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Interaction of Drugs

  • J. Weldon Bellville
Part of the Handbuch der experimentellen Pharmakologie/Handbook of Experimental Pharmacology book series (HEP, volume 30)

Abstract

Drug interactions are important causes of unexpected pharmacologic effects — toxic or therapeutic. The clinicians’ interest has been focused on drug interaction recently, since in an affluent society a large number of patients entering the hospital are receiving medication. Certainly the average patient in the hospital today receives at least six drugs daily (Smith, J. W. et al., 1966) — some drugs that were not even known to medical practice two decades ago. Furthermore, since the end of World War II, the practice of anesthesia has changed drastically in that instead of relying upon one drug to provide anesthesia, analgesia, amnesia and muscular relaxation, a combination of specific drugs is often employed to provide each of these effects in an attempt to assure ideal surgical conditions with minimal physiologic disturbance. The larger the number of drugs a patient receives, the greater the probability for a drug interaction to occur. This increase is not linear but is almost exponentially related to the number of different drugs given (Smith, J. W. et al., 1966).

Keywords

Drug Interaction Nitrous Oxide Volatile Anesthetic Anesthetic Effect Liver Microsomal Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adams, W. F., Thornton, T. F., Allen, J. G., Gonzales, D. E.: The danger and prevention of citrate intoxication in massive transfusion of whole blood. Ann. Surg. 120, 656–669 (1944).PubMedGoogle Scholar
  2. Adriani, J.: The chemistry and physics of anesthetic, 2nd ed. Springfield, Ill.: Charles C. Thomas 1962.Google Scholar
  3. Ariens, E. J.: Affinity and intrinsic activity in the theory of competitive inhibition. Part I. Problems and theory. Arch. intern. pharmacodynamic 99, 32–50 (1954).Google Scholar
  4. Ariens, E. J., van Rossum, J. M., Simonis, A. M.: Affinity, intrinsic activity and drug interactions. Pharmacol. Revs 9, 218–236 (1957).Google Scholar
  5. Asatoor, A. M., Levi, A. J., Milne, M. D.: Tranylcypromine and cheese. Lancet 1963 II, 733–734.CrossRefGoogle Scholar
  6. Baekeland, F., Greene, N. M.: Effect of diethyl ether on tissue distribution and metabolism of pentobarbital in rats. Anesthesiology 19, 724–732 (1958).PubMedCrossRefGoogle Scholar
  7. Baraka, A.: The influence of carbon dioxide on the neuromuscular block of tubocurarine chloride in the human subject. Brit. J. Anaesthesia 36, 272–278 (1964).CrossRefGoogle Scholar
  8. Baraka, A.: (2) Effect of halothane on tubocurarine and suxamethionium block in man. Brit. J. Anaesthesia 40, 602–606 (1968).CrossRefGoogle Scholar
  9. Baraka, A., Gabali, F.: (1) Correlation between tubocurarine requirements and plasma protein pattern. Brit. J. Anaesthesia 40, 89–93 (1968).CrossRefGoogle Scholar
  10. Bellville, J. W., Fleischli, G.: The interaction of morphine and nalorphine on respiration. Clin. Pharmacol. Therap. 9, 152–161 (1968).Google Scholar
  11. Bellville, J. W., Murphy, T., Howland, W. S.: Potency of thiopental plus β, β-ethylmethylglutarimide. J. Pharmacol. Exptl Therap. 130, 364–366 (1960).Google Scholar
  12. Bellville, J. W., Seed, J. C.: A respiratory carbon dioxide response curve computer. Science 130, 1079 to 1083 (1959).PubMedCrossRefGoogle Scholar
  13. Bentley, G. A., Savidge, S.: The simultaneous administration of thiopental plus bemegride or other derivatives of glutaric acid to dogs. Brit. J. Anaesthesia 30, 506–514 (1968).CrossRefGoogle Scholar
