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Der Einfluß von pH auf die Thyroxin-bindenden Proteine des Serums

Influence of pH on Thyroxine-binding Proteins in Blood Serum

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Frontiers of Nuclear Medicine/Aktuelle Nuklearmedizin

  • 36 Accesses

Summary

Artificial changes in the pH of the blood serum have been shown in vitro to affect the thyroxine-binding capacity of proteins; this is reduced above pH 8.5 and below pH 7.5. Intensive inhalation of O2 and CO2 by healthy subjects has produced discrete deviations in the thyroxine-binding proteins which may be observed even in vivo. Paper electrophoresis of 125I-labelled T4 incubated for one hour in serum buffered at pH 7.0 and 8.6 and labelled at two levels of radioactivity, showed that under more acid conditions more thyroxine binds preferentially to the albumin fraction. Thins, false positive tests of thyroid function may be obtained in patients whose disease produces raised pCO2, renal or metabolic acidosis and supraventricular arrhythmia.

“ … Such reports and the results of this study indicate the need for critical evaluation of the role of the various experimental techniques employed in attempting any physiologic assessment of this parameter of thyroid function …”

Hamolsky [16]

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Authors and Affiliations

  1. Isotopenlabor des Zentralen Strahleninstitutes des Kantonsspitals St. Gallen, Switzerland

    A. Bekier

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  1. Kantonsspital, CH-8006, Zurich, Switzerland

    Wolfgang Horst (Direktor der Universitätsklinik und Poliklinik für Nuklearmedizin und Radiotherapie) (Direktor der Universitätsklinik und Poliklinik für Nuklearmedizin und Radiotherapie)

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Bekier, A. (1971). Der Einfluß von pH auf die Thyroxin-bindenden Proteine des Serums. In: Horst, W. (eds) Frontiers of Nuclear Medicine/Aktuelle Nuklearmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65092-5_19

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  • DOI: https://doi.org/10.1007/978-3-642-65092-5_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65094-9

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