Interaction of Drugs

  • J. Weldon Bellville
Part of the Handbuch der experimentellen Pharmakologie/Handbook of Experimental Pharmacology book series (HEP, volume 30)


Drug interactions are important causes of unexpected pharmacologic effects — toxic or therapeutic. The clinicians’ interest has been focused on drug interaction recently, since in an affluent society a large number of patients entering the hospital are receiving medication. Certainly the average patient in the hospital today receives at least six drugs daily (Smith, J. W. et al., 1966) — some drugs that were not even known to medical practice two decades ago. Furthermore, since the end of World War II, the practice of anesthesia has changed drastically in that instead of relying upon one drug to provide anesthesia, analgesia, amnesia and muscular relaxation, a combination of specific drugs is often employed to provide each of these effects in an attempt to assure ideal surgical conditions with minimal physiologic disturbance. The larger the number of drugs a patient receives, the greater the probability for a drug interaction to occur. This increase is not linear but is almost exponentially related to the number of different drugs given (Smith, J. W. et al., 1966).


Drug Interaction Nitrous Oxide Volatile Anesthetic Anesthetic Effect Liver Microsomal Enzyme 
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© Springer-Verlag/Berlin · Heidelberg 1972

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  • J. Weldon Bellville

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