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Metabolic Changes Induced by Alcohol pp 1–7Cite as

The Development of Alcohol Dehydrogenase and its Isoenzymes

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Abstract

During recent years ethanol has become a frequently used drug in obstetric management of premature uterine contractions leading to abortion or premature birth, due to its inhibitory effect on the release of oxytocin (LUUKKAINEN, VÄISTÖ, and JÄRVINEN, 1967). Since ethanol easily crosses the placental membranes and its oxidation has a marked effect on metabolic functions of the liver, we decided to study alcohol dehydrogenase (ADH) and alcohol oxidizing capacity in the developing mammalian liver. No previous information on this was available and we thought that it would be of general interest to have information concerning the capability of the fetus and the newborn to metabolize ethanol, since it was used so freely by the obstetricians during human pregnancy.

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References

  • Luukkainen, T., L. Väistö, and P. Järvinen: The effect of oral intake of ethyl alcohol on the activity of the pregnant human uterus. Acta Obst. Gynec. Scand. 46, 486 (1967).

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  • Pikkarainen, P.H. and N.C.R. Räihä: Development of alcohol dehydrogenase activity in the human liver. Pediat. Res. 1, 165 (1967).

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  • Pikkarainen, P. and N.C.R. Räihä: Changes in alcohol dehydrogenase isoenzyme pattern during development of human liver. Nature 222, 563 (1969).

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  • Räihä, N.C.R., M. Koskinen, and P. Pikkarainen: Developmental changes in alcohol dehydrogenase activity in rat and guinea-pig liver. Biochem. J. 103, 623 (1967).

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  • von Wartburg, J.P., J. Papenberg, and H. Aebi: An atypical human alcohol dehydrogenase. Canad. J. Biochem. 43, 889 (1965).

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Authors
  1. N. C. R. Räihä
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  2. P. H. Pikkarainen
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Editor information

Editors and Affiliations

  1. Medizinische Universitätsklinik Marburg, 355 Marburg/Lahn, Germany

    G. A. Martini  & Ch. Bode  & 

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© 1971 Springer-Verlag Berlin · Heidelberg

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Räihä, N.C.R., Pikkarainen, P.H. (1971). The Development of Alcohol Dehydrogenase and its Isoenzymes. In: Martini, G.A., Bode, C. (eds) Metabolic Changes Induced by Alcohol. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65131-1_1

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  • DOI: https://doi.org/10.1007/978-3-642-65131-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-05296-8

  • Online ISBN: 978-3-642-65131-1

  • eBook Packages: Springer Book Archive

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