Excitatory Transmitter Substances

  • John Carew Eccles


As pointed out by Paton (1958), Curtis (1961b) and McLennan (1963), several criteria have to be satisfied before one can have full confidence in classifying a substance as a synaptic transmitter: the substance must exist in sufficient quantities in the presynaptic terminals, which must also contain a synthesizing enzyme system; stimulation of the presynaptic nerves must release the substance in adequate quantities from the presynaptic terminals; the action of the substance on the postsynaptic cell must be identical with that of the synaptic action, particularly when applied by micro-electrophoretic techniques; there should be an inactivating enzyme system in the region of the synaptic cleft; when the action of drugs is tested by micro-electrophoretic injection, the pharmacology of the synaptic transmission and of the postsynaptic action of the substance must be similar.


Receptor Site Superior Cervical Ganglion Acidic Amino Acid Neuromuscular Synapse Cholinergic Synapse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag OHG, Berlin Göttingen Heidelberg 1964

Authors and Affiliations

  • John Carew Eccles
    • 1
  1. 1.The Australian National UniversityCanberraAustralia

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