Interpretation of Radioisotope Renogram Changes During Acute Toxic Renal Insufficiency Due to Oxalic Acid

An Experimental Study
  • D. Pavel
Conference paper


In previous clinical works we emphasized the fact that isotope renogram might point to a certain alteration of the proximal tubular cell which could not be revealed by usual explorations [7, 12, 13]. We considered this alteration to be a disfunction of the cell which, though able to normally take up radio-Hippuran from peritubular blood, could not secrete it normally in the tubular lumen. We suggested the hypothesis that the cell passes through this stage both at the onset of insufficiency and during recovery.


Oxalic Acid Urine Output Tubular Cell Water Restriction Proximal Tubular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Becker, G.: Nierenfunktionsanalyse mit 131I-Hippuran (Theoretische and klinische Medizin, Bd. 40). Heidelberg: Alfred Huthig 1969.Google Scholar
  2. 2.
    Burke, G., Halko, H.: Scintillation camera renography in the study of prolonged renal transit time. Radiology 88, 704–712 (1967).PubMedGoogle Scholar
  3. 3.
    Dore, E. K., Taplin, G. V., Johnson, D. E.: Current interpretation of the sodium iodohippurate I131 renocystogram. J.A.M. A. 185, 925–932 (1963).PubMedGoogle Scholar
  4. 4.
    Forster, R. P., Copenhaver, J. H.: Intracellular accumulation as an active process in a mammalian renal transport system “in vitro”. Am. J. Physiol. 186, 167 (1956).PubMedGoogle Scholar
  5. 5.
    Foulkes, E. C., Miller, B. J.: Steps in PAH transport by kidney slices. Am. J. Physiol. 196, 86 (1959).PubMedGoogle Scholar
  6. 6.
    Frey, K. W., Hör, G., Heinze, G. H.: Radioisotopennephrographie bei der Nierentuberkulose. Nuclear Medizin 4, 249–262 (1965).Google Scholar
  7. 7.
    Gheorghescu, B., Pavel, D., Jovin, Gh.: Studiul modificărilor functiei renale în ciroze cu ajutorul renogramei izotopice. Medicina Int. (Bucharest) 19, 215–220 (1967).Google Scholar
  8. 8.
    Hundeshagen, H., Heimsoth, V., Graul, E. H., Hartmann, F.: Neue Aspekte in der Radionephrographie. Atompraxis 11 (August 1965).Google Scholar
  9. 9.
    Magnusson, G.: Kidney function studies with 131I-tagged sodium-o-iodohippurate. Acta med. scand., Suppl. 378 (1962).Google Scholar
  10. 10.
    Pabst, H. W.: Isotopendiagnostik von Nierenkrankheiten. Münch. med. Wschr. 34, 1581–1590 (1965).Google Scholar
  11. 11.
    Pavel, D., Chisiu, N., Oproiu, A.: Model experimental de studiu al functiei renale cu ajutorul nefrocistogramei izotopice la sobolan. Simpozion: Modelarea in biologie, Brasov, Romania, 1964.Google Scholar
  12. 12.
    Pavel, D., Gheorghescu, B., Herscovici, H., Cavulea, G., Lupu, Iréne, Jovin, Gh.: Objectivation à l’aide du néphrogramme isotopique d’une certaine étape de l’insuffisance tubulaire rénale. Acta urol. belg. 36, 59–67 (1968).Google Scholar
  13. 13.
    Pavel, D., Gheorghescu, B., Jovin, G., Rotarescu, G.: Le néphrogramme isotopique au cours de certaines formes d’insuffisance tubulaire rénale. Essai d’interpretation physiopathologique. J. Urol. Nephrol. 74, 645–654 (1968).Google Scholar
  14. 14.
    Pitts, R. F.: Physiology of the kidneys and body fluids. Chicago: Year Book Medical Publishers 1963.Google Scholar
  15. 15.
    Semprebene, L., Scuncio, G., Benedetti, V. J. Jr., Fiorani, P.: Studio comparativo della renograf is in condizioni basali ed in corso di diuresi provocata. Importanza diagnostica della ipertensione nefrovascolare. Nuntius Radiol. 11, 1197–1215 (1965).Google Scholar
  16. 16.
    Swyngedauw, J.: Néphrogramme de l’hypertendu. Ann. Biol. clin. 23, 1015–1049 (1965).Google Scholar
  17. 17.
    Taplin, G. V., Dore, E. K., Johnson, D. G.: The hippuran I131 renocystogram. V. Internationales Symposium, Bad Gastein 1962. Munchen: Urban & Schwarzenberg 1963.Google Scholar
  18. 18.
    Tauxe, W. N., Hunt, J. C.: Evaluation of renal function by isotope techniques. Med. clin. N. Amer. 50, 937–945 (1966).PubMedGoogle Scholar
  19. 19.
    Tiegerman, T., Pompilian, V., Pavel, D., Grimberg, L., Petrescu, C., Erena, R.: Cercetări asupra dinamicii inbunătătirii functiilor renale după insuficienta renală acută. Medicina Int. (Bucharest) 21, 1449–1462 (1969).Google Scholar
  20. 20.
    Wedeen, R. P., Goldstein, M. H., Levitt, M. F.: The radioisotope renogram in normal subjects. Amer. J. Med. 34, 765–774 (1963).PubMedCrossRefGoogle Scholar
  21. 21.
    Winkel, K. zum: Nierendiagnostik mit Radioisotopen. Stuttgart: Georg Thieme 1964.Google Scholar
  22. 22.
    Winkel, K. zum Hallwachs, O., Steinhausen, M.: Kameraszintigraphie und Isotopennephrographie an der Hundeniere und deren Überprüfung durch die Intravitalmikroskopie. Fortschr. Geb. Röntgenstr. 108, 382–393 (1968).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin · Heidelberg 1971

Authors and Affiliations

  • D. Pavel
    • 1
  1. 1.Nuclear Medicine Laboratory of the Vth Medical ClinicBucharestRoumania

Personalised recommendations