., Hirschhorn, R.: Nature 192, 1214 (1961).
Havemann, K.: Z. ges. exp. Med. 151, 138 (1969).
Hirschhorn, R.,Troll, W., Brittinger, G., Weissmann, G.: Nature 222, 1247 (1969).
Imman, D. R., Cooper, E. H.: Acta haemat. (Basel) 33, 257 (1965).
McIntyre, O. R., Ebaugh, F. G., Jr.: Blood 19, 443 (1962).
Milner, G. R., Hayhoe, F. G. J.: Nature 218, 785 (1968).
Nowell, P. C.: Cancer Res. 20, 462 (1960).
Pogo, B. G. T., Allfrey, V. G., Mirsky, A. E.: Proc. nat. Acad. Sci. (Wash.) 55, 805 (1966).
Schneider, W. C.: J. biol. Chem. 161, 293 (1945).
Stanley, D. A., Frenster, J. H., Rigas, D. A.: J. Cell. Biol. 39, 129 a (1968).
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Drings, P. (1971). Changes of Euchromatin Content in Human Peripheral Lymphocytes under the Influence of Phytohaemagglutinin. In: Dumonde, D.C. (eds) The Role of Lymphocytes and Macrophages in the Immunological Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65133-5_14
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DOI: https://doi.org/10.1007/978-3-642-65133-5_14
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