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The Role of the Uterus in the Regulation of Ovarian Periodicity

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Mammalian Reproduction

Abstract

In order to adequately assess the possible role of the uterus in the regulation of ovarian periodicity it is necessary to consider in some detail the overall concept of ovarian cyclicity. Following the development and wide use in recent years of highly sensitive and reliable radioimmunoassay methods for the estimation of pituitary and gonadal hormones, considerable research effort has been expended which has increased our basic understanding of the mechanisms which are involved in the control of ovarian periodicity. Principally these advances have come in the area of the possible means by which the pituitary exerts a regulatory action on the growth and maturation of the follicle, its ovulation, and the subsequent morphological and functional development of the corpus luteum. Although much additional information remains to be gathered before a definitive statement can be made on the precise sequence of endocrinological events which characterize normal ovarian periodicity, there has emerged a scheme which will be presented as a working model from which this paper will attempt to postulate the role of the uterus in the control of corpus luteum function. Fig. 1 is a graphic illustration of the interrelationships between the hypothalamus, pituitary and ovary and includes the possible regulatory influence of the uterus and embryo.

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  1. Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, USA

    Burton V. Caldwell

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  1. Burton V. Caldwell
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  1. Pharmaforschung Schering AG, Müllerstraße 170–172, D-1000, Berlin 65, Germany

    Heinz Gibian

  2. Universitätsfrauenklinik, D-5300, Bonn-Venusberg, Germany

    Ernst Jürgen Plotz

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Caldwell, B.V. (1970). The Role of the Uterus in the Regulation of Ovarian Periodicity. In: Gibian, H., Plotz, E.J. (eds) Mammalian Reproduction. Colloquium der Gesellschaft für Biologische Chemie in 9.–11. April 1970 in Mosbach/Baden, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-64993-6_19

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