  14. Bunker, J. P., Stetson, J. B., Coe, R. C., Grillo, H. C., Murphy, A. J.: Citric acid intoxication. J. Am. Med. Assoc. 157, 1361–1367 (1955).PubMedGoogle Scholar
  15. Cascorbi, H. F., Loecher, C. K.: Antagonism and synergism of six volatile anesthetic agents and flurothyl, a convulsant ether. Anesthesia & Analgesia 46, 546–550 (1967).Google Scholar
  16. Clark, A. J.: The antagonism of acetylcholine by atropine. J. Physiol. (London) 61, 547–556 (1926).Google Scholar
  17. Clayton, J. W.: The toxicity of flurocarbons with special reference to chemical constitution. J. Occup. Med. 4, 262–273 (1962).Google Scholar
  18. Clintton-Brock, J.: Two cases of poisoning by contamination of nitrous oxide with higher oxides of nitrogen during anaesthesia. Brit. J. Anaesthesia 39, 388–392 (1967).CrossRefGoogle Scholar
  19. Cohen, E. N.: Fluorescent analysis of d-tubocurarine hydrochloride. J. Lab. Clin. Med. 61, 338–345 (1963).PubMedGoogle Scholar
  20. Cohen, E. N., Brewer, H. W., Bellville, J. W., Sher, R.: The chemistry and toxicology of dichlorohexafluorobutene. Anesthesiology 26, 140–153 (1965).PubMedCrossRefGoogle Scholar
  21. Cohen, E. N., Hood, N.: Application of low-temperature autoradiography to studies of the uptake and metabolism of volatile anesthetics in the mouse: II. Diethyl Ether. Anesthesiology 31, 61–68 (1969).PubMedCrossRefGoogle Scholar
  22. Cohen, E. N., Paulson, W. J., Bernice, E.: Studies of d-tubocurarine with measurements of concentration in human blood. Anesthesiology 18, 300–309 (1957).PubMedCrossRefGoogle Scholar
  23. Conney, A. H., Davison, C., Gastel, R., Burns, J. J.: Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs. J. Pharmacol. Exptl Therap. 180, 1–8 (1960).Google Scholar
  24. Eger II, E. I., Saidman, L. J., Brandstater, B.: Temperature dependence of halothane and cyclopropane anesthesia in dogs: Correlation with some theories of anesthetic action. Anesthesiology 26, 764–770 (1965).PubMedCrossRefGoogle Scholar
  25. Finney, D. J.: Statistical method in biological assay. London: Charles Griffin Company, Ltd. 1964.Google Scholar
  26. Forrest, W. H., Jr., Bellville, J. W.: Respiratory effects of alphaprodine in man. Obstet. Gynecol. 81, 61–68 (1968).CrossRefGoogle Scholar
  27. Gaddum, J. H.: The action of adrenaline and ergotamine on the uterus of the rabbit. J. Physiol. (London) 61, 141–150 (1926).Google Scholar
  28. Gaddum, J. H.: Theories of drug antagonism. Pharmacol. Revs 9, 211–218 (1957).Google Scholar
  29. Gissen, A. J., Karis, J. H., Nastuk, W. L.: Effect of halothane on neuromuscular transmission. J. Am. Med. Assoc. 197, 770–774 (1966).CrossRefGoogle Scholar
  30. Goldstein, A.: The interaction of drugs and plasma proteins. Pharmacol. Revs 1, 102–165 (1949).Google Scholar
  31. Green, N. M., Whittaker, D. J.: Duration of action of pentobarbital as influenced by ether anesthesia in rats. Anesthesiology 18, 165 (1957).CrossRefGoogle Scholar
  32. Gunther, R. E., Bauman, J.: Obstetrical caudal anesthesia I: a randomized study comparing 1% mepivacaine with 1% lidocaine plus epinephrine. Anesthesiology 31, 5–19 (1969).PubMedCrossRefGoogle Scholar
  33. Howland, W. S., Bellville, J. W., Zucker, M. B., Boyan, C. P., Clifton, E. E.: Massive blood replacement V. Failure to observe citrate intoxication. Surg. Gynecol. Obstet. 105, 529–540 (1957).PubMedGoogle Scholar
  34. Kallos, T., Smith, T. C.: Naloxone reversal of pentazocine-induced respiratory depression. J. Am. Med. Assoc. 204, 932 (1968).CrossRefGoogle Scholar
