Extracorporeal and Peritoneal Dialysis of Drugs

  • George E. Schreiner
  • John F. Maher
  • William P. ArgyJr.
  • Larry Siegel
Part of the Handbuch der experimentellen Pharmakologie/Handbook of Experimental Pharmacology book series (HEP, volume 28 / 1)


The dialysis of drugs and environmental poisons is not a route of elimination which comes quickly to the mind of the pharmacologist who is used to dealing with problems of absorption, metabolism, distribution, and excretion. Yet, in the past few years, dialysis has not only given us substantial insights into some of the problems of drug transport and distribution, but it has also proved to be an effective clinical treatment for the overdose of commonly employed medicinal agents and for rapid removal of some environmental poisons. Nephrologists were able to familiarize themselves with the kinetics of acute and chronic drug over-dosage because the uremic syndrome, itself, partakes of many of the features of an intoxication or poisoning.


Peritoneal Dialysis Blood Flow Rate Environmental Poison Dialysate Flow Synthetic Membrane 
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  1. Abel, J.I., Rountree, L.G., Turner, B.B.: On removal of diffusible substances from circulating blood of living animals by dialysis. J. Pharmacol, exp. Ther. 5, 275–316 (1913).Google Scholar
  2. Ackerman, G.L., Doherty, J.E., Flanigan, W.J.: Peritoneal dialysis and hemodialysis of tritiated digoxin. Ann. intern. Med. 67, 718–723 (1967).PubMedGoogle Scholar
  3. Barenburg, R.L., Kiley, J.E.: Effect of ultrafiltration on artificial kidney kinetics. Trans. Amer. Soc. artif. intern. Org. 7, 9–13 (1961).Google Scholar
  4. Boen, S.T.: Peritoneal dialysis in clinical medicine. 1st ed. Springfield, Illinois: Charles C. Thomas Co. 1964.Google Scholar
  5. Danzig, L.E., Kringel, A. J.: Use of the artificial kidney in treatment of thiocyanate psychosis. J. Amer. med. Ass. 158, 560–563 (1955).Google Scholar
  6. Doolan, P.D., Walsh, W.P., Kyle, L.H., Wishinsky, H.: Acetylsalicylic acid intoxication. A proposed method of treatment. J. Amer. med. Ass. 146, 105–106 (1951).Google Scholar
  7. Edwards, K.D.G., Whyte, H.M.: Streptomycin poisoning in renal failure. An indication for treatment with an artificial kidney. Brit. med. J. 1, 752–754 (1959).PubMedCrossRefGoogle Scholar
  8. Freeman, R.B., Mäher, J.F., Schreiner, G.E.: Hemodialysis for chronic renal failure. Technical considerations. Ann. intern. Med. 62, 519–534 (1965).PubMedGoogle Scholar
  9. Galletti, P.M.: Theoretical considerations about artificial kidneys. Proc. lll Int. Cong. Nephrol. 3, 237–253 (1967).Google Scholar
  10. Gary, N.E., Dotzler, P., Mäher, J.F., Schreiner, G.E.: Determination of glutethimide in serum: An evaluation of thin layer chromatography method compared to spectrophotometric analysis. Clin. Toxic. 1, 273–279 (1968).CrossRefGoogle Scholar
  11. Gary, N.E., Mäher, J.F., Demyttenaere, M.H., Liggero, S.H., Scott, K.G., Matusiak, W., Schreiner, G.E.: Acute propoxyphene hydrochloride intoxication. Arch, intern. Med. 121, 453–457 (1968).CrossRefGoogle Scholar
  12. Hare, H.G., Valtin, H., Gosselin, R.E.: Effect of drugs on peritoneal dialysis in the dog. J. Pharmacol, exp. Ther. 145, 122–129 (1964).Google Scholar
  13. Henderson, L.W.: Peritoneal ultrafiltration dialysis: Enhanced urea transfer using hypertonic peritoneal dialysis fluid. J. clin. Invest. 45, 950–955 (1966).PubMedCrossRefGoogle Scholar
  14. Henderson, L.W., Nolph, K. D.: Altered permeability of the peritoneal membrane after using hypertonic peritoneal dialysis fluid. J. clin. Invest. 48, 992–1001 (1969).PubMedCrossRefGoogle Scholar
  15. James, J. A., Kimbell, L., Read, W.T.: Experimental salicylate intoxication. I. Comparison of exchange transfusion, intermittent peritoneal lavage and hemodialysis as means of removing salicylate. Pediatrics 29, 442–447 (1962).PubMedGoogle Scholar
  16. Karnovsky, M.J.: The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. J. Cell Biol. 35, 213–236 (1967).PubMedCrossRefGoogle Scholar
  17. Kunin, C. M.: A guide to use of antibiotics in patients with renal disease. A table of recommended doses and factors governing serum levels. Ann. intern. Med. 67, 151–158 (1967).PubMedGoogle Scholar
  18. Kyle, L.H., Jeghers, H., Walsh, W.P., Doolan, P.D., Wishinsky, H., Pallotta, A.: The application of hemodialysis to the treatment of barbiturate poisoning. J. clin. Invest. 32, 364–371 (1953).PubMedCrossRefGoogle Scholar
  19. Leaf, A., Hays, R.M.: Permeability of the isolated toad bladder and its modification by vasopressin. J. gen. Physiol. 45, 921–932 (1962).PubMedCrossRefGoogle Scholar
  20. Leonard, E.F., Bluemle, L.W., Jr.: Factors affecting permeability in extracorporeal dialysis. Trans. Amer. Soc. artif. intern. Org. 4, 4–15 (1958).Google Scholar
  21. Leonard, E.F.: Engineering in medicine: Design of an artificial kidney. Trans. N.Y. Acad. Sci. 21, 585–598 (1959).Google Scholar
  22. Leonard, E.F.: The permeability concept as applied to dialysis. Trans. Amer. Soc. artif. intern. Org. 6, 33–37 (1960).Google Scholar
  23. Lyman, D.J.: New synthetic membranes for the dialysis of blood. Trans. Amer. Soc. artif. intern. Org. 10, 17–20 (1964).Google Scholar
  24. Lyman, D.J., Loo, B.H., Crawford, R.W.: New synthetic membranes for dialysis. I. A copolyetherester membrane system. Biochem. J. 3, 985–990 (1964).CrossRefGoogle Scholar
  25. Lyman, D.J., Muir, W.M.: New synthetic membrane for the dialysis of blood. III. The concept of 419 liquid partition of biological molecules by membranes. Trans. Amer. Soc. artif. intern. Org. 11, 91–94 (1965).Google Scholar
  26. Maddock, U.K., Jr., Bloomer, H.A.: Meprobamate overdosage. Evaluation of its severity and methods of treatment. J. Amer. med. Ass. 201, 999–1003 (1967).CrossRefGoogle Scholar
  27. Mäher, J.F.: Discussion. Trans. Amer. Soc. artif. intern. Org. 7, 20 (1961).Google Scholar
  28. Mäher, J.F., Freeman, R.B., Schmitt, G., Schreiner, G.E.: Adherance of metals to cellophane membranes and removal by whole blood: A mechanism of solute transport during dialysis. Trans. Amer. Soc. artif. intern. Org. 11, 104–109 (1965).Google Scholar
  29. Mäher, J.F., Freeman, R.B., Setter, J.G., Rubin, M., Schreiner, G.E.: Dialysance studies of various solutes and biochemical changes during hemodialysis. Trans. Amer. Soc. artif. intern. Org. 10, 332–336 (1964).Google Scholar
  30. Mäher, J.F., Schreiner, G. E.: The dialysis of poisons and drugs. Trans. Amer. Soc. artif. intern. Org. 13, 369–393 (1967).Google Scholar
  31. Mäher, J.F., Schreiner, G. E.: The dialysis of poisons and drugs. Trans. Amer. Soc. artif. intern. Org. 14, 440–453 (1968).Google Scholar
  32. Mäher, J.F., Schreiner, G. E.: Current status of dialysis of poisons and drugs. Trans. Amer. Soc. artif. intern. Org. 15, 461–477 (1969).Google Scholar