  35. Katz, R. L., Gissen, A. J.: Neuromuscular and electromyographic effects of halothane and its interaction with d-tubocurarine in man. Anesthesiology 28, 564–567 (1967).PubMedGoogle Scholar
  36. Krantz, J. C., Loecher, C. K.: Anesthesia LXX: effect of inert fluorinated agents on fluoro- xene and flurothyl. Anesthesia & Analgesia 46, 271–274 (1967).CrossRefGoogle Scholar
  37. Lasagna, L.: Drug interaction in the field of analgesic drugs. Proc. Roy. Soc. Med. 58, 978 to 983 (1965).PubMedGoogle Scholar
  38. Loewe, S.: Die quantitativen Probleme der Pharmakologie. Ergeb. Physiol. 27, 47–187 (1928).Google Scholar
  39. Loewe, S.: Isobols of dose-effect relations in the combination of pentamethylenetetrazole and phénobarbital. J. Pharmacol. Exptl Therap. 115, 6–15 (1955).Google Scholar
  40. Loewe, S.: Antagonisms and antagonists. Pharmacol. Revs 9, 237–242 (1957).Google Scholar
  41. Miller, S.: A theory of gaseous anesthetics. Proc. Natl. Acad. Sci. US 47, 1515–1524 (1961).CrossRefGoogle Scholar
  42. Odell, G. B.: Studies in kernicterus I. The protein binding of bilirubin. J. Clin. Invest. 38, 823–833 (1959).PubMedCrossRefGoogle Scholar
  43. Pauling, L.: A molecular theory of general anethesia. Science 134, 15–24 (1961).PubMedCrossRefGoogle Scholar
  44. Price, H. L., Price, M. L.: Relative ganglion blocking potencies of cyclopropane, halothane and nitrous oxide, and the interaction of nitrous oxide with halothane. Anesthesiology 28, 349–353 (1967).PubMedCrossRefGoogle Scholar
  45. Richards, R. K., Kueter, K.: Studies on procaine toxicity: Effects of calcium levulinate and of sodium bisulfite. Anesthesia & Analgesia 22, 283–289 (1943).CrossRefGoogle Scholar
  46. Sabawala, P. B., Dillon, J. P.: Action of volatile anesthetics on human muscle preparation. Anesthesiology 19, 587–594 (1958).PubMedCrossRefGoogle Scholar
  47. Saidman, L. J., Eger II, E. I.: Effect of nitrous oxide and of narcotic premedication on the alveolar concentration of halothane required for anesthesia. Anesthesiology 25, 302–306 (1964).PubMedCrossRefGoogle Scholar
  48. Schild, H. O.: pA, a new scale for the measurement of drug antagonism. Brit. J. Pharmacol. 2, 189–206 (1947).PubMedGoogle Scholar
  49. Schild, H. O.: Drug antagonism and pAx. Pharmacol. Revs. 9, 242–246 (1957).Google Scholar
  50. Sjöqvist, F.: Psychotropic drugs, interaction between monoamine oxidase (MAO) inhibitors and other substances. Proc. Roy. Soc. Med. 58, 967–978 (1965).PubMedGoogle Scholar
  51. Smith, J. W., Seidl, L. G., Cluff, L. E.: Studies on the epidemiology of adverse drug reaction. Ann. Internal Med. 65, 629–640 (1966).Google Scholar
  52. Smith, N. T.: Use of isobolograms in anesthesia. Anesthesia & Analgesia 45, 467–473 (1966).Google Scholar
  53. Smith, N. T., Bellville, J. W., Cohen, E. N.: Interaction of halothane and d-tubocurarine on skeletal muscle in the cat. Pharmacologist 5, 276 (1963).Google Scholar
  54. Smith, N. T., Eger II, E. I., Stoelting, R. K., Whitcher, C. E., Wayne, T. F.: The circulatory effects of the addition of nitrous oxide to halothane anesthesia in man. Anesthesiology 29, 212 to 213 (1968).CrossRefGoogle Scholar
  55. Steinberg, S. S., Bellville, J. W., Seed, J. C.: The effect of atropine and morphine on respiration. J. Pharmacol. Exptl Therap. 121, 71–77 (1957).Google Scholar

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© Springer-Verlag/Berlin · Heidelberg 1972

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  • J. Weldon Bellville

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