  33. Mäher, J.F., Schreiner, G. E., Marc-Aurele, J.: Methodologie problems associated with in vitro measurements of dialysance. Trans. Amer. Soc. artif. intern. Org. 5, 120–124 (1959).Google Scholar
  34. Mäher, J.F., Schreiner, G. E., Westervelt, F.B., Jr.: Acute glutethimide intoxication. I. Clinical experience (22 patients) compared to acute barbiturate intoxication (63 patients). Amer. J. Med. 33, 70–82 (1962).PubMedCrossRefGoogle Scholar
  35. Marc-Aurele, J., Schreiner, G.E.: The dialysance of ethanol and methanol: A proposed method for the treatment of massive intoxication by ethyl or methyl alcohol. J. clin. Invest. 39, 802–807 (1960).PubMedCrossRefGoogle Scholar
  36. Merrill, J.P., Weller, J.M.: Treatment of bromism with the artificial kidney. Ann. intern. Med. 37, 186–190 (1952).PubMedGoogle Scholar
  37. Nolph, K.D., Hano, J.E., Teschan, P.E.: Peritoneal sodium transport during hypertonic peritoneal dialysis. Physiologic mechanisms and clinical implications. Ann. intern. Med. 70, 931–942 (1969).PubMedGoogle Scholar
  38. Pappenheimer, J. R.: Passage of molecules through capillary walls. Physiol. Rev. 33, 387–423 (1953).PubMedGoogle Scholar
  39. Renkin, E.M.: The relation between dialysance, membrane area, permeability and blood flow in the artificial kidney. Trans. Amer. Soc. artif. intern. Org. 2, 102–105 (1956).Google Scholar
  40. Renkin, E.M., Pappenheimer, J.R.: Wasserdurchlässigkeit und permeabilität der kapillarwände. Ergebn. Physiol. 49, 59–126 (1957).PubMedGoogle Scholar
  41. Schmitt, G.W., Mäher, J.F., Schreiner, G.E.: Ethacrynic acid enhanced bromuresis. A comparison with peritoneal and hemodialysis. J. Lab. clin. Med. 68, 913–922 (1966).PubMedGoogle Scholar
  42. Schreiner, G. E.: The role of hemodialysis (artificial kidney) in acute poisoning. Arch, intern. Med. 102, 896–913 (1958a).Google Scholar
  43. Schreiner, G. E., Berman, L.B., Kovach, R., Bloomer, H.A.: Acute glutethimide (Doriden) poisoning: The use of bemegride (Megimide) and hemodialysis. Arch, intern. Med. 101, 899–911 (1958b).Google Scholar
  44. Schreiner, G. E., Mäher, J.F., Marc-Aurele, J., Knowlan, D., Alvo, M.: Ethylene glycol — two indications for hemodialysis. Trans. Amer. Soc. artif. intern. Org. 5, 81–86 (1959).Google Scholar
  45. Setter, J.G., Freeman, R.B., Mäher, J.F., Schreiner, G.E.: Factors influencing the dialysis of barbiturates. Trans. Amer. Soc. artif. intern. Org. 10, 340–344 (1964).Google Scholar
  46. Westervelt, F.B., JR.: Ethchlorvynol (Placidyl) intoxication. Experience with five patients including treatment with hemodialysis. Ann. intern. Med. 64, 1229–1236 (1966).PubMedGoogle Scholar
  47. Wieth, J.O.: Hemodialysis in barbiturate poisoning. Int. Anesth. Clin. 4, 359–371 (1966).CrossRefGoogle Scholar
  48. Wilcox, C., Freeman, R.B., Mäher, J.F., Schreiner, G.E.: Comparison of physical properties and permeability of six cellulose membranes. Trans. Amer. Soc. artif. intern. Org. 12, 44–52 (1966).Google Scholar
  49. Wolf, A.V., Remp, D.G., Kiley, J.E., Currie, G.D.: Artificial kidney function: Kinetics of hemodialysis. J. clin. Invest. 30, 1062–1070 (1951).PubMedCrossRefGoogle Scholar
  50. Yudis, M., Swartz, C., Onesti, G., Ramirez, O., Snyder, D., Brest, A.: Hemodialysis for methypyrlon (Nodular) poisoning. Ann. intern. Med. 68, 1301–1304 (1968).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1971

Authors and Affiliations

  • George E. Schreiner
  • John F. Maher
  • William P. ArgyJr.
  • Larry Siegel

There are no affiliations available

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